CAS: 21714-35-2; 1-(2-Chloro-5-(Trifluoromethyl)Phenyl)Thiourea

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ammonium thi°Cyanate 3-amino-4-chlorobenzotrifluoride N-(2-chloro-5-(trifluoromethyl)phenylcarbamothioyl)benzamide N-(2-chloro-5-(trifluoromethyl)phenyl)cyanamide

📜3-氨基-4-氯三氟甲苯置于sodium Hydroxide体系中,用 水,丙酮 用作溶剂,化学反应 21.33H,反应生成1-(2-氯-5-三氟甲苯基)-2-硫脲
参考文献:N'-3-(Trifluoromethyl)Phenyl Derivatives Of N-Aryl-N'-Methylguanidines As Prospective Pet Radioligands For The Open Channel Of The N-Methyl-D-Aspartate (Nmda) Receptor: Synthesis And Structure-affinity Relationships
标题:N'-3-(Trifluoromethyl)Phenyl Derivatives Of N-Aryl-N'-Methylguanidines As Prospective Pet Radioligands For The Open Channel Of The N-Methyl-D-Aspartate (Nmda) Receptor: Synthesis And Structure-affinity Relationships
摘要:N-Methyl-D-Aspartate (Nmda) Receptor Dysfunction Has Been Linked To Several Neuropsychiatric Disorders,Including Alzheimer'S Disease,Epilepsy,Drug Addiction,And Schizophrenia. A Radioligand That Could Be Used With Pet To Image And Quantify Human Brain. Nmda Receptors In The Activated "Open Channel" State Would Be Useful For Research On Such Disorders And For The Development Of Novel Therapies,: To Date,No Radioligands Have Shown Well-Validated Efficacy For Imaging Nmda Receptors In Human Subjects. In Order To Discover Improved Radioligands For Pet Imaging,We Explored Structure Affinity Relationships In N'-3-(Trifluoromethyl)Phenyl Derivatives Of N-Aryl-N'-Methylguanidines,Seeking High Affinity And Moderate Lipophilicity,Plus Necessary Amenability For Labeling With A Positron-Emitter,Either Carbon-11 Or Fluorine-18. Among A Diverse Set Of 80 Prepared N'-3-(Trifluoromethyl)Phenyl Derivatives,Four Of These Compounds (13,19,20,And 36) Displayed Desirable Low Nanomolar Affinity For Inhibition Of [h-3](+)-Mk801 At The Pcp Binding Site And Are Of Interest For Candidate Pet Radioligand Development.
Doi:10.1021/acs.Jmedchem.5B01510