CAS: 2403-22-7; N-Butylbenzylamine

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CAS号100-52-7 苯甲醛 | CAS号109-73-9 正丁胺 | CAS号1077-18-5 1-Butanamine,N-... | CAS号100-39-0 溴化苄 | CAS号123-72-8 正丁醛 | CAS号100-46-9 苄胺 | CAS号71-36-3 正丁醇 | CAS号100-47-0 苯甲腈 | CAS号109-74-0 正丁腈 | CAS号10264-14-9 N-苄基丁酰胺 | CAS号107348-81-2 1-benzyl-1-buty... | CAS号942-92-7 苯己酮 | CAS号1083-30-3 1,3-二苯基丙-1-酮 | CAS号31844-65-2 N-benzyl-N-meth... | CAS号22014-90-0 DIBENZYL-BUTYL-AMINE | CAS号87291-11-0 1-benzyl-1-buty... | CAS号88450-76-4 1-benzyl-1-buty... | CAS号88451-06-3 1-benzyl-1-buty... | CAS号88451-07-4 1-benzyl-1-buty... | CAS号88451-08-5 1-benzyl-1-buty...

N-苄基丁酰胺置于硼烷四氢呋喃络合物,盐酸体系中,用 四氢呋喃,1,4-二氧六环,甲醇 用作溶剂,化学反应 14.5H,以81%的收率获得n-丁基苄胺
参考文献:一种温和的常规固相合成手性多胺的方法.通过还原仲酰胺来裂解硼烷-胺中间体的溶液研究.
标题:一种温和的常规固相合成手性多胺的方法.通过还原仲酰胺来裂解硼烷-胺中间体的溶液研究.
摘要:描述了在乙酸-乙酸盐缓冲溶液中使用碘进行的轻度氧化后处理方案,用于裂解硼烷-胺加合物,该硼烷-胺加合物是由硼烷促进的负载在实际的三苯甲基树脂上的聚酰胺还原而产生的.具有多种侧链官能度的手性聚胺可作为游离碱生成,而不会从固相支持物中过早释放,并且使用此方法基本上没有外消旋作用.含有各种α-氨基酸残基(val,Phe,Tyr,Ser,Cys,Met,Gln,Trp)的一系列模型低聚仲二酰胺6提供了高产率和非常好至优异纯度的三胺产物8.另一方面,含有叔酰胺(15)的底物形成了相当不寻常的三氨基硼烷中间体,该中间体需要更严格的后处理条件以释放多胺产物20.发现低聚叔酰胺如9的还原反应缓慢,但是仍然可以通过相应仲胺的原位还原胺化以高纯度获得这些化合物.与模型仲酰胺23一起在溶液中进行的对照研究证实了碘缓冲溶液的效率,并突出了与现有的裂解硼烷-胺加合物的方法相比,无需加热,无需强碱或强酸.提出了一种可能
Doi:10.1021/jo005647G

专利信息

专利号:US-8168556-B2
优先权日:2007-10-25
标 题 :Racemoselective synthesis of ansa-metallocene compounds, ansa-metallocene compounds, catalysts comprising them, process for producing an olefin polymer by use of the catalysts, and olefin homo- and copolymers
发明人：SCHULTE JOERG; SELL THORSTEN; THORN MATTHEW GRANT; WINTER ANDREAS; DIMESKA ANITA
权利人:SCHULTE JOERG; SELL THORSTEN; THORN MATTHEW GRANT; WINTER ANDREAS; DIMESKA ANITA; LUMMUS NOVOLEN TECHNOLOGY GMBH
摘要:A metallocene compound with the 4- and 7-positions on the indenyl moiety possessing large aromatic substituents is prepared in accordance with a method which produces substantially 100 percent racemic isomer. Advantageously, polymerization catalysts including the metallocene of the invention provide superior olefin polymerization results.

专利号:US-8926801-B2
优先权日:2009-01-16
标题 :Methods of electrospray chemical synthesis and device for use therein
发明人：REHMAN ATIQ
权利人:REHMAN ATIQ; CANAM BIORES INC
摘要:The present invention relates to methods of production of chemical bonds and subsequent molecules by electrospray ionization and the design of an electrospray chemical synthesizer, for use in chemical synthesis and expedited organic chemical reactions.

专利号:US-5859190-A
优先权日:1997-02-04
标题 :Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein
发明人：MEYER JEAN-PHILIPPE; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of hydantoin and thiohydantoin compounds. The present invention further provides the compounds made by the combinatorial synthesis.

专利号:US-5786448-A
优先权日:1996-11-07
标题:Combinatorial libraries of cyclic urea and cyclic thiourea derivatives and compounds therein
发明人：NEFZI ADEL; OSTRESH JOHN M; HOUGHTEN RICHARD
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of cyclic urea and cyclic thiourea compounds. The present invention further provides the compounds made by the combinatorial synthesis.

专利号:US-2010261860-A1
优先权日:2007-10-25
标题:Racemoselective synthesis of ansa-metallocene compounds, ansa-metallocene compounds, catalysts comprising them, process for producing an olefin polymer by use of the catalysts, and olefin homo- and copolymers

专利号:US-6403814-B1
优先权日:1998-10-16
标 题 :Method for synthesizing diaryl-substituted heterocyclic compounds, including tetrahydrofurans
发明人：RAO ALLA VENKATA RAMA; CHORGHADE MUKUND S; ISLAM AMIN UL; RAO VEMURI VENKATA KIRAN; PRASAD ANEGONDI SREENIVASA; RAO BATCHU VENKATESWARA; REDDY RANGA; REDDY LALATA KRISHNAKANTH; SHAILAJA KOTAKONDA; GURJAR MUKUND KESHAO; MHASKAR SUNIL VYANKATESH
权利人:MILLENNIUM PHARM INC
摘要:A method is provided for synthesizing diaryl-substituted heterocyclic compounds, particularly 2,5-diaryl-substituted tetrahydrofurans and tetrahydrothiophenes. Methods for synthesizing starting materials and intermediates are provided as well. An important application of the invention is in the synthesis of CMI-392, (±)trans-2-[5-N'-methyl-N'-hydroxyureidyl-methyl)3-methoxy-4-p-chlorophenylthioethoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran, a highly effective agent in treating inflammatory and immune disorders. The invention also encompasses novel compounds useful as starting materials and intermediates in the synthetic processes disclosed.