700-16-3 = 2875-18-5 + 3512-16-1 + 76469-41-5 + 82878-63-5 + 67815-54-7 反应条件:1.1 Reagents: Triethylsilane Catalysts: (Oc-6-43)-[1,3-Bis[2,6-Bis(1-Methylethyl)Phenyl]-1,3-Dihydro-2H-Imidazol-2-Ylide... Solvents: Tetrahydrofuran; 19.45 H,343 K 标题:Catalytic Hydrodefluorination Of Aromatic Fluorocarbons By Ruthenium N-Heterocyclic Carbene Complexes 作者:Reade,Steven P.; Et Al 参考文献:Journal Of The American Chemical Society 日期:2009 卷标:131(5) 页码:1847-1861
专利号:US-2012215002-A1 优先权日:2009-10-09 标 题:Synthesis of optically active intermediate for the preparation of montelukast 发明人:LEFORT LAURENT 权利人:LEFORT LAURENT 摘要:The present invention relates to the synthesis of optically active alcohols by means of enantioselective hydrogenation of ketones in biphasic systems. In particular the present invention relates to the synthesis of an optically active alcohol of general formula (1).
专利号:US-2007260076-A1 优先权日:2003-12-05 标 题:Practical, Cost-Effective Synthesis of Ubiquinones 发明人:LIPSHUTZ BRUCE H; BERL VOLKER; SHEIN KARIN; WETTERICH FRANK 权利人:LIPSHUTZ BRUCE H; BERL VOLKER; SHEIN KARIN; WETTERICH FRANK 摘要:The present invention provides a convergent method for the synthesis of ubiquinones and ubiquinone analogues. Also provided are precursors of ubiquinones and their analogues that are useful in the methods of the invention. The invention further provides an improved method for the carboalumination of alkyne substrates.
专利号:US-2006167289-A1 优先权日:2003-12-05 标题 :Practical, cost-effective synthesis of ubiquinones 发明人:LIPSHUTZ BRUCE H; BERL VOLKER; SCHEIN KARIN; WETTERICH FRANK 权利人:ZYMES LLC 摘要:The present invention provides a convergent method for the synthesis of ubiquinones and ubiquinone analogues. Also provided are precursors of ubiquinones and their analogues that are useful in the methods of the invention. The invention further provides an improved method for the carboalumination of alkyne substrates.
专利号:US-6852895-B2 优先权日:2000-08-15 标题:Practical, cost-effective synthesis of CoQ10 发明人:LIPSHUTZ BRUCE H; MOLLARD PAUL 权利人:ZYMES INC 摘要:The present invention provides a convergent method for the synthesis of ubiquinones and ubiquinone analogues. Also provided are precursors of ubiquinones and their analogues that are useful in the methods of the invention.
专利号:US-7521478-B2 优先权日:2002-07-30 标 题 :Total synthesis of myriaporones 发明人:DEL POZO LOSADA CARLOS; FRANCESCH ANDRES; MARCHANTE CARMEN CUEVAS; ALVAREZ MARTA PEREZ 权利人:PHARMA MAR SAU 摘要:Compounds of the general formula (I) or a pharmaceutically acceptable salt, derivative, prodrug or stereoisomer thereof are provided: wherein the substituent groups defined by R are each independently selected from the group consisting of H, SiR′ 3 , SOR′, SO 2 X, C(â•?O)R′, C(â•?O)OR′, C(â•?O)NR′, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, aryl, heteroaryl or aralkyl; the group R′ is selected from substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, aminoalkyl, aryl, aralkyl and heterocyclic groups; and the group R″ is selected from the group consisting of H, OH, OR′, OCOR′, SH, SR′, SOR′, SO 2 R′, NO 2 , NH 2 , NHR′, N(R′) 2 , NHCOR′, N(COR′) 2 , NHSO 2 R′, CN, halogen, C(â•?O)H, C(â•?O)R′, CO 2 H, CO 2 R′, CH 2 OR, substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkylidene, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and substituted or unsubstituted heteroaromatic; with the proviso that the compound is not compound 1, 3 or 4 of U.S. Pat.No. 5,514,708. The compounds have antitumour activity. A synthetic route is also provided.
专利号:US-8648202-B2 优先权日:2008-07-25 标 题:Bis(perfluoroalkyl)phosphinous acids and derivatives and use thereof 发明人:HOGE BERTHOLD; BADER ANNE JULIA; KURSCHEID BORIS; IGNATYEV NIKOLAI MYKOLA; AUST EMIL FERDINAND 权利人:HOGE BERTHOLD; BADER ANNE JULIA; KURSCHEID BORIS; IGNATYEV NIKOLAI MYKOLA; AUST EMIL FERDINAND; MERCK PATENT GMBH 摘要:The invention relates to bis(perfluoroalkyl)phosphinous acids, bis(perfluoroalkyl)thiophosphinous acids and derivatives, the synthesis thereof and the use thereof, in particular for the synthesis of air-stable metal complexes for catalytic processes.
[参考文献]: Barbara Procacci, Et Al. Photochemical Reactions Of Fluorinated Pyridines At Half-Sandwich Rhodium Complexes: Competing Pathways Of Reaction. Organometallics. 2014 Jan 13;33(1):45-52.
合成参考文献
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