CAS: 1508-76-5; 1-Cyclohexyl-1-Phenyl-3-(Pyrrolidin-1-yl)Propan-1-Ol Hydrochloride

该化合物是一种合成抗胆碱酯酶药物,主要用于治疗帕金森病症状和药物诱发的超杀螨症状;它的作用是阻塞乙酰胆碱受体,这有助于恢复脑中多巴胺和乙酰胆碱之间的平衡,缓解僵化和激素等症状;该化合物通常通过口服方式施用,以其迅速吸收和在身体中分布为名;盐酸丙烯作为白到白的晶状粉,在水中溶解,熔点相对较低;其化学配方反映了其结构,包括管状环,有助于其药性活动;常见副作用可能包括干口,视力模糊,内植和尿液保留,这是抗胆碱剂的典型特征;由于它可能引起镇静剂,因此在使用该药物时,应谨慎行事或驾驶.

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    专利信息


    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

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    主要参考文献


    1: Campbell MJ, Demetriou B, Jones R. Assay of procyclidine hydrochloride, cyclizine hydrochloride and diethylcarbamazine citrate in tablets using ion-responsive electrodes. Analyst. 1980 Jun;105(1251):605-11. Neurology. 1957 Jul;7(7):485-9. German. German.

    合成参考文献


    摘要:British Journal of Pharmacology and Chemotherapy., 10(383), 1955 []
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