专利号:US-6794534-B2 优先权日:2000-06-23 标题:Synthesis of functionalized and unfunctionalized olefins via cross and ring-closing metathesis 发明人:GRUBBS ROBERT H; CHATTERJEE ARNAB K; MORGAN JOHN P; SCHOLL MATTHIAS; CHOI TAE-LIM 权利人:CALIFORNIA INST OF TECHN 摘要:The invention is directed to the cross-metathesis and ring-closing metathesis reactions between geminal disubstituted olefins and terminal olefins, wherein the reaction employs a Ruthenium or Osmium metal carbene complex. Specifically, the invention relates to the synthesis of α-functionalized or unfunctionalized olefins via intermolecular cross-metathesis and intramolecular ring-closing metathesis using a ruthenium alkylidene complex. The catalysts preferably used in the invention are of the general formula n wherein: n M is ruthenium or osmium; n X and X 1 are each independently an anionic ligand; n L is a neutral electron donor ligand; and, n R, R 1 R 6 , R 7 , R 8 , and R 9 are each independently hydrogen or a substituent selected from the group consisting of C 1 -C 20 alkyl, C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, aryl, C 1 -C 20 carboxylate, C 1 -C 20 alkoxy, C 2 -C 20 alkenyloxy, C 2 -C 20 alkynyloxy, aryloxy, C 2 -C 20 alkoxycarbonyl, C 1 -C 20 alkylthio, C 1 -C 20 alkylsulfonyl and C 1 -C 20 alkylsulfinyl.
专利号:US-6765114-B1 优先权日:1998-12-29 标题 :Process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid 发明人:GIZUR TIBOR; LENGYEL ZOLTANNE; SZALAI KRISZTINA 权利人:RICHTER GEDEON VEGYESZET 摘要:The invention relates to a new process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid of formula (I) via the new intermedier 1-(nitromethyl)cyclohexyl-acetic acid derivative of formula (II), wherein R represents hydrogen, benzyl group, diphenylmethyl group or C 1 -C 4 alkyl or alkoxy aromatic ring substituted derivatives thereof.
专利号:WO-0039074-A1 优先权日:1998-12-29 标题 :Process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid
专利号:SK-9372001-A3 优先权日:1998-12-29 标题:Process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid
专利号:ES-2207979-T3 优先权日:1998-12-29 标 题:PROCESS FOR SYNTHESIS OF ACID 1- (AMINO-METIL) -CICLOHEXIL-ACETIC.
专利号:US-2002137978-A1 优先权日:2000-06-23 标题:Synthesis of functionalized and unfunctionalized olefins via cross and ring-closing Metathesis