专利号:US-6306179-B1 优先权日:1997-10-22 标题:Method for the synthesis of 2-hydroxyalkyl-para-phenylenediamines, new 2-hydroxyalkyl-para-phenylenediamines, their use for oxidation dyeing, dyeing compositions and methods of dyeing 发明人:GENET ALAIN; LAGRANGE ALAIN 权利人:OREAL 摘要:The present invention relates to a new method for the synthesis of 2-hydroxyalkyl-para-phenylenediamines which are substituted or unsubstituted at the 5-position of the benzene ring, new 2-hydroxyalkyl-para-phenylenediamines which are substituted or unsubstituted at the 5-position of the benzene ring, their use for the oxidation dyeing of keratinous fibers, the dyeing compositions containing them, as well as the methods of dyeing using them.
专利号:US-9790206-B2 优先权日:2013-02-27 标 题:Intermediates for use in the preparation of indazole derivatives and processes for the preparation thereof 发明人:EARY C TODD; HACHE BRUNO P; JUENGST DERRICK; SPENCER STACEY RENEE; STENGEL PETER J; WATSON DANIEL JOHN 权利人:ARRAY BIOPHARMA INC 摘要:Provided herein are novel processes for preparing a compound of Formula (I) to the use of said compound as an intermediate in novel processes for the synthesis of indazole derivatives, and to indazole intermediates and derivatives prepared by the processes described herein.
专利号:US-7550510-B2 优先权日:2001-07-06 标 题 :Solid phase synthesis of arylretinamides 发明人:CURLEY JR ROBERT W; MERSHON SERENA M; BARNETT DEREK W; CLAGETT-DAME MARGARET; CHAPMAN JASON S 权利人:WISCONSIN ALUMNI RES FOUND 摘要:A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent; reacting retinoic acid with the activated chlorinating reagent to provide retinoyl chloride; adding pyridine and a select arylamine to the resulting mixture; and stirring the resulting mixture for a time and at a temperature sufficient for the select arylamine to react with the retinoyl chloride and provide the arylretinamide. Also provided, are select arylretinamides that can be prepared by the present method, and methods of using such arylretinamides to induce apoptosis in cancer cells.
专利号:US-4764263-A 优先权日:1987-05-18 标 题:Electrochemical synthesis of substituted aromatic amines in basic media 发明人:GREGORY THOMAS D; STUTTS KENNETH J 权利人:DOW CHEMICAL CO 摘要:Substituted amino aromatic compounds such as 3-amino-4-hydroxybenzoic acid are prepared by electrolytically reducing the corresponding nitro aromatic compound in a basic medium at temperatures below 60° C. and current densities greater than 50 milliamps per square centimeter. The aminohydroxybenzoic acids are useful in the preparation of polybenzoxazoles which are used to make fibers and composites having high strength and thermal stability.
专利号:US-2007243147-A1 优先权日:2004-07-24 标 题:Skin and/or Hair Composition Containing Compounds for Increasing The Tanning of Skin 发明人:WOLBER RAINER; TOM DIECK KAREN; SCHERNER CATHRIN; SCHLENZ KATHRIN; KRUSE INGE 权利人:BEIERSDORF AG 摘要:The invention relates to agents that are to be applied to the skin or hair and contain compounds for intensifying tanning of the skin and increasing melanin synthesis in skin or hair. The invention particularly relates to cosmetic or dermatological preparations. Using said preparations results in inducing and intensifying the tanning mechanisms of the skin, intensifying the hair color, and thus also increasing intrinsic protection of the skin or hair.
专利号:US-2007189984-A1 优先权日:2003-09-08 标题:Agents for use on skin and/or hair containing quadruply substituted cyclohexene compounds 发明人:WOLBER RAINER; SCHERNER CATHRIN; TOM DIECK KAREN; SCHLENZ KATHRIN; VIETZKE JENS-PETER 权利人:BEIERSDORF AF 摘要:The invention relates to agents for use on skin or hair, particularly for increasing skin tanning and the synthesis of melanin in skin or hair. The invention contains, in particular, cosmetic or dermatological preparations containing quadruply substituted cyclohexene compounds. The use of the preparations leads to the induction and intensification of the tanning mechanisms of skin, the intensification of hair color and thus also to an intensification of the skin's and hair's intrinsic protection.
[参考文献]: Robert A Kanaly, Et Al. Biotransformation Of 3-Methyl-4-Nitrophenol, A Main Product Of The Insecticide Fenitrothion, By Aspergillus Niger. J Agric Food Chem. 2005 Aug 10;53(16):6426-31. [参考文献]: Y Ohkuma, Et Al. Distinct Mechanisms Of Oxidative Dna Damage By Two Metabolites Of Carcinogenic O-Toluidine. Arch Biochem Biophys. 1999 Dec 1;372(1):97-106.
合成参考文献
摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 摘要:International Journal of Toxicology 23 (Suppl. 2):1-22, 2004