CAS: 107091-89-4; 1-Methyl-4-((3-Methylbenzo[d]Thiazol-2(3H)-Ylidene)Methyl)Quinolin-1-Ium 4-Methylbenzenesulfonate

该化合物是一种广泛用作荧光月亮核酸污渍的丙烯酰胺染色,特别是用于检测DNA和各种应用中的RNA,其主要优点包括:与核酸结合时,高荧光量产量,从而导致强烈信号增强.染色显示出显著的斯托克斯变化,减少了背景干扰,提高了检测敏感性.丁甲醇橙可渗透细胞,适合活细胞成像和流动细胞测量.它的结合性相对独立于基构成,确保不同核酸序列的一致性能.染色也具有光化性,允许长时间的成像过程,而不会显著信号降解.

结构式图片

欧盟法规

ECHA物质C&L通报

合成工艺路线路线简述

    📜在 盐酸金刚烷胺体系中,用 水 用作溶剂,化学反应生成噻唑橙
    参考文献:基于宿主-客体在水中组装的线性超分子聚合物的形成.
    标题:基于宿主-客体在水中组装的线性超分子聚合物的形成.
    摘要:发现水介质中的葫芦[n] Urils(n = 7,8)和噻唑橙(to)染料在不同的化学计量比中会形成客体-内含物.通过在水溶液中的疏水作用和π-π相互作用观测到超分子结构和线性超分子聚合物.
    Doi:10.1039/c1Cc12599K

    专利信息


    专利号:EP-3378556-A1
    优先权日:2017-03-20
    标题 :Method for the preparation of a low unspecific binding-support for affinity chromatography and/or on-line synthesis of oligonucleotides
    发明人:PLATELLA CHIARA; MUSUMECI DOMENICA; AMATO JUSSARA; RANDAZZO ANTONIO; PAGANO BRUNO; MONTESARCHIO DANIELA
    权利人:PLATELLA CHIARA; MUSUMECI DOMENICA; AMATO JUSSARA; RANDAZZO ANTONIO; PAGANO BRUNO; MONTESARCHIO DANIELA
    摘要:A method for preparing functionalized solid supports to be used in the on-line synthesis of support-bound, fully deprotected secondary structure-forming oligonucleotides and/or for low unspecific binding affinity chromatography is disclosed.

    专利号:US-12188022-B2
    优先权日:2022-03-18
    标题:Aptamer for specifically recognizing soluble ST2 protein and application of the same
    发明人:DU JIE; WANG YUAN; LI FENGJUAN; TAN XIN; WANG XUE
    权利人:BEIJING INST OF HEART LUNG AND BLOOD VESSEL DISEASES; BEIJING INST OF HEART LUNG & BLOOD VESSEL DISEASES
    摘要:A nucleic acid aptamer specifically recognizing soluble ST2 protein and its application, belonging to the field of variation or genetic engineering, are described. The technical problem addressed includes how to specifically detect sST2 protein. In order to address this technical problem, nucleic acid aptamers of single-stranded DNA with nucleotide sequences are shown in SEQ ID No. 1-10, respectively. SELEX technology, combined with high-throughput sequencing technology and bioinformatics analysis, reduces the rounds of screening and obtains candidate nucleic acid aptamers, and further analyzes its affinity and specificity to obtain a nucleic acid aptamer that specifically recognizes sST2 protein. The nucleic acid aptamer has the characteristics of high specificity, high stability, convenient synthesis, and easy labeling of functional groups, and the like, and may be used for the detection of sST2 protein and the preparation of biosensors, diagnosis and prognosis of cardiovascular diseases and other products.

    专利号:US-2025009786-A1
    优先权日:2021-09-30
    标 题 :Automated synthesis of polymeric dual drugs
    发明人:MATRAY TRACY; VANBRUNT MICHAEL; MCCUTCHEON JOHN MICHAEL
    权利人:SONY GROUP CORP
    摘要:Compounds useful as biologically active compounds with or without fluorescent or colored dyes are disclosed. In some embodiments, the compounds have the following structure (I): (I) or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, L1, L2, L3, L4, L5, L6, L7, L8, L9, L10, L11, M1, M2, M3, l, m, n, p, and q are as defined herein. Additional compound, methods of preparation, pharmaceutical compositions, and methods of treatment related to compounds of Structure (I) are also provided.

    专利号:WO-2021176428-A1
    优先权日:2020-03-06
    标 题 :Phenanthroline, carbazole and flavylium based cyanines and compositions and methods of making and using the same
    发明人:THIMMAIAH GOVINDARAJU; VENKATA SUSEELA YELISETTY; SATHA PARDHASARADHI
    权利人:JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENT RESEARCH
    摘要:The present disclosure is in the field of pharmaceutical and chemical sciences, including the synthesis of theranostic agents and processes for preparing such agents. In particular, the disclosure relates to important phenanthroline, carbazole and flavylium based cyanine group containing chemical compounds, method of preparing such molecules and compositions thereof, and the use of such molecules and compositions as a probe and diagnostic agent in the diagnosis and treatment of diseases including cancer.

    专利号:US-2021277025-A1
    优先权日:2020-03-09
    标题:Bionanocomposite and method thereof
    发明人:SACHDEV DIVYA; BISHT AKSHAY; PASRICHA RENU; TANEJA NEETU KUMRA; RANA J S
    权利人:NATIONAL INSTITUTE OF FOOD TECH ENTREPRENEURSHIP AND MANAGEMENT NIFTEM
    摘要:A fluorescent bionanocomposite is provided, as well as a composition and method of synthesis of fluorescent bionanocomposite for selective stain for gram negative bacteria.

    专利号:US-2010055676-A1
    优先权日:2004-08-19
    标 题:Method of assaying alpha 1, 4-n-acetylglucosamine transferase (alpha 4gnt) mrna
    发明人:SAITO JUICHI; HAYASHI TOSHINORI
    权利人:TOSOH CORP
    摘要:A method for assaying α1,4-N-acetylgiucosamine transferase (α4GnT) mRNA present in a sample, the method comprising a step of using a first primer homologous to at least a portion downstream from the 5′-end of a specified nucleotide sequence of the RNA and a second primer complementary to at least a portion upstream from the 3′-end of the specified nucleotide sequence to produce double-stranded DNA containing the promoter sequence and the specified nucleotide sequence downstream from the promoter sequence, wherein at least one of the first and second primers has a promoter sequence at the 5′-end, a step of using the double-stranded DNA as template to produce an RNA transcript, a step of using the RNA transcript in turn as template for DNA synthesis to produce the double-stranded DNA, a step of nucleic acid amplification in which the aforementioned steps are repeated under conditions that simultaneously promote each of the steps, and a step of assaying the amount of the RNA transcript.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1021/bc100485f
    摘要:Stadler AL, Delos Santos JO, Stensrud ES, Dembska A, Silva GL, Liu S, Shank NI, Kunttas-Tatli E, Sobers CJ, Gramlich PM, Carell T, Peteanu LA, McCartney BM, Armitage BA. Fluorescent DNA nanotags featuring covalently attached intercalating dyes: synthesis, antibody conjugation, and intracellular imaging. Bioconjug Chem. 2011 Aug 17;22(8):1491–502.
    参考文献:10.1021/bc200184a
    摘要:Kubota T, Ikeda S, Yanagisawa H, Yuki M, Okamoto A. Cy5-conjugated hybridization-sensitive fluorescent oligonucleotides for ratiometric analysis of nuclear poly(A)+ RNA. Bioconjug Chem. 2011 Aug 17;22(8):1625–30. doi: 10.1021/bc200184a.
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