专利号:US-10174008-B2 优先权日:2014-12-03 标题:Synthesis of cyclopropyl indoles and cyclohepta[B]indoles, pharmaceutical compositions containing them and method of using them 发明人:TANG WEIPING; LI XIAOXUN 权利人:WISCONSIN ALUMNI RES FOUND 摘要:Methods of making indole analogs using a rhodium-containing catalyst are described, along with methods of using the compounds to treat hyperglycemic, hyperlipidemic, or autoimmune disorders in mammals, and corresponding pharmaceutical compositions. Disclosed herein is a method of making indoles. The method comprises contacting a reactant of formula I wherein E is a protecting group, —SO2-Aryl, or —SO2-substituted-Aryl; and R and R2 are independently selected from the group consisting of hydrogen, halo, C1-C12-alkyl and aryl; with a rhodium(1)-containing catalyst.
专利号:US-2024067779-A1 优先权日:2021-03-01 标题:Metallopolymers and iclick synthesis thereof 发明人:BETO CHRISTOPHER; SCHANZE KIRK S; VEIGE ADAM S; YANG YAJING 权利人:UNIV FLORIDA; UNIV OF TEXAS SAN ANTONIO 摘要:Provided herein are various metallopolymers and methods of making the same.
专利号:US-9272260-B2 优先权日:2009-08-14 标 题 :Methods of synthesis and purification by use of a solid support 发明人:HAMMOND GERALD B; XU BO 权利人:HAMMOND GERALD B; XU BO; UNIV LOUISVILLE RES FOUND 摘要:Disclosed herein are novel methods of using polymeric adsorbent resin for chemical synthesis and the purification of product therefrom. Also disclosed herein is a novel method of using silica gel for the combination of chemical reaction and chromatography into a single step. The methods disclosed herein increase the efficiency of chemical synthesis processes. Accordingly, the utility of the methods disclosed herein includes the ability to automate chemical synthesis and purification of the resulting products.
专利号:US-4387208-A 优先权日:1981-12-21 标 题:Phosphorous containing polymers as carriers for transition metals 发明人:ALLCOCK HARRY R; FULLER TIMOTHY J; EVANS THOMAS L 权利人:US NAVY 摘要:Synthesis of new (lithiophenoxy)phosphazene high polymers is described whin polymers such as poly(dichlorophosphazene) are used as the starting material to prepare poly(organophosphazenes) by reaction thereof with sodium para-bromophenoxide. Poly(organophophazenes) thus obtained are used in a metal-halogen exchange reaction with n-butyllithium. The lithio derivatives thus obtained are used as reactive intermediates for the synthesis of polymers of formulas [NP(OC 6 H 4 X-p) x (OC 6 H 4 Br)y] n and [NP(OC 6 H 4 Li-p) x (OPh) y ] n , where X is PPh 2 , PPh 2 C 4 H 9 + Br - , SnPh 3 , AuPPh 3 , or COOH.
专利号:CN-114874141-A 优先权日:2022-06-02 标题:Synthesis of phenanthrene compounds by ring-opening cyclization of alkenyl benzotriazole under visible light catalysis
专利号:US-10494392-B2 优先权日:2017-04-17 标题 :Method of treating cancer with a two-component anti-cancer composition 发明人:ISAB ANVARHUSEIN A; ALTAF MUHAMMAD; SELIMAN ADAM AHMED ABDALLAH 权利人:UNIV KING FAHD PET & MINERALS 摘要:Gold(I) complexes and gold(I) dithiocarbamate polymers as anticancer therapeutics. The Au(I) ion within the gold(I) complexes is coordinated to two phosphine ligands. The repeating unit formed by Au(I) ion coordinating to dithiocarbamate ligands are connected by Au(I)—Au(I) interactions within the gold(I) dithiocarbamate polymers. Also disclosed are methods of synthesis, pharmaceutical compositions incorporating the gold(I) complexes, pharmaceutical compositions incorporating the gold(I) dithiocarbamate polymers, and methods of treating cancer.
参考文献:10.1007/bf02910903 摘要:Mingos DMP, Powell HR, Stolberg TL. Synthesis and structural characterization of the tetrahedral cluster [Au4(PPh3)4(μ2-SnCl3)2]. Transition Metal Chemistry. 1992 Aug;17(4):334–7. doi: 10.1007/bf02910903. 参考文献:10.1007/bf00905829 摘要:Nesmeyanov AN, Grandberg KI, Baukova TV, Kosina AN, Perevalova ÉG. [(Tricarbonylmanganese)cylclopentadienyl] (triphenylphosphine)gold. Russian Chemical Bulletin. 1969 Sep;18(9):1879–81. doi: 10.1007/bf00905829. 参考文献:10.1007/bf00905828 摘要:Nesmeyanov AN, Perevalova ÉG, Lemenovskii DA, Kosina AN, Grandberg KI. Feerocenyl(triphenylphosphine)gold. Russian Chemical Bulletin. 1969 Sep;18(9):1876–8. doi: 10.1007/bf00905828.