CAS: 934-98-5; 2-(4-Methylpiperazin-1-yl)Ethanamine

相似化合物

1484327-92-5 192130-34-0 90482-07-8

上下游产品

CAS号874-77-1 4-甲基-1-哌嗪乙腈 | CAS号45813-02-3 1-甲基-4-丙-2-炔基-哌嗪 | CAS号109-01-3 N-甲基哌嗪 | CAS号107-09-5 2-溴乙胺

📜2-(2-(N-Methylpiperazin-4-yl)Ethyl)-1H-Isoindole-1,3(2H)-Dione置于一水合肼体系中,用 乙醇 作为反应溶剂,化学反应生成 4-甲基-1-哌嗪乙胺
参考文献:含有2,4-二甲基-1H-吡咯-3-甲酰胺基的5-Bromo-7-氮杂吲哚-2-One衍生物的合成及抗肿瘤活性.
标题:含有2,4-二甲基-1H-吡咯-3-甲酰胺基的5-Bromo-7-氮杂吲哚-2-One衍生物的合成及抗肿瘤活性.
摘要:我们在这里报告了设计和合成的一系列新型的5-溴-7-氮杂吲哚-2-酮衍生物,其中含有2,4-二甲基-1H-吡咯-3-羧酰胺部分.通过mtt分析评估了这些新合成的衍生物对所选癌细胞系的体外活性.结果表明,某些化合物具有广谱抗肿瘤功效,并且发现活性最高的化合物23P(ic50:2.357-3.012μm)比舒尼替尼(ic50:31.594-49.036μm)对hepg2,A549和skov-3的效力更高. .
DOI:10.3390/molecules21121674

专利信息

专利号:US-10772971-B2
优先权日:2017-06-22
标 题:Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates
发明人：GURIJALA VENU REDDY; BOLLU SATYANARAYAN REDDY; LEBLANC JACQUES; LOWINGER TIMOTHY B; MCGILLICUDDY DENNIS; YIN MAO; YURKOVETSKIY ALEKSANDR V
权利人:MERSANA THERAPEUTICS INC; MERSANA THERPEUTICS INC
摘要:The disclosure provides methods of synthesis of polymeric scaffolds, e.g., those useful for conjugating with a protein based recognition-molecule (PBRM) to form PBRM-polymer-drug conjugates, and PBRM-polymer-drug conjugates thereof. The methods according to the disclosure allow for large-scale preparation of polymeric scaffolds having a high purity. In some embodiments, the methods according to the disclosure also allow for the preparation of scaffolds and conjugates thereof in better yield than previously used methods for preparing same. Also disclosed are methods of purifying polymeric scaffolds.

专利号:US-8653223-B2
优先权日:2008-04-16
标题:Transketalized compositions, synthesis, and applications
发明人：SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG
权利人:SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG; SEGETIS INC
摘要:Ketal compounds of the structure I n nand a method of preparation of the compound from polyols and oxocarboxylates, as well as uses thereof.

专利号:US-8003785-B2
优先权日:2008-06-18
标 题 :Halo-substituted pyrimidodiazepines
发明人：CAI JIANPING; CHEN SHAOQING; CHU XIN-JIE; LUK KIN-CHUN; MISCHKE STEVEN GREGORY; SUN HONGMAO; WOVKULICH PETER MICHAEL
权利人:TAKEDA PHARMACEUTICAL
摘要:The present invention provides PLK1 inhibitor compounds of formula I: n nuseful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas. Also provided are intermediate compounds useful in the synthesis of compounds of formula I.

专利号:US-5064962-A
优先权日:1989-02-23
标题:Diaminothiophenes
发明人：WIESENFELDT MATTHIAS; ETZBACH KARL-HEINZ
权利人:BASF AG
摘要:Diaminothiophenes of the formula or tautomers thereof, where R1 and R2 are each hydrogen or together are where T1 is hydrogen, alkyl or phenyl, T2 and T3 are, independently of one another, alkyl or phenyl, or T2 and T3 together with the nitrogen linking them are a heterocyclic radical, R3 is substituted amino and R4 is alkanoyl, benzoyl, cyano, nitro or where T4 is hydrogen, alkyl or phenyl and T5 is the radical of a primary amine or of an active methylene compound, are prepared as described. The present diaminothiophene compound is useful in the synthesis of dyes, crop protection agents and pharmaceuticals.

专利号:US-4617377-A
优先权日:1983-07-13
标 题:Synergistine derivatives and their preparation
发明人：CORBET JEAN-PIERRE; COTREL CLAUDE; FARGE DANIEL; PARIS JEAN-MARC
权利人:RHONE POULENC SANTE
摘要:The invention provides new synergistine derivatives of the formula: (I) in which Y=H or N(CH3)2 and R represents: (a) H or OH, (b) a radical of the formula NR1R2, in which R1 and R2=H, phenyl or pyridyl (optionally substituted by dialkylamino (1 to 4 C), alkyl (1 to 10 C) [optionally substituted by OH, SH, COOH, anilino, or alkylamino or dialkylamino of which at least one of the alkyl parts is substituted by OH, SH, COOH or anilino 9 , alkenyl (3 or 4 C) or alkynyl (3 or 4 C), or alternatively R1 and R2 together form a heterocycle optionally containing another heteroatom such as O, S or N (optionally substituted by alkyl), or (c) a halogen atom, a trimethylsilyloxy or dialkylphosphoryloxy radical or a radical -OSO2R3 or -OCOR4, R3 being alkyl, trifluoromethyl, trichloromethyl or optionally substituted phenyl and R4 being defined in the same way as R3 or being an acylalkyl, alkoxycarbonylalkyl or alkoxy radical, and also their salts and their preparation. These products are useful as intermediates in the synthesis of anti-bacterial synergistine derivatives.

专利号:WO-2023071601-A1
优先权日:2021-10-28
标题:Desloratadine derivative, preparation method therefor and application thereof
发明人：YAO CHEN
权利人:TIANJIN NEWSUN INVEST DEVELOPMENT CO LTD
摘要:Disclosed in the present application is a compound as represented by formula (A), wherein-R is-R' or -Y-(CH 2 ) n -R', Y is O or NH, n is 1, 2, 3, 4, 5 or 6, and -R' is diethylamino, pyrrolidinyl, piperazinyl, N-morpholinyl, bis(2-methoxyethyl)amino or 4-methylpiperazinyl. Also disclosed are a synthesis method for the compound shown, and use of the compound shown in the preparation of drugs for relieving or treating or preventing allergy and related symptoms thereof.