CAS: 19356-17-3; (R,Z)-3-(2-((1R,3As,7Ar,E)-1-((R)-6-Hydroxy-6-Methylheptan-2-yl)-7A-Methyloctahydro-4H-Inden-4-Ylidene)Ethylidene)-4-Methylenecyclohexan-1-Ol

上下游产品

CAS号61585-29-3 25-Hydroxyprovi... | CAS号104973-29-7 6(S),19-(N,N'-p... | CAS号104875-13-0 (2S,14S)-14-((E... | CAS号87417-16-1 (3-methyl-3-((t... | CAS号87417-00-3 6(S),19-(N,N'-p... | CAS号104973-32-2 6(S),19-(N,N'-p... | CAS号50-14-6 维生素D2 | CAS号87680-65-7 维生素D2 SO2加合物 | CAS号140710-90-3 3-O-叔丁基二甲基甲硅烷基骨化二醇 | CAS号32222-06-3 骨化三醇

维生素 D3置于双氧水体系中,用 Aq. Phosphate Buffer 用作溶剂,化学反应 1.0H,以100%的收率获得骨化二醇
参考文献:灰霉菌过氧化物酶生产25-羟基维生素d的区域选择性羟化反应
标题:灰霉菌过氧化物酶生产25-羟基维生素d的区域选择性羟化反应
摘要:维生素d 3(胆钙化固醇)和维生素d 2(麦角钙化固醇)的单羟基化代谢物(通常称为25-羟基钙化固醇)比维生素d (钙化固醇)更适合于多种疾病和其他应用.这项工作描述了从容易获得的胆钙化醇和麦角钙化醇开始制备25-羟基钙化醇的新型生物技术方法.该方法通过使用灰霉菌真菌的过氧化物酶(来自测序基因组的基因模型cc1G_08427T0 )在温和且环境友好的条件下使这些化合物(在c-25位置)的区域选择性(100%)羟基化,从而催化单氧合反应. H 2 O 2作为唯一的共底物(过氧化酶).胆钙化固醇和麦角钙化固醇的羟基化是真正的过氧化,如通过将h 2 18 O 2中的18 O掺入产品中所证明的.过氧合酶具有与其重组性质相关的其他优势,可在工业宿主中进行酶工程和低成本过表达.因此,过氧合酶是生产维生素d活性代谢产物的有前途的生物催化剂.
Doi:10.1002/cctc.201402795

专利信息

专利号:US-2022267266-A1
优先权日:2019-07-09
标 题 :Improved, cost effective process for synthesis of vitamin d3 and its analogue calcifediol from ergosterol
发明人：DATLA ANUPAMA; NAGRE PRASHANT; TAMORE JAGDISH; PRABHU MANOJKUMAR SADANAND; KADAM SACHIN VASANT
权利人:FERMENTA BIOTECH LTD
摘要:Disclosed herein is an improved and efficient process for synthesis of vitamin D3 and its analogue Calcifediol from Ergosterol. Particularly, the present invention discloses the synthesis of key intermediate 3β-tert-Butyldimethylsilyloxy-22-hydroxy-23,24-bisnorchola-5,7-diene (5), and novel intermediate β-tert-Butyldimethylsilyloxy-22-iodo-23,24-bisnorchola-5,7-diene (9) by a simple and cost effective process. The industrially viable processes for preparation of said intermediate(s) results in providing provitamins with various side chains and the desired products in high yield.

专利号:US-4174345-A
优先权日:1978-08-01
标题:Synthesis of steroids
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:In the synthesis of sterols wherein methoxyethoxymethyl groups in an ether linkage are attached to the nucleus of the sterol to protect the sterol nucleus during other steps of the synthesis and the sterols are thereafter treated to remove the methoxyethoxymethyl groups and set free the hydroxyl groups, the improvement in which the sterols being treated with zinc bromide are held in a methylene chloride solution containing a small amount of an aliphatic alcohol having from 1 to 6 carbon atoms.

专利号:US-4226770-A
优先权日:1978-02-10
标题:Synthesis of steroids
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:The synthesis of 1α,25-dihydroxycholesterol, 1α,25-dihydroxy-7-dehydrocholesterol and 1α,25-dihydroxycholecalciferol and other sterol derivatives from bile acids. Also the synthesis of 3,6-diketo steroids useful in the production of 1α,25-dihydroxycholesterol and other sterols which are biologically active or can be converted to biologically active sterols. The invention involves the sterols so produced and the processes by which they are prepared.

专利号:US-4163744-A
优先权日:1978-02-10
标 题:Synthesis of steroids
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:The synthesis of 1α,25-dihydroxycholesterol, 1α,25-dihydroxy-7-dehydrocholesterol and 1α,25-dihydroxycholecalciferol and other sterol derivatives from bile acids. Also the synthesis of 3,6-diketo steroids useful in the production of 1α,25-dihydroxycholesterol and other sterols which are biologically active or can be converted to biologically active sterols. The invention involves the sterols so produced and the processes by which they are prepared.

专利号:US-9994508-B2
优先权日:2012-12-11
标 题:Versatile and functionalised intermediates for the synthesis of vitamin D and novel vitamin D derivatives
发明人：LOPEZ PEREZ BORJA; SIGUEIRO PONTE RITA; MAESTRO SAAVEDRA MIGUEL A; MOURINO MOSQUERA ANTONIO
权利人:ENDOTHERM GMBH
摘要:Novel intermediates for the complete synthesis of vitamin D are provided that allow a great versatility of functional groups in the final vitamin derivatives. Vitamin derivatives that are epimeric in position 3 and vitamin derivatives with a wide range of functionalities in position 18, including compounds with isotopic labelling are provided.

专利号:US-4217279-A
优先权日:1978-12-18
标 题 :Synthesis of steroids
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:The synthesis of 25-hydroxycholesterol and 1α,25-dihydroxycholesterol in which the sterol nucleus of an ester of hyodeoxycholic acid is stabilized by protection of the 3 and 6α-hydroxyl groups with alkyl groups, alkyl ether groups, preferably with the 3β-methoxyethoxymethyl group or with the heterocyclic 2-tetrahydropyran group, then extending the chain from the carbon at the 24-position to a cyanide group at the 25-position and then subjecting the sterol so formed to a series of reactions by which it is transformed into 1α,25-dihydroxycholesterol or by a modified series of reactions to 25-hydroxycholesterol.