CAS: 33130-03-9; 3-(2,3,4-Trimethoxyphenyl)Acrylic Acid

该化合物是苯环的2,3和4个位置的三组甲氧基苯酸的代用衍生物,其特点是三组苯氧基苯丙酸,该化合物对有机合成和制药研究很感兴趣,因为它在培养生物活性分子,包括氟氯素和其他多酚衍生物方面发挥着多种中间作用,其甲氧基组提高了电子密度,影响结合和凝聚反应的再活动.该化合物在极地有机溶剂中表现出中度溶性,便于其用于合成用途.其结构特征使得它对于研究药用化学中的结构活动关系和作为精细化学合成的前体很有价值.

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CAS号141-82-2 丙二酸 | CAS号2103-57-3 2,3,4-三甲氧基苯甲醛

合成工艺路线路线简述

  • 合成目标产物 Trans-2,3,4-Trimethoxycinnamic Acid 主要起始原料 Malonic Acid And 2,3,4-Trimethoxybenzaldehyde
  • (文献来源)合成步骤主要原料 Malonic Acid 和 2,3,4-Trimethoxybenzaldehyde
📜丙二酸,2,3,4-三甲氧基苯甲醛置于哌啶体系中,用 吡啶 用作溶剂,化学反应生成2,3,4-三甲氧基肉桂酸
参考文献:Synthesis,Biological Evaluation And Mechanism Study Of A Class Of Benzylideneindanone Derivatives As Novel Anticancer Agents
标题:Synthesis,Biological Evaluation And Mechanism Study Of A Class Of Benzylideneindanone Derivatives As Novel Anticancer Agents
摘要:我们的发现揭示了苄亚甲基吲哚酮基团作为一种新的吸引人的骨架,用于有针对性地发现有丝分裂靶向药物.
Doi:10.1039/c5Md00139K

海关参考信息

专利信息


专利号:US-4400550-A
优先权日:1982-02-12
标题 :Synthesis of the navel orange worm pheromone (Z,Z)-11,13-hexadecadienal
发明人:BISHOP CLYDE E; MORROW GARY W
权利人:ALBANY INT CORP
摘要:A process for the synthesis of (Z,Z)-11-13-hexadecadienal is disclosed, starting with undecylenic alcohol.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-RE29558-E
优先权日:1973-03-06
标 题:Lincomycin analogs
摘要:Compounds of the formula: ##STR1## are disclosed, wherein R 1 taken independently is hydrogen; R 2 taken independently is the moiety ##STR2## wherein Ac is carboxacyl or an acyl group of formula: ##STR3## wherein Z is hydrogen, lower alkyl or a protective group removable by hydrogenolysis; R 5 is lower alkyl; R 1 and R 2 when together are the divalent group; ##STR4## wherein Z and R 5 are as defined above; R 3 is hydrogen when R 1 and R 2 are taken together and is a monovalent thio group of formula: ##STR5## located in the 7(S)-position when R 1 and R 2 are taken independently, A represents hydrogen or hydroxyl, B represents hydrogen or hydroxyalkyl, n is the integer 0 when B is hydroxyalkyl and n is an integer of 0 to 1, inclusive, when B is hydrogen, X is oxygen .[.or sulfur.]., D is the acyl radical of a lower hydrocarbon carboxylic acid; R 4 is lower alkyl and Y is carboxacyl or hydrogen. n Disclosed also are methods of making and using the novel compounds of the invention, which are useful intermediates in the chemical synthesis of useful antibacterial lincomycin analogs. Certain of the compounds of the invention are also active as antibacterial agents.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-4169197-A
优先权日:1977-09-06
标 题:6-Deoxyneamines aminoglycoside compounds
发明人:MAGERLEIN BARNEY J
权利人:UPJOHN CO
摘要:6-Deoxyneamine, 6-deoxy-5-epineamine, their 5-O-glycosyl derivatives, 6-deoxy-5-oxoneamine and the derivatives therefrom are useful as antibacterial agents and/or as intermediates in the synthesis of antibacterially active 6-deoxyneamines.

专利号:US-4232148-A
优先权日:1979-03-05
标题 :6-Deoxyneamines
发明人:MAGERLEIN BARNEY J
权利人:UPJOHN CO
摘要:6-Deoxyneamine, 6-deoxy-5-epineamine, their 5-0-glycosyl derivatives, 6-deoxy-5-oxoneamine and the derivatives therefrom are useful as antibacterial agents and/or as intermediates in the synthesis of antibacterially active 6-deoxyneamines.

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📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


摘要:Huy, P.; Czekelius, C., Science of Synthesis Knowledge Updates, (2019) 2, 129.
参考文献:10.1021/bi050941u
摘要:Kumar S, Arya P, Mukherjee C, Singh BK, Singh N, Parmar VS, Prasad AK, Ghosh B. Novel aromatic ester from Piper longum and its analogues inhibit expression of cell adhesion molecules on endothelial cells. Biochemistry. 2005 Dec 06;44(48):15944–52. doi: 10.1021/bi050941u.
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