CAS: 932-30-9; 2-(Aminomethyl)Phenol

• 英文名称2-(Aminomethyl)Phenol
• 中文名称2-羟基苄胺
• IUPAC名称2-(aminomethyl)phenol
• 其它别名2-(Aminomethyl)phenol
• CAS编号932-30-9
• MFCD编号:MFCD00870498
• EINECS号:213-249-7
• 分子式:C7H9NO
• 分子量:123.15
• 产品CID: 1970690
• 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

• 相似结构搜索
• 产品信息参考;;;;
• InChIKey: KPRZOPQOBJRYSW-UHFFFAOYSA-N
• InChI=1S/C7H9NO/c8-5-6-3-1-2-4-7(6)9/h1-4,9H,5,8H2…
• 计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数1.0

物理性质

• 熔点127-131°C
• 沸点245°C at 760 mmHg
• 闪点102.0±20.4 °C
• 密度1.1±0.1 g/cm3
• pKa:8.63±0.35(预测)
• PSA:46.25
• LogP:0.8509
• 折射率1.594
• 蒸汽压0.0±0.5 mmHg at 25°C
• 溶解性Chloroform (Slightly), Methanol (Very Slightly, Heated)
• 外观形态米色至棕色固体
• 储存条件在惰性气体(氮气或氩气)下 2–8 °C
• 产品应用该化合物是一种强大的Γ-开甲吗啡(ΓKA)净化剂,与ΓKKA的反应速度大约是ΓKAS-蛋白碱吸附剂的形成速度的980倍,从而保护细胞免受ΓKA粘附剂有害影响.体外研究表明,2-HOPBA保护HEPG2细胞免受H2O2诱发的细胞毒性.2HOABA在与氧化性压力有关的疾病中的有益影响也在体内的多个器官和系统中观测到.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  急性毒性 类别4(吸入)
  急性毒性 类别4(经皮)
  急性毒性 类别4(经口)
• 警示词Warning(警告)
• 危险描述H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H332 |吸入有害.
  H312 |皮肤接触有害.
  H302 |吞咽有害.
• 防范说明P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501
• 危险等级IRRITANT
• UN编号NONH for all modes of transport
• 危险品标志Xi
• 安全声明26-37/39
• 危险类别码36/37/38
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 2-Hydroxybenzylamine 主要起始原料 2-Cyanophenol
• 854893-81-5 = 932-30-9
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethyl Acetate; 18 H,Rt
  标题:Concise Copper-Catalyzed Synthesis Of Tricyclic Biaryl Ether-Linked Aza-Heterocyclic Ring Systems
  作者:Mestichelli,Paola; Scott,Matthew J.; Galloway,Warren R. J. D.; Selwyn,Jamie; Parker,Jeremy S.; Et Al
  参考文献:Organic Letters 日期:2013 卷标:15(21) 页码:5448-5451]
  
  611-20-1 = 932-30-9
  反应条件:1.1 Reagents: Phosphoric Acid,Samarium Iodide (Smi2) Solvents: Tetrahydrofuran
  标题:Reductions With Samarium(Ii) Iodide
  作者:Molander,Gary A.
  参考文献:Organic Reactions (Hoboken 日期:1994 卷标:46]
  
  90-02-8 = 932-30-9
  反应条件:1.1 Reagents: Hydrogen,Ammonia Catalysts: Montmorillonite ((Al1.33-1.67Mg0.33-0.67)(Ca0-1Na0-1)0.33Si4(Oh)2O10.Xh2O),Ruthenium Solvents: Water; 6 H,10 Bar,90 °C
  标题:Comparative Account Of Catalytic Activity Of Ru- And Ni-Based Nanocomposites Towards Reductive Amination Of Biomass Derived Molecules
  作者:Gokhale,Tejas A.; Raut,Amol B.; Bhanage,Bhalchandra M.
  参考文献:Molecular Catalysis 日期:2021 卷标:510]
  
  6850-57-3 = 932-30-9
  反应条件:1.1 Reagents: Hydrogen Bromide Solvents: Water; 3 H,Reflux1.2 Reagents: Sodium Hydroxide Solvents: Water; Neutralized,0 °C
  标题:Synthesis,Sar Studies,And Evaluation Of 1,4-Benzoxazepine Derivatives As Selective 5-Ht1A Receptor Agonists With Neuroprotective Effect: Discovery Of Piclozotan
  作者:Kamei,Katsuhide; Maeda,Noriko; Nomura,Kayoko; Shibata,Makoto; Katsuragi-Ogino,Ryoko; Et Al
  参考文献:Bioorganic & Medicinal Chemistry 日期:2006 卷标:14(6) 页码:1978-1992]
  
