CAS: 520-33-2; (S)-5,7-Dihydroxy-2-(3-Hydroxy-4-Methoxyphenyl)Chroman-4-One

该化合物是一粒花草甘蓝, 展示出潜在的抗氧化性强效特性, 可用于预防氧化性应激相关疾病. 它的独特结构使得免费基的清除和细胞信号路径的调制得到加强,使它成为心血管健康和炎症调控等领域进一步研究的诱人化合物.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号520-26-3 橙皮苷 | CAS号90-33-5 4-甲基伞形酮 | CAS号161713-86-6 alpha-Glucosyl ... | CAS号71-23-8 正丙醇 | CAS号64-17-5 乙醇 | CAS号71-41-0 正戊醇 | CAS号67-63-0 异丙醇 | CAS号100-51-6 苯甲醇 | CAS号35400-60-3 3-(3-hydroxy-4-... | CAS号603-61-2 柽柳素 | CAS号520-34-3 香叶木素 | CAS号17060-20-7 2-(3,4-dimethox... | CAS号70411-27-7 4'-O-甲基花旗松素 | CAS号70412-86-1 potassium 3-[5-...

合成工艺路线路线简述

  • 合成目标产物 Hesperetin 主要起始原料 Hesperidin
  • 520-26-3 + 10236-47-2 = 520-33-2 + 480-41-1 + 90-74-4
    反应条件:1.1 Catalysts: Glucosidase,β- Solvents: Dimethyl Sulfoxide,Water; 90 Min,Ph 5.5,95 °C
    标题:Hydrolysis Of Flavanone Glycosides By β-Glucosidase From Pyrococcus Furiosus And Its Application To The Production Of Flavanone Aglycones From Citrus Extracts
    作者:Shin,Kyung-Chul; Nam,Hyun-Koo; Oh,Deok-Kun
    参考文献:Journal Of Agricultural And Food Chemistry 日期:2013 卷标:61(47) 页码:11532-11540
橙皮甙置于硫酸体系中,用 乙醇 作为反应溶剂,化学反应生成 橙皮素
参考文献:与锰络合提高木犀草素的抗氧化活性,抗菌活性和降血糖作用(II)及其对黄嘌呤氧化酶的抑制动力学
标题:与锰络合提高木犀草素的抗氧化活性,抗菌活性和降血糖作用(II)及其对黄嘌呤氧化酶的抑制动力学
摘要:本研究旨在通过与锰(II)的络合提高木犀草素的生物活性.通过紫外可见光谱,红外光谱,热重分析和元素分析来评估木犀草素和锰(II)离子与螯合位点的相关相互作用.研究并比较了木犀草素-锰(II)配合物对其母体木犀草素的抗氧化活性,降血糖作用和抗菌活性,以及它们对黄嘌呤氧化酶的抑制作用.光谱数据表明与锰(木犀草素发生反应ii)阳离子通过两个木犀草素分子中的5-羟基和4-羰基的螯合位点.锰(II)阳离子与木犀草素络合后,抗氧化和抗菌活性得到增强.抑制作用试验发现,木犀草素和木犀草素-锰(II)配合物以竞争性方式可逆地抑制黄嘌呤氧化酶.木犀草素-锰(II)复合物通过增加肝脏组织中的葡萄糖消耗,具有比木犀草素更显着的降血糖作用.
DOI:10.1039/c7Ra11036G

海关参考信息

专利信息


专利号:US-9149659-B2
优先权日:2012-11-14
标题 :Cosmetic composition for increasing hyaluronic acid synthesis in skin and its use for repairing wrinkles
发明人:PUJOS MURIEL; BERNINI DOROTHEE; ROBERT CECILE; DOUCET OLIVIER
权利人:COTY GERMANY GMBH
摘要:The present invention relates to a skin composition which has an excellent effect on smoothing or repairing wrinkles. The composition comprises Palmitoyl Tripeptide-38 (Palmitoyl-Lysyl-Dioxymethionyl-Lysine) and Piper nigrum (Pepper) seed Extract which combination has been found to result in a synergistic effect on hyaluronan synthase 1 (HAS1) mRNA expression in human fibroblasts. The hyaluronan synthase is responsible for the synthesis of hyaluronan (hyaluronic acid) in skin. Hyaluronic acid is a constituent of the extracellular matrix of the skin and responsible for space filling, tissue repair and retention of moisture.

