专利号:US-9879043-B1 优先权日:2013-06-06 标 题:Synthesis of non-natural cofactor analogs of S-adenosyl-L-methionine using methionine adenosyltransferase 发明人:THORSON JON; HUBER TYLER; ZHANG JIANJUN; Singh Shanteri 权利人:UNIV KENTUCKY RES FOUND 摘要:The present disclosure relates to the synthesis of non-natural analogs of S-adenosyl-L-methionine (SAM) and/or of Se-adenosyl-L-methionine (SeAM) by reacting a methionine analog and adenosine triphosphate (ATP) in the presence of at least one methionine adenosyltransferase (MAT), and to use thereof with downstream SAM and/or SeAM utilizing enzymes. The non-natural analogs of SAM and/or SeAM have the general formula: n nwhere X is S or Se, and R 1 is an alkyl group.
专利号:US-9988349-B2 优先权日:2014-01-03 标 题:Direct stereospecific synthesis of unprotected aziridines from olefins 发明人:ESS DANIEL HALSELL; FALCK JOHN RUSSELL; JAT JAWAHAR LAL; KURTI LASZLO 权利人:ESS DANIEL HALSELL; FALCK JOHN RUSSELL; JAT JAWAHAR LAL; KURTI LASZLO 摘要:A method for the direct stereospecific conversion of structurally diverse mono-, di-, tri- and tetra-substituted olefins to N—H, N-alkyl, N-cycloalkyl, or N-aralkyl aziridines using a hydroxylamine amination agent with transition metal catalyst. The method is operationally simple (i.e., one-pot), scalable and fast at ambient temperature.
专利号:US-7999090-B2 优先权日:2000-07-07 标 题:Fungal cell wall synthesis gene 发明人:TSUKAHARA KAPPEI; HATA KATSURA; SAGANE KOJI; NAKAMOTO KAZUTAKA; TSUCHIYA MAMIKO; WATANABE NAOAKI; OHBA FUMINORI; TSUKADA ITARU; UEDA NORIHIRO; TANAKA KEIGO; KAI JUNKO 权利人:EISAI R&D MAN CO LTD 摘要:The present invention provides isolated DNA encoding a GWT1 protein having activity to confer resistance of a fungus against a compound of formula Ia, and wherein a defect of a function of the GWT1 protein leads to a decrease in the amount of a glycosylphosphatidylinositol (GPI)-anchored protein in the cell wall of a fungus.
专利号:US-2016340305-A1 优先权日:2014-01-03 标题 :Direct stereospecific synthesis of unprotected aziridines from olefins
专利号:CN-107428649-B 优先权日:2015-03-13 标题:Process for the synthesis of novel compounds derived from 3-hydroxy-cyclopentylacetic acid
专利号:RU-2726412-C2 优先权日:2015-03-13 标题:Method of synthesis of novel compounds obtained from 3-hydroxycyclopentylacetic acid