CAS: 41994-45-0; Methyl 2-Piperidinecarboxylate

相似化合物

32559-18-5 200184-53-8 180609-56-7

上下游产品

六氢吡啶-Alpha-羧酸 Pipecolic Acid 535-75-1
6-氧代-哌啶-2-羧酸甲酯 Methyl 6-Oxopiperidine-2-Carboxylate 111479-60-8

六氢吡啶-Alpha-羧酸 反应生成 2-哌啶甲酸甲酯
参考文献:Fecl 3催化的仲胺,咪唑和吡唑向2-乙酰氨基丙烯酸甲酯的共轭加成反应.β-二烷基氨基-丙氨酸和β-(n-杂芳基)-α-丙氨酸衍生物的制备
标题:Fecl 3催化的仲胺,咪唑和吡唑向2-乙酰氨基丙烯酸甲酯的共轭加成反应.β-二烷基氨基-丙氨酸和β-(n-杂芳基)-α-丙氨酸衍生物的制备
摘要:β-二烷基氨基-α-丙氨酸和β-(n-杂芳基)-α-丙氨酸衍生物是通过在铁下将基于氮的亲核试剂(环状和无环仲胺,咪唑和吡唑)共轭添加到2-乙酰氨基丙烯酸甲酯1中而获得的. (三)氯化物催化.
DOI:10.1016/0040-4020(95)00446-F

专利信息

专利号:US-8546533-B2
优先权日:2008-08-29
标 题:Pipecolic linker and its use for chemistry on solid support
发明人：MARTINEZ JEAN; ZAJDEL PAWEL; PAWLOWSKI MACIEJ; SUBRA GILLES
权利人:MARTINEZ JEAN; ZAJDEL PAWEL; PAWLOWSKI MACIEJ; SUBRA GILLES; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER 1; UNIV JAGELLONE; UNIV MONTPELLIER II
摘要:The present invention relates to a pipecolic linker and its use as a solid-phase linker in organic synthesis. Said pipecolic solid-phase linker may be used for coupling functional groups chosen between primary amines, secondary amines, aromatic amines, alcohols, phenols and thiols. In particular, said pipecolic solid-phase linker may be used for peptide or pseudopeptide synthesis, such as the reverse N to C peptide synthesis or the retro-inverso peptide synthesis, or for the synthesis of small organic molecules.

专利号:US-7943775-B2
优先权日:2006-06-21
标 题:Small molecules for imaging protein-protein interactions
发明人：LI KING C; DANTHI S NARASIMHAN
权利人:US HEALTH
摘要:A tissue is imaged to detect the presence of amyloid deposits or other target proteins prior to their aggregation into plaques, with the assistance of the administration of a labeled bifunctional compound of which one functionality binds to the target protein and the second functionality binds to a chaperone protein that is present in the tissue of interest. The two functionalities have different binding affinities, the target-binding functionality having the greater binding affinity, with the result that the bifunctional compound preferentially remains in the tissue when bound to the chaperone and then the target protein while bifunctional compound that is not bound to the target protein will leave the tissue. The inclusion of the chaperone allows the imaging process to detect the non-aggregated proteins by way of the label and the difference in kinetics of the binding to the chaperone and the target protein permits one to distinguish between binding of the bifunctional molecule to the chaperone only and binding to the chaperone and then to the target protein. Certain intermediates toward the synthesis of these bifunctional compounds are novel by themselves, and labeled bifunctional molecules in general that utilize a lysine linker are also disclosed as a novel class of compounds.

专利号:CA-2831987-C
优先权日:2011-04-04
标 题 :Method for the preparation of process intermediates for the synthesis of argatroban monohydrate

专利号:CA-2960667-A1
优先权日:2011-04-04
标题:Method for the preparation of process intermediates for the synthesis of argatroban monohydrate

专利号:CA-2960667-C
优先权日:2011-04-04
标 题:Method for the preparation of process intermediates for the synthesis of argatroban monohydrate

专利号:CA-2831987-A1
优先权日:2011-04-04
标 题:Method for the preparation of process intermediates for the synthesis of argatroban monohydrate