专利号:US-11773128-B2
优先权日:2019-03-28
标题 :Electrocatalytic synthesis of dihydrochalcones
发明人:REDKO MIKHAIL; SAFFRON CHRISTOPHER M; JACKSON JAMES E
权利人:UNIV MICHIGAN STATE
摘要:The disclosure relates to methods of forming a dihydrochalcone using electrocatalytic dehydrogenation. In particular, the disclosure relates to methods of forming a dihydrochalcone electrocatalytically hydrogenating (ECH) a reactant compound over a catalytic cathode in a reaction medium having a non-alkaline pH value, thereby forming a dihydrochalcone product; wherein the reactant compound has a structure according to Formula (I). The method can be used to prepare dihydrochalcone sweeteners, such as, for example, naringin dihydrochalcone and neohesperidin dihydrochalcone.

专利号:US-9700512-B1
优先权日:2016-05-10
标 题:Synthesis of hesperetin nanoparticles
发明人:Wagealla Mai Abdelrahman Elobeid; Al-Hassan Lulwah Saleh Mohammed; AWAD MANAL AHMED GASMELSEED; AL-GHAMDI NOUF ABDULLAH MUREET; VIRK PROMY; HENDI AWATIF AHMED
权利人:UNIV KING SAUD
摘要:A method of preparing hesperetin nanoparticles includes dissolving hesperetin in an organic solvent to form a solution; spraying the solution in boiling water while applying ultrasonic energy to form a mixture; and stirring the mixture for at least about 15 minutes at a speed of about 200-800 rpm to obtain the hesperetin nanoparticles.

专利号:US-2021161813-A1
优先权日:2018-08-10
标题:Comestible compositions for promoting atp synthesis
发明人:LEIGHTON HARRY J; CARTER KENNETH
权利人:MAINE NATURAL HEALTH COMPANY INC
摘要:Comestible compositions including a mitochondrial anti-oxidant, a fatty acid transport facilitator, and a substrate for ATP synthesis are disclosed. For example, a comestible composition may include D-ribose, acetyl-L-carnitine, and coenzyme Q10. Also disclosed are kits including the comestible compositions and methods of use of the comestible compositions.

专利号:FR-3002543-A1
优先权日:2013-02-28
标题:METHOD FOR THE ENZYMATIC SYNTHESIS OF FLAVONOIDS AND APPLICATION TO THE SYNTHESIS OF DIOSMETIN DERIVATIVES

专利号:US-6150403-A
优先权日:1997-10-14
标 题 :Topical compositions for regulating the oily/shiny appearance of skin
发明人:BIEDERMANN KIMBERLY A; SCHUBERT HARRY L; PARRAN JR JOHN J
权利人:PROCTER & GAMBLE
摘要:The present invention relates to methods for inhibiting sebaceous gland activity in mammalian skin comprising administration of a topical composition comprising dehydroacetic acid or pharmaceutically acceptable salts thereof, and a dermatologically-acceptable carrier. The present invention also relates to methods and topical compositions further comprising agents which regulate the oily and/or shiny appearance of skin, and agents which treat acne and related skin disorders in mammalian skin and scalp. Methods of reducing sebum synthesis with the use of dehydroacetic acid, methods of regulating the oily and/or shiny appearance of skin, and methods of treating acne and other skin disorders are also encompassed by the present invention.
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主要参考文献


1: Yang LJ, Xia S, Ma SX, Zhou SY, Zhao XQ, Wang SH, Li MY, Yang XD. Host-guest system of hesperetin and β-cyclodextrin or its derivatives: Preparation, characterization, inclusion mode, solubilization and stability. Mater Sci Eng C Mater Biol Appl. 2016 Feb 1;59:1016-24. doi: 10.1016/j.msec.2015.10.037. Epub 2015 Oct 23. doi: 10.1002/jmr.2509. Epub 2015 Sep 15. doi: 10.3892/mmr.2015.4625. Epub 2015 Nov 30. doi: 10.1016/j.jpba.2015.10.031. Epub 2015 Oct 27. doi: 10.1016/j.bmcl.2016.01.058. Epub 2016 Jan 22.

合成参考文献


参考文献:10.1186/1471-230x-11-81
摘要:Wu H, Jing Z, Tang X, Wang X, Zhang S, Yu Y, Wang Z, Cao H, Huang L, Yu Y, Wang Y. To compare the efficacy of two kinds of Zhizhu pills in the treatment of functional dyspepsia of spleen-deficiency and qi-stagnation syndrome: a randomized group sequential comparative trial. BMC Gastroenterol. 2011 Jul 15;11():81.
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