CAS: 79669-49-1; 5-Bromo-2-Methylbenzoic Acid

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CAS号118-90-1 邻甲基苯甲酸 | CAS号7697-26-9 3-溴-4-甲基苯甲酸 | CAS号7439-89-6 铁粉 | CAS号156001-51-3 5-溴-2-甲基苯腈 | CAS号87-41-2 苯酞 | CAS号939-83-3 2-甲基-5-硝基苯腈 | CAS号50670-64-9 5-氨基-2-甲基苯甲腈 | CAS号7732-18-5 水 | CAS号7726-95-6 溴素 | CAS号60-29-7 乙醚 | CAS号21900-41-4 5-溴-2-甲氧基苄氯 | CAS号19725-82-7 5-溴-2-(羧基甲基)苯甲酸 | CAS号108-39-4 间甲酚 | CAS号79669-50-4 2-甲基-5-溴苯甲酸甲酯 | CAS号99548-54-6 2-甲基-3-溴苯甲酸甲酯 | CAS号258886-04-3 5-溴-2-甲基苄醇 | CAS号79670-17-0 5-溴-2-溴甲基苯甲酸甲酯 | CAS号578-22-3 5-羟基-2-甲基苯甲酸 | CAS号675109-26-9 6-溴异吲哚啉-1-酮 | CAS号567-61-3 2-羟基-6-甲基苯甲酸

对甲苯甲酸置于溴,铁粉体系中,化学反应生成 2-甲基-5-溴苯甲酸
参考文献:含co(II)槲皮素2,3-双加氧酶的es(酶-底物)复合物的结构和功能模型系列
标题:含co(II)槲皮素2,3-双加氧酶的es(酶-底物)复合物的结构和功能模型系列
摘要:一系列的单核的co Ii-Flavonolate络合物[co Ii大号-[r(fla)](大号ř ħ = 2-{[双(吡啶-2-基甲基)氨基]甲基}-P /米-R-苯甲酸; R = P-Ome(1),P-Me(2),M-Br(4)和m-No 2(5); Fla =黄酮酸酯)被设计并合成为es(酶-底物)复合物的结构和功能模型,以模拟含co(II)的槲皮素2,3-二加氧酶(co-2,3-Qd)的活性位点.每个络合物中的金属中心co(II)离子显示出相似的扭曲八面体几何形状.模型复合物在低温下显示出高的酶型双加氧反应性(配位底物黄酮酸酯的氧化o-杂环开环),这可能是由于配体中的羧酸酯基团所致.反应性表现出依赖于取代基的顺序-Ome(1)>-Me(2)>-H(3)14B>-Br(4)>-No 2(5),而hammett图是线性的(ρ= −0.78).这可以解释为配体
DOI:10.1021/ic402695C

专利信息

专利号:EP-2918579-A1
优先权日:2014-03-14
标题 :Synthesis of 2-arylmethyl-5-aryl-thiophene
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides a new synthetic process for the production of 2-arylmethyl-5-aryl-thiophene, an intermediate in the synthesis of C-aryl glycosides.

专利号:WO-2024175691-A1
优先权日:2023-02-24
标题 :Process for the preparation of substituted chalcones
发明人：BOBNAR JERNEJ
权利人:KRKA D D NOVO MESTO
摘要:The invention relates to an improved process for the preparation of substituted chalcones using a base that plays double role in the process, as it removes free water and catalyzes aldol condensation. Consequently, the process is cost efficient and is easily scalable to industrial level. The substituted chalcones are useful intermediates in the synthesis of isoxazolines such as Fluralaner, Afoxolaner and Sarolaner, which are known systemic insecticides and acaricides.

专利号:US-2017247359-A1
优先权日:2014-09-05
标题 :Process for the preparation of canagliflozin
发明人：VELLANKI SIVA RAM PRASAD; BALUSU RAJA BABU; PILLI RAMAKRISHNA; JAWAJI RAJESWARA ROA; ANNADASU ANKAMA NAYUDU
权利人:MYLAN LABORATORIES LTD
摘要:A process for the preparation of canagliflozin. The process may be effectively implemented on an industrial scale. Several compounds useful as intermediates for the synthesis of canagliflozin (Formula 4, Formula 4a, Formula 4b and Formula 5) are also disclosed. The process involves the reduction of the compound of formula 3 in the presence of a metal hydride and an organic solvent to obtain the compound of formula 4, converting this into a compound of formula 5 which in turn is converted into canagliflozin.

专利号:US-2024400552-A1
优先权日:2016-11-11
标题 :Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11622968-B2
优先权日:2011-03-08
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-10226449-B2
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
发明人：HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.