专利号:US-8785632-B2 优先权日:2004-08-26 标 题:Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors 发明人:CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE 权利人:CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE; AGOURON PHARMA; PFIZER 摘要:Enantiomerically pure compound of formula 1 n nare provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.
专利号:US-2006178374-A1 优先权日:2004-08-26 标 题 :Aminoheteroaryl compounds as protein kinase inhibitors 发明人:CUI JINGRONG J; FUNK LEE A; JIA LEI; KUNG PEI-PEI; MENG JERRY J; NAMBU MITCHELL D; PAIRISH MASON A; SHEN HONG; TRAN-DUBE MICHELLE 权利人:AGOURON PHARMA 摘要:Aminoheteroaryl compounds are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.
参考文献:10.1007/bf00908751 摘要:Smirnov LD, Lokhov RE, Lezina VP, Zaitsev BE, Dyumaev KM. Orientation in the nitration of 2-substituted 3-pyridinols. Russian Chemical Bulletin. 1969 Jul;18(7):1452–5. doi: 10.1007/bf00908751.