CAS: 5285-18-7; 5-(Benzo[d][1,3]Dioxol-5-yl)Penta-2,4-Dienoic Acid

上下游产品

Ethyl 5-(2H-1,3-Benzodioxol-5-yl)Penta-2,4-Dienoate 6091-43-6
胡椒碱 Piperine 7780-20-3

📜胡椒碱置于水,Potassium Hydroxide体系中,用 乙醇 作为反应溶剂,化学反应 16.0H,以93%的收率获得产物5-(1,3-苯并二恶唑-5-基)-2,4-戊二烯酸
参考文献:某些与单糖类有关的酯衍生物的杀虫剂和杀螨剂的合成
标题:某些与单糖类有关的酯衍生物的杀虫剂和杀螨剂的合成
摘要:为了开发基于天然产物的农药,合成了一系列与单糖有关的酯衍生物(17A-Q和18A-F),葡萄糖(木糖)-哌酸/类似哌酸的结合物.通过单晶x射线衍射明确地确定了化合物17B,17G,17H和17N的三维结构.尤其是化合物18E和18F对mythimna Separata和tetranychus Cinnabarinus表现出最强的杀虫和杀螨活性..还讨论了它们的构效关系.
DOI:10.1016/j.Bmcl.2017.08.031

专利信息

专利号:US-2008146987-A1
优先权日:2006-12-19
标 题:Treatment of a skin condition using a piperine-based composition in conjunction with irradiation
发明人：SOUMYANATH AMALA; YOUNG ANTONY R; FAAS LAURA; VENKATASAMY RADHAKRISHNAN; HIDER ROBERT C; WALKER SUSAN
权利人:UNIV OREGON HEALTH & SCIENCE
摘要:Embodiments of the present invention are directed to methods, apparatuses, and systems for the treatment of various skin conditions by delivery of piperine and/or a related structural analog of piperine (collectively referred to as piperine-based compounds) to an area of skin affected by a skin condition (e.g., vitiligo) in conjunction with irradiation of the affected area. Structural analogs of piperine include compounds such as THP, CHP, and RCHP. In various embodiments, irradiation of affected skin in conjunction with a piperine-based composition may result in stimulation of melanin synthesis by melanocytes which may induce pigmentation to a greater extent than with the use of the piperine-based compound alone.

专利号:CN-212092018-U
优先权日:2019-12-24
标题:Mixing arrangement is used in synthesis of pepper acid

专利号:TW-200815413-A
优先权日:2006-07-07
标 题 :An enantioselective synthesis of pyrrolidines substituted with flavones, and intermediates thereof

专利号:WO-2023187830-A1
优先权日:2022-03-29
标 题:Piperic acid-conjugate with homochiral and heterochiral dipeptides containing phenylalanine and process for preparation thereof
发明人：RAI RAJKISHOR; GOSWAMI ANINDYA; RAHIM UR JUNAID; FAHEEM MIR MOHD; NAWAZ SHAH
权利人:COUNCIL SCIENT IND RES
摘要:The present invention unleashes the development of novel conjugates of piperic acid and small peptides pertinent to its application in skin cancer. This invention demonstrates the synthesis and characterization of conjugates of piperic acid with dipeptides containing L Phe and D Phe in the first part and later explores the biological activity of these said conjugates. Piperic acid- D Phe- D Phe (FC-3) conjugate is thus identified as a potential lead against skin cancer (melanoma) in vitro by delineating the anti-proliferative and anti-migratory potential together with its anti- inflammatory potential against a range of pro-inflammatory interleukins (IL-1β, IL-6, and IL-8). The in vivo efficacy of FC-3 is validated in the two-step (DMBA/TPA) chemically induced mouse skin cancer model.

专利号:US-10399992-B2
优先权日:2016-04-11
标题:Process for preparing AD-35
发明人：ZHONG JINQING; ZHAO XUYANG; BAI HUA; GONG YONGXIANG; ZHANG XINLONG; ZHU QIFENG; LIU WEIWEI; ZHOU YA
权利人:ZHEJIANG HISUN PHARM CO LTD
摘要:Disclosed are a method for preparing a benzodioxole derivative (AD-35) shown by Formula (I) and an intermediate thereof. The method of the present invention involves: using piperic acid as a raw material; and performing bromination, esterification, cyanidation, cyclopropane lactamization, amide nitrogen alkylation, deprotection, piperidine nitrogen alkylation and salification to obtain the compound of Formula (I). The method has cheap and easily available start raw materials, short synthesis routes and simple operation, and is suitable for industrial production.

专利号:CN-119874466-A
优先权日:2025-01-13
标 题 :A kind of N,N-dimethylamide compound and its synthesis method