📜丙二酸,2,3,4-三甲氧基苯甲醛置于哌啶体系中,用 吡啶 用作溶剂,化学反应生成2,3,4-三甲氧基肉桂酸 参考文献:Synthesis,Biological Evaluation And Mechanism Study Of A Class Of Benzylideneindanone Derivatives As Novel Anticancer Agents 标题:Synthesis,Biological Evaluation And Mechanism Study Of A Class Of Benzylideneindanone Derivatives As Novel Anticancer Agents 摘要:我们的发现揭示了苄亚甲基吲哚酮基团作为一种新的吸引人的骨架,用于有针对性地发现有丝分裂靶向药物. Doi:10.1039/c5Md00139K
专利号:US-4400550-A 优先权日:1982-02-12 标题 :Synthesis of the navel orange worm pheromone (Z,Z)-11,13-hexadecadienal 发明人:BISHOP CLYDE E; MORROW GARY W 权利人:ALBANY INT CORP 摘要:A process for the synthesis of (Z,Z)-11-13-hexadecadienal is disclosed, starting with undecylenic alcohol.
专利号:US-6531470-B1 优先权日:1998-01-23 标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:US-RE29558-E 优先权日:1973-03-06 标 题:Lincomycin analogs 摘要:Compounds of the formula: ##STR1## are disclosed, wherein R 1 taken independently is hydrogen; R 2 taken independently is the moiety ##STR2## wherein Ac is carboxacyl or an acyl group of formula: ##STR3## wherein Z is hydrogen, lower alkyl or a protective group removable by hydrogenolysis; R 5 is lower alkyl; R 1 and R 2 when together are the divalent group; ##STR4## wherein Z and R 5 are as defined above; R 3 is hydrogen when R 1 and R 2 are taken together and is a monovalent thio group of formula: ##STR5## located in the 7(S)-position when R 1 and R 2 are taken independently, A represents hydrogen or hydroxyl, B represents hydrogen or hydroxyalkyl, n is the integer 0 when B is hydroxyalkyl and n is an integer of 0 to 1, inclusive, when B is hydrogen, X is oxygen .[.or sulfur.]., D is the acyl radical of a lower hydrocarbon carboxylic acid; R 4 is lower alkyl and Y is carboxacyl or hydrogen. n Disclosed also are methods of making and using the novel compounds of the invention, which are useful intermediates in the chemical synthesis of useful antibacterial lincomycin analogs. Certain of the compounds of the invention are also active as antibacterial agents.
专利号:US-6562844-B2 优先权日:1998-01-23 标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:US-4169197-A 优先权日:1977-09-06 标 题:6-Deoxyneamines aminoglycoside compounds 发明人:MAGERLEIN BARNEY J 权利人:UPJOHN CO 摘要:6-Deoxyneamine, 6-deoxy-5-epineamine, their 5-O-glycosyl derivatives, 6-deoxy-5-oxoneamine and the derivatives therefrom are useful as antibacterial agents and/or as intermediates in the synthesis of antibacterially active 6-deoxyneamines.
专利号:US-4232148-A 优先权日:1979-03-05 标题 :6-Deoxyneamines 发明人:MAGERLEIN BARNEY J 权利人:UPJOHN CO 摘要:6-Deoxyneamine, 6-deoxy-5-epineamine, their 5-0-glycosyl derivatives, 6-deoxy-5-oxoneamine and the derivatives therefrom are useful as antibacterial agents and/or as intermediates in the synthesis of antibacterially active 6-deoxyneamines.