  918885-51-5 = 932-30-9
  反应条件:1.1 Reagents: Oxygen Catalysts: Iodine Solvents: Tetrahydrofuran,Water; 50 °C
  标题:Iodine Mediated Deprotection Of N-Tert-Butanesulfinyl Amines: A Functional Group Compatible Method
  作者:Chen,Wen; Ren,Jian; Wang,Minshou; Dang,Lingjing; Shen,Xianfu; Et Al
  参考文献:Chemical Communications (Cambridge 日期:2014 卷标:50(47) 页码:6259-6262]
  
  90-02-8 = 932-30-9
  反应条件:1.1 Reagents: Ammonia Solvents: Methanol; Rt; 1 H,Rt1.2 Reagents: Hydrogen Catalysts: Nickel; 2 Mpa,Rt -> 80 °C; 1.5 - 2 Mpa,80 - 90 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; Rt -> 50 °C; 2 H,50 - 60 °C; 50 °C -> 10 °C1.4 Reagents: Ammonium Hydroxide; < 10 °C; 2 H,10 °C -> 0 °C
  标题:Preparation Of O-Hydroxybenzylamine
  参考文献:China]
  
  90-02-8 = 932-30-9
  反应条件:1.1 Reagents: Hydrogen,Ammonia Catalysts: Cobalt (Graphene-Encapsulated) Solvents: Methanol; 4 H,2 Mpa,90 °C
  标题:Facile Manner In Regulating The Graphene-Shelled Structure Of Cobalt Nanoparticles For The Synthesis Of Amines
  作者:Zhuang,Xiuzheng; Liu,Jianguo; Ma,Longlong
  参考文献:Chemrxiv 日期:2021 卷标:1 页码:1-15]
  
  90-02-8 = 932-30-9
  反应条件:1.1 Reagents: Hydrogen,Ammonia Catalysts: Cobalt,Graphene Solvents: Methanol; 4 H,2 Mpa,90 °C
  标题:A General Synthesis Of Amines Via Cobalt Atoms Individually Anchored By Divacancy Sites On Graphene-Shelled Layers
  作者:Zhuang,Xiuzheng; Liu,Jianguo; Ji,Yangqi; Wu,Xiaojun; Zhang,Xinghua; Et Al
  参考文献:Chem Catalysis 日期:2023 卷标:3(8)]
  
  94-67-7 = 932-30-9
  反应条件:1.1 Reagents: Acetic Acid,Zinc; 0.5 H,Rt
  标题:The Efficient Reduction Of Oximes To Amines With Zn And Acetic Acid Under Ultrasonic Irradiation
  作者:Cao,Yu-Qing; Liu,Rui-Yan; Qu,An-Li; Jin,Yuan-Yuan
  参考文献:Organic Chemistry: An Indian Journal 日期:2009 卷标:5(4) 页码:412-415]
  
  94-67-7 = 932-30-9
  反应条件:1.1 Reagents: (Sp-5-12)-(Pyridine)Bis[tetrahydroborato(1-)-Kh,Kh′]Zinc Solvents: Tetrahydrofuran; 0.5 H,Reflux
  标题:First Report For The Efficient Reduction Of Oximes To Amines With Zinc Borohydride In The Form Of (Pyridine)(Tetrahydroborato)Zinc Complex
  作者:Zeynizadeh,Behzad; Zahmatkesh,Karam
  参考文献:Journal Of The Chinese Chemical Society (Taipei 日期:2005 卷标:52(1) 页码:109-112]
  
  94-67-7 = 932-30-9
  反应条件:1.1 Reagents: Alumina,Zirconium Chloride (Zrcl4)1.2 > 1 Min,Rt1.3 Reagents: Sodium Borohydride; 2 Min,Rt
  标题:A Rapid And Practical Protocol For Solvent-Free Reduction Of Oximes To Amines With Nabh4/zrcl4/al2O3 System
  作者:Zeynizadeh,Behzad; Kouhkan,Mehri
  参考文献:Bulletin Of The Korean Chemical Society 日期:2011 卷标:32(9) 页码:3448-3452]
  
  90-02-8 = 932-30-9
  反应条件:1.1 Reagents: Hydrogen,Ammonia Catalysts: Nickel Boride (Ni2B) (Supported On Ts-1 Mol. Sieve) Solvents: Isopropanol; 0.5 Mpa,Rt -> 120 °C; 2 H,4 Mpa,120 °C
  标题:General Construction Of Amine Via Reduction Of N=x (X = C,O,H) Bonds Mediated By Supported Nickel Boride Nanoclusters
  作者:Ke,Da; Zhou,Shaodong
  参考文献:International Journal Of Molecular Sciences 日期:2022 卷标:23(16)]
  
