专利号:US-2019047933-A1 优先权日:2016-03-15 标 题:Process for the synthesis of (2e, 4e, 6z, 8e)-8-(3,4-dihydronaphthalen-1(2h)-ylidene)-3,7-dimethylocta-2, 4, 6-trienoic acid 发明人:ABEL ULRICH; RÉPÃ?SI JÓZSEF; Szabó András; SZÜCSNÉ CSERÉPI STEFÃ?NIA; Bor Ã?dám 权利人:ABEL ULRICH; REPASI JOZSEF; SZABO ANDRAS; SZUECSNE CSEREPI STEFANIA; BOR ADAM; BRICKELL BIOTECH INC 摘要:This invention relates to a novel method for the synthesis of (2E,4E,6Z,8E)-8-(3,4-dihydronaphthalen-1(2H)-ylidene)-3,7-dimethylocta-2,4,6-trienoic acid. In particular, the invention relates to several improvements in several individual steps of the multi-step synthesis scheme
专利号:EP-0596485-B1 优先权日:1992-11-05 标题 :Electrochemical process for preparing alcoholates of alkaline metal and use thereof for regenaration of the catalyst in the synthesis of methylformat 发明人:SOBOTTA GEORG DR-ING; PAZDERSKI JURI ANTONOWITSCH PR; SKATSCHKO WLADIMIR PETROWITSCH; LEZJUK WASSILI WLADIMIROWITSCH; TAGAJEW OLEG ALEXEJEWITSCH DR 权利人:SALZGITTER ANLAGENBAU; SYNTHEZ BNII 摘要:The invention relates to a process for the electrochemical synthesis of alkali metal alcoholates (alkoxides) and/or for the regeneration of the catalyst from methyl formate synthesis from alcoholic solutions of salts of alkali metals in an electrolysis apparatus with an ion-selective membrane. The electrolysis is carried out in the presence of a defined quantity of a potassium salt or sodium salt of a perfluoroalkanesulphonic acid accompanied by the use of non-oxidisable anode material and with a membrane based on a sulphonated styrene-divinylbenzene copolymer. The process enables an increase in the selectivity of the procedure and a continuous synthesis.
专利号:US-2024400517-A1 优先权日:2022-02-08 标 题 :Chiral bimetallic cooperative catalysis system and use thereof in asymmetric synthesis of bedaquiline 发明人:ZHANG WANBIN; GAO FENG; LI JING; AHMAD TANVEER; ZHANG ZHENFENG; YUAN QIANJIA 权利人:UNIV SHANGHAI JIAOTONG 摘要:A chiral bimetallic cooperative catalysis system and use thereof in asymmetric synthesis of bedaquiline are provided. Specifically, the chiral bimetallic cooperative catalysis system is formed by a metallic lithium, sodium or potassium salt and another metal salt under the action of a suitable ligand and an additive. By means of the chiral bimetallic cooperative catalysis system, an addition reaction of 6-bromo-3-benzyl-2-methoxyquinoline (I) and 3-dimethylamino-1-naphthyl-1-propanone (II) is promoted, the selectivity is regulated, and a target product, (1R,2S)-bedaquiline, with high yield and high selectivity is obtained for the first time.
专利号:US-5491243-A 优先权日:1993-10-12 标题 :Intermediate useful for the asymmetric synthesis of duloxetine 发明人:BERGLUND RICHARD A 权利人:LILLY CO ELI 摘要:This invention provides a stereospecific process for the synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, a key intermediate in the synthesis of duloxetine.
专利号:US-2012123121-A1 优先权日:2009-06-12 标题:Synthesis of picoplatin 发明人:LEIGH ALISTAIR J; JOST STEFFEN 权利人:LEIGH ALISTAIR J; JOST STEFFEN; PONIARD PHARMACEUTICALS INC 摘要:An improved method for the synthesis of the anticancer drug picoplatin is provided. Condensation of a tetrachloroplatinate salt (TCP), such as potassium tetrachloroplatinate, and 2-picoline, in a solvent, is catalyzed by the presence of oxygen, such as in air, and additionally catalyzed by the presence of a Pt +4 complex, such as potassium hexachloroplatinate. The oxygen can be introduced into the reaction mixture by sparging, optionally with high shear mixing and under an inert gas headspace. The product trichloropicolineplatinate salt (TCPP) is a key intermediate in the synthesis of picoplatin, to which it can be converted by reaction of the TCPP with ammonia.
专利号:US-7122693-B2 优先权日:1988-04-11 标题 :Acetaldehyde acetal compounds, their synthesis, and uses thereof 发明人:BELLEAU EXECUTRIX OF ESTATE PI; DIXIT DILIP M; NGUYEN-BA NGHE 权利人:SHIRE BIOCHEM INC 摘要:The acetaldehyde compounds, 2-thiobenzoylacetaldehyde diethylacetal, 2-benzoyloxyacetaldehyde bis(2-methoxyethyl)acetal, 2-hydroxyacetaldehyde bis( 2-methoxyethyl)acetal, 2-thiobenzoylacetaldehyde bis(2-methoxy-ethyl)acetal, and 2-thioacetaldehyde bis(2-methoxyethyl)acetal, are useful as intermediates in the synthesis of substituted 1,3-oxathiolanes and substituted 1,3-dioxolanes.
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合成参考文献
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