其它别名THIAZOLE ORANGE; 1-METHYL-4-[(3-METHYL-2(3H)-BENZOTHIAZOLYLIDENE)METHYL]QUINOLINIUM P-TOSYLATE; THIAZOLE ORANGE, FOR FLUORESCENCE; Quinolinium, 1-methyl-4-((3-methyl-2(3H)-benzothiazolylidene)methyl)-, salt with 4-methylbenzenesulfonic acid (11)
专利号:EP-3378556-A1 优先权日:2017-03-20 标题 :Method for the preparation of a low unspecific binding-support for affinity chromatography and/or on-line synthesis of oligonucleotides 发明人:PLATELLA CHIARA; MUSUMECI DOMENICA; AMATO JUSSARA; RANDAZZO ANTONIO; PAGANO BRUNO; MONTESARCHIO DANIELA 权利人:PLATELLA CHIARA; MUSUMECI DOMENICA; AMATO JUSSARA; RANDAZZO ANTONIO; PAGANO BRUNO; MONTESARCHIO DANIELA 摘要:A method for preparing functionalized solid supports to be used in the on-line synthesis of support-bound, fully deprotected secondary structure-forming oligonucleotides and/or for low unspecific binding affinity chromatography is disclosed.
专利号:US-12188022-B2 优先权日:2022-03-18 标题:Aptamer for specifically recognizing soluble ST2 protein and application of the same 发明人:DU JIE; WANG YUAN; LI FENGJUAN; TAN XIN; WANG XUE 权利人:BEIJING INST OF HEART LUNG AND BLOOD VESSEL DISEASES; BEIJING INST OF HEART LUNG & BLOOD VESSEL DISEASES 摘要:A nucleic acid aptamer specifically recognizing soluble ST2 protein and its application, belonging to the field of variation or genetic engineering, are described. The technical problem addressed includes how to specifically detect sST2 protein. In order to address this technical problem, nucleic acid aptamers of single-stranded DNA with nucleotide sequences are shown in SEQ ID No. 1-10, respectively. SELEX technology, combined with high-throughput sequencing technology and bioinformatics analysis, reduces the rounds of screening and obtains candidate nucleic acid aptamers, and further analyzes its affinity and specificity to obtain a nucleic acid aptamer that specifically recognizes sST2 protein. The nucleic acid aptamer has the characteristics of high specificity, high stability, convenient synthesis, and easy labeling of functional groups, and the like, and may be used for the detection of sST2 protein and the preparation of biosensors, diagnosis and prognosis of cardiovascular diseases and other products.
专利号:US-2025009786-A1 优先权日:2021-09-30 标 题 :Automated synthesis of polymeric dual drugs 发明人:MATRAY TRACY; VANBRUNT MICHAEL; MCCUTCHEON JOHN MICHAEL 权利人:SONY GROUP CORP 摘要:Compounds useful as biologically active compounds with or without fluorescent or colored dyes are disclosed. In some embodiments, the compounds have the following structure (I): (I) or a stereoisomer, tautomer or salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, L1, L2, L3, L4, L5, L6, L7, L8, L9, L10, L11, M1, M2, M3, l, m, n, p, and q are as defined herein. Additional compound, methods of preparation, pharmaceutical compositions, and methods of treatment related to compounds of Structure (I) are also provided.
专利号:WO-2021176428-A1 优先权日:2020-03-06 标 题 :Phenanthroline, carbazole and flavylium based cyanines and compositions and methods of making and using the same 发明人:THIMMAIAH GOVINDARAJU; VENKATA SUSEELA YELISETTY; SATHA PARDHASARADHI 权利人:JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENT RESEARCH 摘要:The present disclosure is in the field of pharmaceutical and chemical sciences, including the synthesis of theranostic agents and processes for preparing such agents. In particular, the disclosure relates to important phenanthroline, carbazole and flavylium based cyanine group containing chemical compounds, method of preparing such molecules and compositions thereof, and the use of such molecules and compositions as a probe and diagnostic agent in the diagnosis and treatment of diseases including cancer.
专利号:US-2021277025-A1 优先权日:2020-03-09 标题:Bionanocomposite and method thereof 发明人:SACHDEV DIVYA; BISHT AKSHAY; PASRICHA RENU; TANEJA NEETU KUMRA; RANA J S 权利人:NATIONAL INSTITUTE OF FOOD TECH ENTREPRENEURSHIP AND MANAGEMENT NIFTEM 摘要:A fluorescent bionanocomposite is provided, as well as a composition and method of synthesis of fluorescent bionanocomposite for selective stain for gram negative bacteria.
专利号:US-2010055676-A1 优先权日:2004-08-19 标 题:Method of assaying alpha 1, 4-n-acetylglucosamine transferase (alpha 4gnt) mrna 发明人:SAITO JUICHI; HAYASHI TOSHINORI 权利人:TOSOH CORP 摘要:A method for assaying α1,4-N-acetylgiucosamine transferase (α4GnT) mRNA present in a sample, the method comprising a step of using a first primer homologous to at least a portion downstream from the 5′-end of a specified nucleotide sequence of the RNA and a second primer complementary to at least a portion upstream from the 3′-end of the specified nucleotide sequence to produce double-stranded DNA containing the promoter sequence and the specified nucleotide sequence downstream from the promoter sequence, wherein at least one of the first and second primers has a promoter sequence at the 5′-end, a step of using the double-stranded DNA as template to produce an RNA transcript, a step of using the RNA transcript in turn as template for DNA synthesis to produce the double-stranded DNA, a step of nucleic acid amplification in which the aforementioned steps are repeated under conditions that simultaneously promote each of the steps, and a step of assaying the amount of the RNA transcript.