CAS: 577-71-9; 3,4-Dinitrophenol

上下游产品

meta-nitrophenol 2,3-dinitrophenol 3,4-dinitrophenyl cinnamate 3,4-dinitrophenyl 2,4,6-trinitrophenyl ether styphnic acid 2,4,5-trinitrophenol 3,4-diaminophenol 2,6-dibromo-3,4-dinitro-phenol

📜在 Human Recombinant O-Glcnacase,Wild Type体系中,用 二甲基亚砜 作为反应溶剂,化学反应生成 3,4-二硝基苯酚
参考文献:使用多重线性自由能关系探索糖苷水解酶o-Glcnacase中两种催化策略之间的协同作用
标题:使用多重线性自由能关系探索糖苷水解酶o-Glcnacase中两种催化策略之间的协同作用
摘要:人类 O-Glcnacase 在调节丝氨酸和苏氨酸残基与 β-O 连接的 N-乙酰氨基葡萄糖单糖单元 (O-Glcnac) 的翻译后修饰方面发挥着重要作用.o-Glcnacase 的机制涉及底物的 2-乙酰氨基基团的亲核参与以取代糖苷连接的离去基团.这种酶对底物结构变化的耐受性使我们能够使用几个系列的底物来表征 O-Glcnacase 过渡态,以产生多个同时的自由能关系.观测到伴随亲核强度和离去基团能力变化的机制,过渡态和速率决定步骤的变化模式.观测到的机制变化反映了酶通酸和催化亲核试剂所起的作用.重要的是,这些结果说明了酶如何协同利用两种催化模式;许多小分子催化模型都没有的特征.这些研究还表明了氧代碳鎓离子中间体在 O-Glcnacase 催化的氨基葡萄糖水解中的动力学意义,探索了使用酶过渡态结构的非原子研究可能学到的知识的局限性,并提供了关于保留超家族的一般见解糖苷水解酶作为有效的催化剂.
DOI:10.1021/ja904506U

专利信息

专利号:US-5635157-A
优先权日:1992-04-13
标 题 :Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging
发明人：MEASE RONNIE C; KOLSKY KATHRYN L; MAUSNER LEONARD F; SRIVASTAVA SURESH C
摘要:Cyclohexyl chelating agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N, N, N', N'-tetra acetic acid.

专利号:KR-101499065-B1
优先权日:2013-06-21
标题:Alpha-Thioglycoligase-based Synthesis of O-Aryl alpha-Glycosides

专利号:US-8372380-B2
优先权日:2007-03-30
标 题:In vivo imaging of sulfotransferases
发明人：BARRIO JORGE R; KEPE VLADIMIR; SMALL GARY W; SATYAMURTHY NAGICHETTIAR
权利人:UNIV CALIFORNIA; BARRIO JORGE R; KEPE VLADIMIR; SMALL GARY W; SATYAMURTHY NAGICHETTIAR
摘要:Radiolabeled tracers for sulfotransferases (SULTs), their synthesis, and their use are provided. Included are substituted phenols, naphthols, coumarins, and flavones radiolabeled with 18 F, 123 I, 124 I, 125 I, or 11 C. Also provided are in vivo techniques for using these and other tracers as analytical and diagnostic tools to study sulfotransferase distribution and activity, in health and disease, and to evaluate therapeutic interventions.

专利号:KR-20140148029-A
优先权日:2013-06-21
标题 :Alpha-Thioglycoligase-based Synthesis of O-Aryl alpha-Glycosides

专利号:US-5292938-A
优先权日:1992-04-13
标题 :Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging

专利号:US-4536355-A
优先权日:1982-10-08
标题 :Phenoxyphenylaminoalkylphosphinates useful in weed control
发明人：LEE SHY-FUH; HENRICK CLIVE A
权利人:ZOECON CORP
摘要:Novel phenoxyphenoxyalkyl-, phenoxyphenylthioalkyl- or phenoxyphenylsulfonylalkyl-substituted phosphinates and phosphonates, related compounds, synthesis thereof, intermediates therefor, and the use of said novel compounds for the control of weeds.