CAS: 90365-74-5; (3S,4S)-1-Benzyl-3,4-Pyrrolidindiol

上下游产品

CAS号75172-31-5 (3R,4R)-3,4-二羟基... | CAS号87-69-4 酒石酸 | CAS号100-46-9 苄胺 | CAS号57495-46-2 (-)-1 4-二-o-甲苯磺... | CAS号90481-32-6 (3S,4S)-吡咯烷-3,4-二醇 | CAS号276862-76-1 (3S,4S)-吡咯烷-3,4... | CAS号150986-62-2 (3R,4R)-3,4-二羟基... | CAS号288313-99-5 (3S,4s)-3,4-二叠氮... | CAS号99135-95-2 (+)-N-苄基-(3R,4R...

(3S,4S)-(-)-1-苄基-3,4-二羟基吡咯烷-2,5-二酮置于硼烷四氢呋喃络合物体系中,用 四氢呋喃 作为反应溶剂,化学反应 3.0H,以86.59%的收率获得产物(3S,4S)-1-苄基吡咯烷-3,4-二醇
参考文献:Synthesis And α-Glucosidase Inhibition Activity Of Dihydroxy Pyrrolidines
标题:Synthesis And α-Glucosidase Inhibition Activity Of Dihydroxy Pyrrolidines
摘要:A New Series Of Deacetylsarmentamide A And B Derivatives,Amides And Sulfonamides Of 3,4-Dihydroxypyrrolidines As Alpha-Glucosidase Inhibitors Were Designed And Synthesized. The Biological Screening Test Against Alpha-Glucosidase Showed That Some Of These Compounds Have The Positive Inhibitory Activity Against Alpha-Glucosidase. Saturated Aliphatic Amides Were More Potent Than The Olefinic Amides. Among All The Compounds,5O/6O Having Polar-Nh2 Group,10F/11F Having Polar-Oh Group On Phenyl Ring Displayed 3-4-Fold More Potent Than The Standard Drugs. Acarbose,Voglibose And Miglitol Were Used As Standard References. The Promising Compounds 6I,5O,6O,10A,11A,10F And 11F Have Been Identified. Molecular Docking Simulations Were Done For Compounds To Identify Important Binding Modes Responsible For Inhibition Activity Of Alpha-Glucosidase. (C) 2017 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2017.04.078

专利信息

专利号:US-2012289733-A1
优先权日:2011-05-11
标 题 :Novel borate derivatives and their applications
发明人：HEISE GLENN L; MYSLINSKA MALGORZATA
权利人:HEISE GLENN L; MYSLINSKA MALGORZATA; ANDERSON DEV CO
摘要:Borates, compositions comprising chiral (cyclic and acyclic) and achiral (cyclic and acyclic) borates; chiral (cyclic and acyclic) and achiral (cyclic and acyclic) biborates; and methods for their synthesis. Additionally, a significantly improved synthetic protocol for the synthesis of wide range of boronates starting from borates or biborates and Grignard or organolithium reagents that can be used for kilo lab and commercial scale production.

专利号:US-2010022549-A1
优先权日:2008-07-23
标题 :Alpha-helix mimetic with functionalized pyridazine
发明人：REBEK JR JULIUS; MOISAN LIONEL; CARELLA ALEXANDRE; MANN ENRIQUE
权利人:SCRIPPS RESEARCH INST
摘要:The synthesis of new α-helix scaffolds mimicking i, i+3 or i+4, i+7 residues, was accomplished. The common pyridazine heterocycle originates from the easily available dimethyl pyridazine-3,6-dicarboxylate building block. These scaffolds may be thought of as synthetic counterparts of amphiphilic α-helices having a hydrophilic face along one side and a hydrophobic face along the other side of the helix.

专利号:US-6090950-A
优先权日:1996-08-23
标 题 :Chiral hydride complexes
发明人：HEISE GLENN L
权利人:ZEELAND CHEMICALS INC
摘要:Novel chiral boron and aluminum hydride complexes, compositions comprising the chiral hydride complexes, and methods for their synthesis and use are described. The novel chiral hydride complexes are of the formulas: MBH4-n-a(R*)n(R')a; MBH2-b(R**) (R')b; MBH(R***); MBH(R*) (R''); MAlH4-n-a(R*)n(R')a; MAlH2-b(R**)(R')b; MAlH(R***); and MAlH(R*) (R''), wherein M is Na+, Li+ or K+; each R* is independently a monodentate chiral ligand; R** is a bidentate chiral ligand; R*** is a tridentate chiral ligand; R' is a monodentate achiral ligand; R'' is a bidentate achiral ligand; n is 1-3; a is 0-2; and b is 0-1, with the proviso that n+a