专利号:WO-2023118363-A1 优先权日:2021-12-22 标题:Method for the synthesis of a carbonyl-functionalised adduct 发明人:GODEHARD SIMON P; PELZER ALEXANDER 权利人:BRAIN Biotech AG 摘要:The invention relates to a method for the synthesis of a carbonyl-functionalised adduct.
专利号:US-2024209018-A1 优先权日:2021-03-22 标题:Universal linker reagents for dna synthesis 发明人:REED MICHAEL W; WU CHENG-HSIEN; COOPER JOHN; DEMPCY ROBERT O 权利人:GENSCRIPT USA INC; CUSTOMARRAY INC 摘要:Provided herein are methods and compositions for oligonucleotide synthesis utilizing universal linker phosphoramidites. Methods and reagents are described with DNA synthesis using controlled pore glass (CPG) solid supports, and on platinum coated electrodes for electrochemical DNA synthesis. The universal linkers can be used as spacers in single-column PCR primer synthesis to generate 2 strands with free 3′-hydroxy termini after cleavage. The methods and compositions utilize a solid support system for synthesis of oligonucleotides, wherein the support has platinum electrodes and a universal linker, optionally wherein the platinum electrode is coated with an amine. The methods and compositions further describe use of universal linker phosphoramidites and the platinum electrode is coated with a monosaccharide, or a disaccharide.
专利号:US-2024199566-A1 优先权日:2022-11-16 标题:Catalytic synthesis of delta-valerolactone (dvl) from furfural-derived 2-hydroxytetrahydropyran (hthp) 发明人:HUBER GEORGE; DASTIDAR RAKA; JOHNSTONE SAM; MCCLELLAND DANIEL 权利人:WISCONSIN ALUMNI RES FOUND 摘要:A method to make delta-valerolactone (“DVLâ€?) by dehydrogenating 2-hydroxytetrahydropyran (“HTHPâ€?). The HTHP is contacted with a supported-metal catalyst for a time, at a temperature, and at a pressure wherein at least a portion of the HTHP is converted to DVL via dehydrogenation of the HTHP. The HTHP may be derived from biomass. Thus, the method yields DVL without requiring a petroleum-based feedstock.
专利号:US-2023278976-A1 优先权日:2021-07-05 标题:Synthesis Of Beta-Glycolipid Compounds 发明人:BOXLEY CHETT; STOLLEY RYAN; BRUGGEMAN ROBERT 权利人:GLYCOSURF INC 摘要:Methods of forming a glycolipid are disclosed. A method may include glycosylating a sugar with a beta-hydroxyester using BF3-L as a glycosylation promoter. L may include one or more of Diethylether, Tetrahydrofurn, Dimethyle Sulfide, or combinations thereof. The beta-hydroxyester may include a carbon length ranging from C2 to C24. The sugar may be a protected sugar that includes peracetylated-rhamnose, peracetylated-xylose, peracetylated-glucose, peracetylated-galactose or combinations thereof. The beta-hydroxyester and sugar may be combined in a reaction vessel to form a mixture. A solvent may be added to the mixture to substantially dissolve the mixture. The glycosylation promoter may be added to the solution such that the solution is maintained withing a desired temperature range.
专利号:US-10745675-B2 优先权日:2017-05-02 标题:Modified enzymes for producing increased isomelezitose 发明人:COTE GREGORY L; SKORY CHRISTOPHER D 权利人:THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE 摘要:Provided herein are compositions and methods for the synthesis of the trisaccharide, isomelezitose, using genetically modified glucansucrase enzymes from representative microorganisms, including lactic acid bacteria such as Leuconostoc mesenteroides . Various modified enzymes are detailed, increasing isomelezitose yields and provide the foundation for large-scale production of isomelezitose for food, industrial and biomedical applications.
专利号:US-11473116-B2 优先权日:2018-02-23 标题 :Synthesis of glucan comprising alpha-1,3 glycosidic linkages with phosphorylase enzymes 发明人:YU ZHEYONG; KRALJ SLAVKO; ZHANG ZHENGHONG; HOWE LAURIE A 权利人:NUTRITION & BIOSCIENCES USA 4 INC 摘要:Reaction compositions are disclosed herein comprising at least water, beta-glucose -1-phosphate (beta-G1P), an acceptor molecule, and an alpha-1,3-glucan phosphorylase enzyme. These reactions can synthesize oligosaccharides and polysaccharides with alpha-1,3 glycosidic linkages. Further disclosed are alpha-1,3-glucan phosphorylase enzymes and methods of use thereof.
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