  90-02-8 = 932-30-9
  反应条件:1.1 Reagents: Hydrogen,Ammonia Catalysts: Ruthenium (Boron Nitride Support),Boron Nitride Solvents: Methanol,Water; 12 H,1.0 Mpa,90 °C
  标题:Self-Regulated Catalysis For The Selective Synthesis Of Primary Amines From Carbonyl Compounds
  作者:Gao,Mingxia; Jia,Xiuquan; Ma,Jiping; Fan,Xiaomeng; Gao,Jin; Et Al
  参考文献:Green Chemistry 日期:2021 卷标:23(18) 页码:7115-7121]
  
  611-20-1 = 932-30-9
  反应条件:1.1 Reagents: Oxalic Acid Catalysts: Iron Oxide (Fe3O4),Palladium,Titania; 1.5 H,Rt
  标题:Preparation Of A Magnetic Mesoporous Fe3O4-Pd@tio2 Photocatalyst For The Efficient Selective Reduction Of Aromatic Cyanides
  作者:Zhao,Ziming; Long,Yu; Luo,Sha; Wu,Wei; Ma,Jiantai
  参考文献:New Journal Of Chemistry 日期:2019 卷标:43(16) 页码:6294-6302]
  
  611-20-1 = 932-30-9
  反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Diethyl Ether,Tetrahydrofuran; 0 °C; 30 Min,Rt; 24 H,40 °C1.2 Reagents: Ammonium Chloride Solvents: Water
  标题:Pyruvate Kinase Activators For Use For Increasing Lifetime Of The Red Blood Cells And Treating Anemia
  参考文献:World Intellectual Property Organization]
  
  611-20-1 = 932-30-9
  反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Diethyl Ether,Tetrahydrofuran; 0 °C; 30 Min,Rt; 24 H,40 °C1.2 Reagents: Ammonium Chloride Solvents: Water
  标题:Preparation Of Oxobenzoxazinearylsulfonamide Derivatives For Use As Pkm2 Activators
  参考文献:World Intellectual Property Organization]
  
  611-20-1 = 932-30-9
  反应条件:1.1 Reagents: Hydrogen,Ammonia Catalysts: Nickel Solvents: Methanol; 1.5 H,90 Bar,100 °C
  标题:Synthesis Of Methyl Carbamates From Primary Aliphatic Amines And Dimethyl Carbonate In Supercritical Co2: Effects Of Pressure And Cosolvents And Chemoselectivity
  作者:Selva,Maurizio; Tundo,Pietro; Perosa,Alvise; Dall'Acqua,Federico
  参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(7) 页码:2771-2777]
  
  94-67-7 = 932-30-9
  反应条件:1.1 Reagents: Hydrogen,Hydrochloric Acid Catalysts: Palladium,Carbon Solvents: Methanol,Water
  标题:The Action Of Thiophenols On (N,N'-Disalicylidene-1-Cyclohexene-1,2-Diaminato)Cobalt(Ii)
  作者:Sakata,Kazunori; Tachifuji,Yukihiro; Hashimoto,Mamoru
  参考文献:Synthesis And Reactivity In Inorganic And Metal-Organic Chemistry 日期:1990 卷标:20(7) 页码:901-8]
  
  6850-57-3 = 932-30-9
  反应条件:1.1 Reagents: Boron Tribromide Solvents: Dichloromethane; -78 °C; 30 Min,Rt; 45 Min,40 °C; 6 H,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 13,-20 °C
  标题:Process For Preparation Of α-Amino Acid Esters
  参考文献:China]
  
  94-67-7 = 932-30-9
  反应条件:1.1 Reagents: Sodium Amalgam Solvents: Ethanol,Water; Neutralized,< 55 °C1.2 Reagents: Hydrochloric Acid; Neutralized,< 55 °C1.3 Reagents: Ammonium Hydroxide Solvents: Diethyl Ether; Rt
  标题:Metal Chelates Of Cerium(Iii),Thorium(Iv),And Dioxouranium(Vi); Complexes With Some Derivatives Of Aryl Schiff Bases
  作者:Moustafa,M. E.
  参考文献:Synthesis And Reactivity In Inorganic And Metal-Organic Chemistry 日期:2003 卷标:33(3) 页码:453-468

海关参考信息

• 2902300000-甲苯
  2907121100-间甲酚
  2908199090-其他酚的卤化衍生物
  2908999090-其他酚的硝化衍生物
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• 详情请参考：📖 海关编码查询和海关进出口税则

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