CAS: 119520-05-7; Zilpaterol Hydrochloride

专利信息

专利号:US-8629134-B2
优先权日:2007-02-01
标题:Enantioselective synthesis of 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one and zilpaterol
发明人：ALMENA-PEREA JUAN JOSE; BRINK MONIKA; GEIBETA GERHARD; KADYROV RENAT; MEYER THORSTEN
权利人:ALMENA-PEREA JUAN JOSE; BRINK MONIKA; GEIBETA GERHARD; KADYROV RENAT; MEYER THORSTEN; INTERVET INT BV
摘要:This invention relates to a process for the hydrogenation of a ketooxime to selectively form an aminoalcohol stereoisomer, and, in particular, to a process for the hydrogenation of 4,5-dihydro-imidazo[4,5,1-jk][1]benzazepin-2,6,7[1H]-trione-6-oxime or a salt thereof to selectively form a stereoisomer of 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one or a salt thereof. This invention also relates to the use of the 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one hydrogenation product or a salt thereof to selectively make a stereoisomer of zilpaterol or a salt thereof, as well as the use of such a zilpaterol stereoisomer or salt in methods of treatment and medicaments for animals.

专利号:EP-2109614-B1
优先权日:2007-02-01
标题:Enantioselective synthesis of 6-amino-7-hydroxy-4, 5, 6, 7-tetrahydro-imidazo [4, 5, 1-jk][1]-benzazepin-2 [1h]-one and zilpaterol

专利号:WO-2008092924-A1
优先权日:2007-02-01
标题:Enantioselective synthesis of 6-amino-7-hydroxy-4, 5, 6, 7-tetrahydro-imidazo [4, 5, 1-jk] [1] -benzazepin-2 [1h] -one and zilpaterol

专利号:US-2010173892-A1
优先权日:2007-02-01
标题:Enantioselective synthesis of 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-JK][1]-benzazepin-2[1H]-one and zilpaterol