CAS: 1468-83-3; 3-Acetylthiophene

相似化合物

14861-60-0 51179-52-3 222609-67-8

上下游产品

3-thiophene carboxylic acid chloride dimethylcadmium 3-acetyl-2,5-dichlorothiophene methyllithium 1-[3]thienyl-ethanone-(2,4-dinitro-phenylhydrazone) (thienyl-3) glyoxal 2-(thiophene-3-yl) acetamide 1-(2-bromo-thien-4-yl)ethanone

1-(噻吩-3-基)乙醇置于亚硝酸特丁酯,氧气,3,6-二-2-吡啶基-1,2,4,5-四嗪,溶剂黄146体系中,用 乙腈 用作溶剂,化学反应 4.5H,以71%的收率获得3-乙酰基噻吩
参考文献:Metal Free Visible Light Driven Oxidation Of Alcohols To Carbonyl Derivatives Using 3,6-Di(Pyridin-2-yl)-1,2,4,5-Tetrazine (Pytz) As Catalyst
标题:Metal Free Visible Light Driven Oxidation Of Alcohols To Carbonyl Derivatives Using 3,6-Di(Pyridin-2-yl)-1,2,4,5-Tetrazine (Pytz) As Catalyst
摘要:在可见光照射下,在室温下使用二(吡啶-2-基)-1,2,4,5-四唑(pytz)作为催化剂,成功实现了醇类向相应酮类的金属无催化转化,且收率较高.
Doi:10.1039/c5Ra18151H

专利信息

专利号:US-5059709-A
优先权日:1990-11-13
标题 :Process for the synthesis of α-[(dialkylamino)substituted-methylene]-β-oxo-(substituted)propanentriles
发明人：DUSZA JOHN P; CHURCH ROBERT F
权利人:AMERICAN CYANAMID CO
摘要:A novel process for producing α-[(dialkylamino) substituted-methylene]β-oxo-(substituted) propanenitriles of the formula: ##STR1## where R, R 1 and R 2 are defined in the specification by reacting a substituted isoxazole with a diaklylamide dimethylacetal is provided.

专利号:US-6005103-A
优先权日:1993-11-19
标题 :Pyrone derivatives as protease inhibitors and antiviral agents
发明人：DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
权利人:WARNER LAMBERT CO
摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.

专利号:US-4471139-A
优先权日:1982-05-24
标题 :Processes for making 3-methylthiophene-2-carboxaldehyde and intermediates therefor
发明人：ANDREWS GLENN C
权利人:PFIZER
摘要:Processes for preparing isomerically pure 3-methylthiophene-2-carboxaldehyde, an intermediate for synthesis of anthelmintic agents, by reaction of mercaptoacetaldehyde or the dimer, or a polymer thereof, or a dialkylacetal thereof in the presence of a base with (1) methyl vinyl ketone or an alpha- or beta-oxidized derivative of methyl vinyl ketone to form a 3-oxobutylmercaptoacetaldehyde or dialkyl acetal thereof, or an alpha- or beta-substituted derivative thereof which is then converted to 3-methylthiophene-2-carboxaldehyde via appropriate steps including, if necessary, treatment with acid, followed, if necessary, by enamine catalyzed cyclization and, in the case of using methyl vinyl ketone as reactant, a dehydrogenation step; or (2) 3-butyn-2-one to produce a mixture of isomeric 3-oxobut-1-enylmercaptoacetaldehyde or dialkyl acetals thereof which is cyclized to 3-methylthiophene-2-carboxaldehyde. n A further aspect of this invention is an improved process for making dialkyl acetals of 2-mercaptoacetaldehyde which comprises reacting an alkyl vinyl ether with sulfur chloride to produce a bis(2-chloro-2-alkoxy ethyl)disulfide which is then treated with an alcohol to afford a bis(2,2-dialkoxyethyl)disulfide which is reduced under alkaline conditions to 2-mercaptoethyl acetaldehyde alkali metal salt which can be alkylated to a thioether, a valuable intermediate.

专利号:US-4775757-A
优先权日:1986-09-22
标题:Thienopyridines useful as cardiovascular agents
发明人：KANOJIA RAMESH M; MCNALLY JAMES J; PRESS JEFFERY B
权利人:ORTHO PHARMA CORP
摘要:The synthesis of thienopyridine derivatives is described. The novel thienopyridine derivatives are cardiotonic agents and renal vasodilating agents. The compounds are useful as cardiovascular agents.

专利号:US-4476312-A
优先权日:1982-05-24
标 题:Processes for making 3-methylthiophene-2-carboxaldehyde and intermediates therefor
发明人：ANDREWS GLENN C
权利人:PFIZER
摘要:Processes for preparing isometrically pure 3-methylthiophene-2-carboxaldehyde, an intermediate for synthesis of anthelmintic agents, by reaction of mercaptoacetaldehyde or the dimer, or a polymer thereof, or a dialkylacetal thereof in the presence of a base with (1) methyl vinyl ketone or an alpha- or beta- oxidized derivative of methyl vinyl ketone to form a 3-oxobutylmercaptoacetaldehyde or dialkyl acetal thereof, or an alpha- or beta-substituted derivative thereof which is then converted to 3-methylthiophene-2-carboxaldehyde via appropriate steps including, if necessary, treatment with acid, followed, if necessary, by enamine catalyzed cyclization and, in the case of using methyl vinyl ketone as reactant, a dehydrogenation step; or (2) 3-butyn-2-one to produce a mixture of isomeric 3-oxobut-1-enylmercaptoacetaldehyde or dialkyl acetals thereof which is cyclized to 3-methylthiophene-2-carboxaldehyde. n A further aspect of this invention is an improved process for making dialkyl acetals of 2-mercaptoacetaldehyde which comprises reacting an alkyl vinyl ether with sulfur chloride to produce a bis(2-chloro-2-alkoxy ethyl)disulfide which is then treated with an alcohol to afford a bis(2,2-dialkoxyethyl)disulfide which is reduced under alkaline conditions to 2-mercaptoethyl acetaldehyde alkali metal salt which can be alkylated to a thioether, a valuable intermediate.

专利号:EP-0729465-B1
优先权日:1993-11-19
标 题:Pyrone derivatives as protease inhibitors and antiviral agents
发明人：DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
权利人:PARKE DAVIS & CO
摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.