2,2-Diethylisoxazolidinium置于palladium On Activated Charcoal 氢气体系中,用 水 作为反应溶剂,化学反应生成 3-二乙氨基-1-丙醇 参考文献:Ishidate,M. Et Al.,Chemical And Pharmaceutical Bulletin,1961,Vol. 9,P. 485-491 标题:Ishidate,M. Et Al.,Chemical And Pharmaceutical Bulletin,1961,Vol. 9,P. 485-491
专利号:US-7825244-B2 优先权日:2005-06-10 标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis 发明人:BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG 权利人:JANSSEN PHARMACEUTICA NV 摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.
专利号:US-6538094-B2 优先权日:1998-12-21 标题:Process for synthesis of allophanate compounds and compositions including the product thereof 发明人:TAZZIA CHARLES L 权利人:BASF CORP 摘要:The invention provides a process for preparing an allophanate-containing compound in the presence of a metal catalyst and a tertiary amine. In a preferred process, the tertiary amine compound also has a hydroxyl group. The hydroxyl group can react with the isocyanate functionality. Also disclosed is a process in which an allophanate-containing compound is prepared with copper acetate monohydrate as a catalyst. The allophanate-containing compound is used as a curing agent in coating compositions, particularly electrocoat coating compositions. The coating compositions are used to coat articles.
专利号:US-3721650-A 优先权日:1971-03-22 标题 :Reactive hydroxyalkyl-onium catalysts for synthesis of polyoxazolidones 发明人:D ALELIO G 权利人:ALELIO G D 摘要:A PROCESS FOR PREPARING POLYOXAZOLIDONES IS PROVIDED IN WHICH A POLYEPOXIDE IS REACTED WITH A POLYISOCYANATE IN THE PRESENCE OF CHEMICALLY REACTIVE HYDROXYALKYL-ONIUM CATALYSTS, SELECTED FROM THE CLASS OF AMMONIUM AND PHOSPHONIUM HALIDES HAVING AT LEAST TWO HYDROXYALKYL GROUPS. NOVEL POLYMERS ARE OBTAINED WHEN THESE NEW CATALYSTS CONTAINING TWO OR MORE HYDROXY GROUPS ARE CONDENSED WITH POLYISOCYANATES.
专利号:US-7067554-B2 优先权日:2000-05-30 标 题 :Method for the synthesis of compounds of formula I and their uses thereof 发明人:MJALLI ADNAN M M; GOPALASWAMY RAMESH; AVOR KWASI A; WYSONG CHRISTOPHER L; ANDREW PATRON 权利人:TRANSTECH PHARMA INC 摘要:This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, β-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.
专利号:US-5637757-A 优先权日:1995-04-11 标 题 :One-pot synthesis of ring-brominated benzoate compounds 发明人:HILL JOHN E; FAVSTRITSKY NICOLAI A; MAMUZIC RASTKO I; BHATTACHARYA BHABATOSH 权利人:GREAT LAKES CHEMICAL CORP 摘要:A method of preparing tetrabromobenzoate compounds from tetrabromophthalic anhydride by reacting tetrabromophthalic anhydride with alcohol in the presence of a decarboxylation catalyst. The reaction may be carried out in an excess of alcohol, or with a near stoichiometric amount of alcohol by performing the reaction in an inert solvent.
专利号:US-2007021436-A1 优先权日:2005-06-10 标 题 :Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
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