CAS: 10172-89-1; N-Acetyl-D-Phenylalanine

相似化合物

2018-61-3 2901-75-9 2361-96-8

上下游产品

(R,S)-N-acetyl phenylalanine (1S)-endo-fenchylamine (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol D-(R)-phenylalanineD-(R)-phenylalanine (R)-ethyl N-acetylphenylalanine (2R,3R)-2-((R)-2-Acetylamino-3-phenyl-propionylamino)-3-hydroxy-butyric acid benzyl ester 4-(B°C-tyrosylamino)-1-(N-acetyl-D-phenylalanyl)piperidine

D-苯丙氨酸置于sodium Hydroxide,乙酸酐体系中,用 水 用作溶剂,化学反应生成N-乙酰-D-苯丙氨酸
参考文献:Optical Resolution Of Alkyl Esters Of Dl-Phenylalanine
标题:Optical Resolution Of Alkyl Esters Of Dl-Phenylalanine
摘要:用n-酰基-D-苯丙氨酸处理dl-苯丙氨酯,形成相应的l-苯丙氨酯和n-酰基-D-苯丙氨酸的不溶性盐.通过在dl-苯丙氨酯或l-苯丙氨酸的烷基酯的存在下重新结晶纯化盐.分离,纯化的盐被分解以获得所需的l-苯丙氨酯,这是制备人工甜味剂的重要原料.

专利信息

专利号:US-7317129-B2
优先权日:2002-06-07
标 题:Chemical synthesis of reagents for peptide coupling
发明人：RAINES RONALD T; KIESSLING LAURA L; NILSSON BRADLEY L; HE YI; SOELLNER MATTHEW B; HINKLIN RONALD J
权利人:WISCONSIN ALUMNI RES FOUND
摘要:The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly, for peptide ligation. The invention provides phosphine-borane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.

专利号:US-4985567-A
优先权日:1988-03-07
标题:Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds
发明人：ACHIWA KAZUO; TAKEDA HIDEO
权利人:KAZUO ACHIWA; FUJI YAKUHIN KOGYO KK
摘要:New chiral phosphinopyrrolidine compounds of the general formula: ##STR1## wherein R 1 is hydrogen or --COA 1 , --COOA 2 , --CONHA 3 , --SO 2 A 4 or --PO(A 5 ) 2 , A 1 , A 2 , A 3 , A 4 and A 5 each represents independently alkyl or aryl, R 2 is phenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, and R 3 is phenyl, lower-alkylphenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, with the proviso that R 2 and R 3 may not simultaneously by phenyl, p-di(lower-alkyl)-aminophenyl or p-lower-alkoxyphenyl, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.

专利号:US-4891442-A
优先权日:1987-03-09
标 题 :Process for synthesis of β-phenylalanine
发明人：LIN JIANG-JEN; KNIFTON JOHN F
权利人:TEXACO INC
摘要:N-acetyl-β-phenylalanine is synthesized by reacting phenylacetaldehyde, acetamide and synthesis gas with a catalyst comprising a cobalt-containing compound in conjunction with a cocatalyst that may be either a Group VB or VIB containing ligand, or a rhodium compound optionally bonded to one or more Group VB or VIB donor ligands, at a temperature of at least 50° C. and a pressure of at least 500 psi.

专利号:US-6380416-B2
优先权日:1997-06-13
标题:Asymmetric synthesis catalyzed by transition metal complexes with rigid chiral ligands
发明人：ZHANG XUMU
权利人:PENN STATE RES FOUND
摘要:This invention is to develop novel transition metal catalysts for the practical synthesis of important chiral molecules. The invention emphasizes asymmetric catalysis based on chiral bidentate phosphine ligands with cyclic ring structures which could be used to restrict conformational flexibility of the ligands and thus the efficiency of chiral transfer can be enhanced through the ligand rigidity.

专利号:US-7230135-B2
优先权日:2000-12-13
标 题 :Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts
发明人：HOGE II GARRETT STEWART; GOEL OM PRAKASH
权利人:WARNER LAMBERT CO
摘要:P-chiral bisphospholane ligands and methods for their preparation are described. Use of metal/P-chiral bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.

专利号:US-10947231-B2
优先权日:2009-05-27
标题:Processes for the preparation of substituted tetrahydro beta-carbolines
发明人：HWANG PETER SEONGWOO; MOON YOUNG-CHOON; TAMIL ARASU; QI HONGYAN; ALMSTEAD NEIL
权利人:PTC THERAPEUTICS INC
摘要:Provided herein are improved processes for the synthesis of substituted tetrahydro beta-carboline derivatives. In particular, provided herein are improved processes useful for the preparation of (S)-4-chlorophenyl 6-chloro-1-(4-methoxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate. Formula (I):