CAS: 204254-90-0; (3Ar,7R,7Ar)-Ethyl 2,2-Diethyl-7-((Methylsulfonyl)Oxy)-3A,6,7,7A-Tetrahydrobenzo[d][1,3]Dioxole-5-Carboxylate

上下游产品

pentan-3-one ethyl (3aR,7R,7aR)-2,2-dimethyl-7-methanesulfonyloxy-3a,6,7,7a-tetrahydrobenzo[1,3]dioxole-5-carboxylate (3aR,7R,7aS)-ethyl 2,2-diethyl-7-hydroxy-3a,6,7,7a-tetrahydrobenzo[d][1,3]dioxole-5-carboxylate methanesulfonyl chloride (1S,5R,6S)-5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic acid ethyl ester ethyl (3R,4R,5R)-3-(1-ethyl-propoxy)-4-hydroxy-5-methanesulfonyloxycyclohex-1-ene-1-carboxylate ethyl (3R,4S,5R)-4-azido-3-(1-ethylpropoxy)-5-hydroxy-1-cyclohexene-1-carboxylate ethyl-(3R,4S,5R)-5-azido-4-hydroxy-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate

📜右旋奎宁酸置于吡啶,磺酰氯,高氯酸,对甲苯磺酸体系中,用 乙醇,二氯甲烷,丙酮 用作溶剂,化学反应 23.0H,反应生成奥司他韦杂质58
参考文献:Method For Preventing Or Treating Arrhythmia,Method For Preventing Or Treating Atrial Fibrillation,Model Of Sustained Atrial Fibrillation,Method For Producing The Model,And Method For Screening For Atrial Fibrillation Inhibitor
标题:Method For Preventing Or Treating Arrhythmia,Method For Preventing Or Treating Atrial Fibrillation,Model Of Sustained Atrial Fibrillation,Method For Producing The Model,And Method For Screening For Atrial Fibrillation Inhibitor
摘要:预防或治疗心房颤动的方法,包括:向个体施用含有以下结构式(i)至(vi)中的一种化合物或其药理学可接受的盐的心房颤动抑制剂:其中在结构式(III)中,Gluc指的是葡萄糖醛酸.

专利信息

专利号:US-6518438-B2
优先权日:1996-08-23
标题:Preparation of cyclohexene carboxylate derivatives
发明人：KENT KENNETH M; KIM CHOUNG U; MCGEE LAWRENCE R; MUNGER JOHN D; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; KELLY DAPHNE E; WILLIAMS MATTHEW A; ZHANG LIJUN
权利人:GILEAD SCIENCES INC
摘要:The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.

专利号:US-9150498-B2
优先权日:2011-10-25
标题:Process for the preparation of oseltamivir and methyl 3-epi-shikimate
发明人：RAWAT VARUN; DEY SOUMEN; ARUMUGAM SUDALAI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses high yielding enantioselective process for synthesis of Oseltamivir from readily available starting material, cis-1,4-butene diol. The process features incorporation of chirality using sharpless asymmetric epoxidation (AE) and diastereoselective Barbier allylation and construction of cyclohexene carboxylic acid ester core through a ring closing metathesis (RCM) reaction. Further also disclosed herein is synthesis of (−)-methyl 3-epi-shikimate.

专利号:US-7473798-B2
优先权日:2005-12-28
标题:Derivatives of unsaturated, cyclic organic acids
发明人：GABEL RICHARD A; GROANING MICHAEL D; JOHNSTON DAVID A
权利人:ROCHE PALO ALTO LLC
摘要:The present invention relates to technology for preparing derivatives of unsaturated, cyclic, organic acids and salts, thereof. Shikimic acid is an example of such an acid. More particularly, the present invention relates to preparing derivatives of these acids or salts thereof that are esterified, ketalized, functionalized with a leaving group, and/or provided with epoxide functionality. Preferred aspects may be used in the synthesis of Oseltamivir Phosphate starting from shikimic acid.

专利号:US-2004053999-A1
优先权日:1997-09-17
标题 :Novel compounds and methods for synthesis and therapy
发明人：BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.