CAS: 56-05-3; 2-Amino-4,6-Dichloropyrimidine

相似化合物

3993-78-0 10397-15-6 22404-46-2

上下游产品

CAS号56-09-7 2-氨基-4,6-二羟基嘧啶 | CAS号3764-01-0 2,4,6-三氯嘧啶 | CAS号1194-21-4 2-氨基-4-氯-6-羟基嘧啶 | CAS号4425-67-6 2-氨基-4,6(1H,5H)-嘧啶二酮 | CAS号7664-41-7 氨 | CAS号3740-92-9 解草啶 | CAS号322691-38-3 4-氯-6-(4-甲基哌嗪-1... | CAS号36314-97-3 2-氨基-4-氯-6-苯基嘧啶 | CAS号215257-64-0 4,6-bis(4-chlor... | CAS号30182-24-2 2,4-pyrimidined... | CAS号2846-77-7 2-[(2-氨基-6-氯嘧啶-... | CAS号339016-18-1 4-氯-6-吗啉嘧啶-2-胺 | CAS号210992-85-1 4-氯-6-(苯基甲氧基)-2-嘧啶胺 | CAS号89784-02-1 4-氯-6-乙氧基嘧啶-2-胺 | CAS号7781-26-2 5-溴-4,6-二氯嘧啶-2-胺

Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于三氯氧磷体系中,化学反应生成 2-氨基-4,6-二氯嘧啶
参考文献:Buettner,Chemische Berichte,1903,Vol. 36,P. 2234
标题:Buettner,Chemische Berichte,1903,Vol. 36,P. 2234

专利信息

专利号:US-6818633-B2
优先权日:2001-06-29
标题:Antiviral compounds and methods for synthesis and therapy
发明人：BALZARINI JAN M R; DE CLERCQ ERIK D A; HOLY ANTONIN
权利人:ACAD OF SCIENCE CZECH REPUBLIC; REGA STICHTING
摘要:Novel compounds are provided having formula (I)whereR1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).

专利号:WO-0119801-A1
优先权日:1999-09-16
标题 :Bioactive substance containing derivatives of 2-amino-6-aryloxypyrimidines and intermediary products of synthesis thereof
发明人：ASHKINAZI RIMMA ILIINICHNA; GANINA MARIYA BORISOVNA; STUDENTSOV EVGENY PAVLOVICH
权利人:ASHKINAZI RIMMA ILIINICHNA; GANINA MARIYA BORISOVNA; STUDENTSOV EVGENY PAVLOVICH
摘要:The invention relates to novel bioactive compounds of the family of pyrimidines and to intermediary products, of the synthesis of such compounds. The novel compounds have a strong antimicrobial activity (especially in respect to a strain of mycobacterium resisting to the existing drugs) and a strong antiviral activity in addition to a strong immunostimulating (interferonogenic) activity while at the same time having a low toxicity level. The derivatives of 2-amino-6-aryloxypyrimidines and intermediary products of the synthesis of such compounds correspond to the following general formula: (formula I) where R1 is preferably selected from a group containing amino, C1-C4 monoalkylamino, dialkylamino, carboxyalkylamino, arylamino, heterylamino groups; R2 represents halogen atoms or an alkyl, hydroxyl, amino or alkoxy group; R3 represents hydrogen or halogen atoms; R4 represents halogen atoms, aryloxy groups with functional X substituents in ortho-, meta- and para positions of the aryl fragment, whereby X substituents are halogen atoms, alkyls C1-C4, cycloalkyl, alkenyl, alkoxy and nitro groups. The invention also relates to the pharmaceutically acceptable salts thereof.

专利号:WO-2012127472-A1
优先权日:2011-03-22
标题:Process and intermediates for the preparation of preladenant and related compounds
发明人：MAROM EHUD; MIZHIRITSKII MICHAEL; RUBNOV SHAI
权利人:MAPI PHARMA LTD; MAROM EHUD; MIZHIRITSKII MICHAEL; RUBNOV SHAI
摘要:The present invention describes processes for the synthesis of 2-(furan-2-yl)-7-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-l-yl] ethyl]-7H-pyrazolo[ 4,3-e ][1,2,4]- triazolo[1,5c] pyrimidin-5-amine (Preladenant) represented by the structure of formula (1 ), and solvates and salts thereof, especially salts with pharmaceutically acceptable acids. The process of the present invention is useful not only for Preladenant production, but also for the preparation of other biologically active compounds of general formula (17), such as A2a receptor antagonists used for the treatment of central nervous system diseases, among others. The present invention further relates to certain intermediates formed in such processes.

专利号:US-2023407352-A1
优先权日:2020-10-30
标题:Method for the Production of Thiocarbamate Derivatives A2AR Inhibitors
发明人：JIAO XUECHENG; DELIGNY MICHAEL; CROSIGNANI STEFANO; JIANG XIANGJUN
权利人:iTeos Belgium SA
摘要:The present disclosure relates to synthesis of enantiomerically rich key drug intermediates as a means for manufacturing of thiocarbamate derivatives as A2A adenosine receptor (A2AR) inhibitors. More particularly, the present disclosure provides a viable efficient technology using enzymatic biotransformation process which utilizes cheaper substrate for production of high value key intermediates for A2AR inhibitors.

专利号:US-7582771-B2
优先权日:2003-09-03
标题:Process for the synthesis of cPLA2 inhibitors
发明人：DEHNHARDT CHRISTOPH M; MEGATI SREENIVASULU; MICHALAK RONALD S; RAVEENDRANATH PANOLIL; REN JIANXIN; WU CHARLES C; WU YANGZHONG
权利人:WYETH CORP
摘要:A process for making the compound of formula (I) n nwherein Ac represents acetate; X represents O or CH 2 ; Y represents C 1 -C 6 alkyl; and Z is selected from the group consisting of H, halogen, CN, CHO, CF 3 , OCF 3 , OH, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 thioalkyl, NH 2 , N(C 1 -C 6 alkyl) 2 , NH(C 1 -C 6 alkyl), NC(O)—(C 1 C 6 alkyl), and NO 2 . In his process, a compound of formula (II)n n nis reacted with hydrazine to form a primary alkylamine, and then the primary alkylamine is reacted with acetic anhydride, to produce the compound of formula (I).

专利号:US-2005049296-A1
优先权日:2003-09-03
标 题 :Process for the synthesis of cPLA2 inhibitors