CAS: 1219080-61-1; (1H-Imidazol-2-yl)Boronic Acid
该化合物是一种有机有机体化合物,其特征是存在一个imidazole环和一个boron酸功能组,该化合物一般显示白到白的晶状表面,在水和酒精等极溶剂中溶解,可溶于水和酒精,这可归因于二氧化酸合金的存在.二硝二氮环有助于其潜在的生物活动,使其对药用化学,特别是药品的开发感兴趣.一硝二氮二氮酸可参与各种化学反应,包括铃木合金,这是在有机合成中形成碳联结的一种广泛使用的方法.此外,二醇的碳酸组可形成可逆的复合体,有助于感化应用.其反应性和功能性使它成为更复杂的分子合成的一个有价值的建筑块,特别是在有机化学和药用化学领域.在处理和储存方面,应参考安全数据,以便与所有化学物质一起处理和储存.
- 英文名称(1H-Imidazol-2-yl)Boronic Acid
- 中文名称1H-咪唑-2-基硼酸
- IUPAC名称(1H-imidazol-2-yl)boronic acid
- 其它别名1H-Imidazol-2-Ylboronic Acid; Imidazole-2-Boronic Acid; (1H-Imidazol-2-yl)Boronic Acid; Boronic Acid, B-1H-Imidazol-2-Yl-; 1H-Imidazol-2-Ylboronic Acid, Hcl; C3H5Bn2O2; 1H-Imidazole-2-Yl-Boronic Acid; (1H-Imidazol-2-yl)Boronic; 1H-Imidaz
- CAS编号1219080-61-1
- MFCD编号:MFCD09038902
- 分子式:C3H5BN2O2分子量:111.9
- 产品CID: 306478
- 产品分类医药中间体
物理性质
MSDS等安全信息
合成工艺路线路线简述
专利信息
专利号:US-2023212216-A1
优先权日:2019-12-20
标 题:Synthesis of lactone derivatives and their use in the modification of proteins
发明人：MORRIS ALEXANDER REDFERN; SUTOV GRIGORIJ; BRUNE KARL DIETRICH
权利人:GENIE BIOTECH UK LTD
摘要:Site-specific modifications of proteins are desirable in biotechnological applications such as biopharmaceuticals, immunotherapy, vaccines, and are useful in chemical biology. Gluconoylation is a non-enzymatic, covalent, post-translational modification commonly observed on N-terminal His-Tags bearing proteins. We synthesized glucono-1,5-lactone derivatives, including azido variants for selective acylation. High yield acylation is achieved by simply mixing derivatives with target protein amidst diverse conditions of temperatures, aqueous buffers, excipients, or complex cell lysate.
专利号:EP-4076533-A1
优先权日:2019-12-20
标 题:Synthesis of lactone derivatives and their use in the modification of proteins
