CAS: 43043-74-9; 5,8-Dihydroxy-2-(4-Methylpent-3-En-1-yl)Naphthalene-1,4-Dione

该化合物是源自Lithospermum 红红血病根部的环烷基酮衍生物,它展示了显著的生物活动,包括抗炎,抗微生物和抗直肠特性.它的行动机制包括抑制关键的细胞路径,使其成为有希望的药物研究候选体.该化合物的特点是高度纯度和稳定性,适合分析和实验应用.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号517-90-8 紫草烷

合成工艺路线路线简述

    📜(Z)-2-((2,5-Dimethoxyphenyl)Ethylidene)-6-Methylhept-5-Enoic Acid置于碘苯二乙酸,三溴化硼,三氟乙酸酐体系中,用 二氯甲烷,水,乙腈 作为反应溶剂,化学反应 3.0H,反应生成 去氧紫草素
    参考文献:一种去氧紫草素的制备方法
    标题:一种去氧紫草素的制备方法
    摘要:本发明公开了一种去氧紫草素的制备方法,采用如下工艺路线进行合成:#imgabs0#

    海关参考信息

    专利信息


    专利号:CN-108863798-A
    优先权日:2017-05-09
    标 题 :Synthesis and Biological Activity Evaluation of Shikonin Benzoyl Acrylic Acid Carboxylate Derivatives

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    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Orejarena Pacheco JC, Lahm G, Opatz T. Synthesis of alkaloids by Stevens rearrangement of nitrile-stabilized ammonium ylides: (±)-laudanosine, (±)-laudanidine, (±)-armepavine, (±)-7-methoxycryptopleurine, and (±)-xylopinine. J Org Chem. 2013 May 17;78(10):4985-92. doi: 10.1021/jo400659n. Epub 2013 May 9. doi: 10.1002/ptr.3539. Epub 2011 Jun 30. doi: 10.1186/1423-0127-16-78.
    1: Park JY, Shin MS, Hwang GS, Yamabe N, Yoo JE, Kang KS, Kim JC, Lee JG, Ham J, Lee HL. Beneficial Effects of Deoxyshikonin on Delayed Wound Healing in Diabetic Mice. Int J Mol Sci. 2018 Nov 20;19(11). pii: E3660. doi: 10.3390/ijms19113660.
    2: Vukic MD, Vukovic NL, Djelic GT, Popovic SL, Zaric MM, Baskic DD, Krstic GB, Tesevic VV, Kacaniova MM. Antibacterial and cytotoxic activities of naphthoquinone pigments from Onosma visianii Clem. EXCLI J. 2017 Feb 16;16:73-88. doi: 10.17179/excli2016-762. eCollection 2017.

    合成参考文献


    参考文献:10.1038/s41392-022-00888-1
    摘要:Yu Z, Gao J, Zhang X, Peng Y, Wei W, Xu J, Li Z, Wang C, Zhou M, Tian X, Feng L, Huo X, Liu M, Ye M, Guo D, Ma X. Characterization of a small-molecule inhibitor targeting NEMO/IKKβ to suppress colorectal cancer growth. Signal Transduction and Targeted Therapy. 2022 Mar 09;7(1):71. doi: 10.1038/s41392-022-00888-1.
    参考文献:10.1021/jf9902853
    摘要:Cho MH, Paik YS, Hahn TR. Physical stability of shikonin derivatives from the roots of Lithospermum erythrorhizon cultivated in Korea. J Agric Food Chem. 1999 Oct;47(10):4117–20. doi: 10.1021/jf9902853.
    参考文献:10.1007/s00403-008-0867-9
    摘要:Chang M, Huang H, Chang H, Chang T. Cosmetic formulations containing Lithospermum erythrorhizon root extract show moisturizing effects on human skin. Archives of Dermatological Research. 2008 Jun 10;300(6):317–23. doi: 10.1007/s00403-008-0867-9.
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