CAS: 1780-27-4; 4,5,6-Trichloropyrimidine

该化合物是一种杂交有机化合物,其特点是在4,5和6个位置用三氯原子取代一个火水环,该化合物一般没有色状,可粉黄固态,由于环的芳香性质而闻名其相对较高的稳定性,在乙酮和氯仿等有机溶剂中溶解,但水溶解度有限.氯原子的存在会增强它的再活动性,使其在各种化学合成中有用,特别是在制药和农用化学品开发中. 4,5,6-三氯胺可参与核循环替代反应,允许引入各种功能组.此外,必须谨慎处理该化合物,因为其潜在的毒性和环境影响.与许多氯化化合物一样,它可能对人类健康和环境造成风险,因此在使用和处置过程中必须采取适当的安全措施.

结构式图片

相似化合物

6554-61-6 1780-40-1 5750-76-5

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

CAS号1193-24-4 4,6-二羟基嘧啶 | CAS号4316-93-2 4,6-二氯-5-硝基嘧啶 | CAS号88982-91-6 4-羟基-5,6-二氯嘧啶 | CAS号63447-41-6 4,6(1H,5H)-Pyri... | CAS号17573-78-3 4,5,6-三氟嘧啶 | CAS号25096-66-6 5-氯-4,6-二氟嘧啶

合成工艺路线路线简述

  • 合成目标产物 4,5,6-Trichloropyrimidine 主要起始原料 4,6-Dihydroxypyrimidine
  • (文献来源)合成步骤主要原料 4,6-Dihydroxypyrimidine
📜4,6-二氯-5-硝基嘧啶置于苯基二氯化磷体系中,用 Various Solvent(S) 用作溶剂,化学反应 5.0H,以82%的收率获得4,5,6-三氯嘧啶
参考文献:A Simple Direct Procedure For The Regiospecific Preparation Of Chloro Aromatic Compounds
标题:A Simple Direct Procedure For The Regiospecific Preparation Of Chloro Aromatic Compounds
摘要:
Doi:10.1021/jo00247A042

专利信息


专利号:US-4500321-A
优先权日:1980-06-04
标 题:Process for the preparation of concentrated fluid dye compositions
发明人:HUGELSHOFER PAUL; BRUTTEL BEAT; PFENNINGER HEINZ; LACROIX ROGER
权利人:CIBA GEIGY CORP
摘要:A process for the preparation of storage-stable concentrated fluid dye compositions of water-soluble dyes, wherein an aqueous solution or suspension of at least one anionic crude dye is passed over a semi-permeable membrane containing ionic groups and having a pore diameter of 1 to 500 ANGSTROM , to remove salts and synthesis by-products of molecular weights less than 500 and to partially remove water, optionally dried, and mixed with a water-miscible organic solvent and, if desired, further additives, before and/or after passage over the semi-permeable membrane. The fluid dye compositions obtained are particularly suitable for use in spray solutions for dyeing leather, as well as for the dying and printing of textile materials, in particular cellulosic fibres.

专利号:CN-116693461-A
优先权日:2023-06-28
标 题:A new synthesis method of 4,6-dichloro-5-methoxypyrimidine

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


参考文献:10.1007/bf00480435
摘要:Feshin VP, Giller SA, Avota LY, Voronkov MG. Study of chloro derivatives of pyridazine and the products of silylation of pyridazine and 6-pyridazone derivatives by cl35 nuclear quadrupole resonance. Chemistry of Heterocyclic Compounds. 1976 Apr;12(4):440–3. doi: 10.1007/bf00480435.
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