CAS: 119347-14-7; (1S,3S,4Ar,6R,8S,11R,12R,12As)-3-(Cinnamoyloxy)-9,12A,13,13-Tetramethyl-4-Methylene-1,2,3,4,4A,5,6,7,8,11,12,12A-Dodecahydro-6,10-Methanobenzo[10]Annulene-1,8,11,12-Tetrayl Tetraacetate
该化合物是一种结构复杂的分类衍生物,具有明显的生化特性.它的四乙氧功能化可提高溶性和稳定性,使之适合于医药化学和药物开发的研究应用.(2E)-3-苯丙基丙烯酸酯引入了额外的再活性,为有针对性的研究提供了可能的修改.这一复合物对于探索以税制为基础的治疗方法(如抗癌剂)中的结构-活动关系特别感兴趣.其定义明确的立体化学学确保实验结果的一致性,而其合成的多功能又允许进一步的衍生.研究人员将这种化合物的价值值用于治疗毒理药学药学和优化生物活性动物.
- 英文名称(1S,3S,4Ar,6R,8S,11R,12R,12As)-3-(Cinnamoyloxy)-9,12A,13,13-Tetramethyl-4-Methylene-1,2,3,4,4A,5,6,7,8,11,12,12A-Dodecahydro-6,10-Methanobenzo[10]Annulene-1,8,11,12-Tetrayl Tetraacetate
- 中文名称2-去乙酞氧基紫杉素J
- IUPAC名称(1S,3S,4aR,6R,8S,11R,12R,12aS)-3-(cinnamoyloxy)-9,12a,13,13-tetramethyl-4-methylene-1,2,3,4,4a,5,6,7,8,11,12,12a-dodecahydro-6,10-methanobenzo[10]annulene-1,8,11,12-tetrayl tetraacetate
- 其它别名2-Deacetoxytaxinine J; 2Alpha-Deacetoxytaxinine J; 2-Propenoic Acid, 3-Phenyl-, (1S,3S,4Ar,6R,8S,11R,12R,12As)-1,8,11,12-Tetrakis(Acetyloxy)-1,2,3,4,4A,5,6,7,8,11,12,12A-Dodecahydro-9,12A,13,13-Tetramethyl-4-Methylene-6,10-Methanobenzocyclodecen-3-Yl Ester, (2E)-; 2-Desacetyltaxininej; [(1S,3S,8S)-7,9,10,13-Tetraacetyloxy-8,12,15,15-Tetramethyl-4-Methylidene-5-Tricyclo[9.3.1.03,8]Pentadec-11-Enyl] 3-Phenylprop-2-Eno Ate
- CAS编号119347-14-7
- MFCD编号:MFCD32644908
- 分子式:C37H46O10分子量:650.77
- 产品CID: 257180
- 产品分类天然产物 → 萜类
MSDS等安全信息
上下游产品
2-deacetoxy-5-(3'-dimethylamino-3'-phenylpropionoxy)taxinine J 2-deacetoxy-7,9,10-trideacetyltaxinine J 3-phenyl-propionic acid 7,9,10,13-tetraacetoxy-8,12,15,15-tetramethyl-4-methylene-tricyclo[9.3.1.0(3,8)]pentadec-11-en-5-ylester 3,8]pentadec-11-en-9-yl esterAcetic acid (1R,3S,4S,5S,7S,8S,9R,10R,13S)-7,10,13-triacetoxy-4-(benzyloxyimino-methyl)-4-hydroxy-5-methanesulfonyloxy-8,12,15,15-tetramethyl-tricyclo[9.3.1.03,8]pentadec-11-en-9-yl ester合成工艺路线路线简述
📜2'-Deacetoxyaustrospicatine置于间氯过氧苯甲酸体系中,用 四氢呋喃,水 用作溶剂,化学反应 18.0H,反应生成2-去乙酞氧基紫杉素j
参考文献:氮杂环丁烷型紫杉烷的合成
标题:氮杂环丁烷型紫杉烷的合成
摘要:从生物碱2'-脱乙酰氧基奥古斯汀碱(2)开始,合成氧杂环丁烷型紫杉烷1-脱氧-2-脱苯甲酰氧基-4-脱乙酰浆果赤霉素vi的氮杂环丁烷等排体.
Doi:10.1016/0040-4039(96)00495-9
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902300000-甲苯
2902500000-苯乙烯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
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📌 第三方产品分析报告
主要参考文献
参考标题:In Vitro And In Vivo Anticancer Activity Of 2-Deacetoxytaxinine J And Synthesis Of Novel Taxoids And Their In Vitro Anticancer Activity☆作者:K. Papi Reddy,Hemant K. Bid,V. Lakshma Nayak,Preeti Chaudhary,J.P. Chaturvedi,K.R. Arya,Rituraj Konwar,T. Narender |发布日期:2009.10
摘要:Line (Hek-293) Has Been Studied. 2-Dat-J (1) Showed Significant In Vitro Activity Against Breast Cancer Cell Line At A Concentration Of 20 μm And 10 μm In Mcf-7 And Mda-Mb-231 Respectively. Few Novel Taxoids Were Derived (7, 8 And 10-13) From The Naturally Occurring 2-Dat-J (1) And Screened For Their Anticancer Activity. The Structure-Activity Relationship Studies Indicated That The Cinnamoyl Group
合成参考文献
参考DOI号:10.1016/0040-4039(96)00495-9
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