CAS: 95-46-5; 2-Bromotoluene

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CAS号103-73-1 苯乙醚 | CAS号2093-46-1 2-Methylbenzene... | CAS号333-27-7 三氟甲烷磺酸甲酯 | CAS号583-53-9 1,2-二溴苯 | CAS号108-88-3 甲苯 | CAS号615-37-2 2-碘甲苯 | CAS号124-38-9 二氧化碳 | CAS号61563-25-5 1,2-二溴-3-甲基苯 | CAS号3433-80-5 邻溴溴苄 | CAS号884010-16-6 2-溴苯硼酸新戊二醇酯 | CAS号1075-28-1 1-溴-2-(3-溴丙基)苯 | CAS号1074-92-6 2-叔丁基甲苯 | CAS号104847-07-6 N-叔丁基-2-甲基苯甲酰胺 | CAS号104750-61-0 3-(邻甲苯基)丙酸乙酯 | CAS号41064-50-0 (4-chlorophenyl... | CAS号527-85-5 2-甲基苯甲酰胺 | CAS号5931-53-3 二苯基(o-甲苯基)膦 | CAS号5748-43-6 2’-甲基联苯-4-甲酸 | CAS号52711-30-5 1-溴-2-(甲氧基甲基)苯 | CAS号39512-51-1 1-(2-甲基苯基)哌嗪

邻溴三氟甲苯置于三乙基硅烷,C14H12N2(2+)*2C24Bf20(1-)体系中,化学反应 4.0H,以88%的收率获得产物2-溴甲苯
参考文献:用于无金属加氢脱氟的双吡啶鎓和菲咯啉双阳离子:独特的碳基反应性
标题:用于无金属加氢脱氟的双吡啶鎓和菲咯啉双阳离子:独特的碳基反应性
摘要:报道了衍生自联吡啶鎓和菲咯啉鎓的新型路易斯酸的开发.氢化物离子亲和力 (Hia) 值的计算表明邻位和对位的碳基路易斯酸度较高.这部分源于芳族骨架上的广泛 Lumo 离域.物种 [c 10 H 6 R 2 N 2 Ch 2 Ch 2] 2+ (R=h [1 A] 2+,Me [1 F] 2+,T Bu [1 G] 2+) 和 [c 12 H 4 R 4N 2 Ch 2 Ch 2] 2+(r=h [2 A] 2+,Me [2 B] 2+)被制备并评估用于引发加氢脱氟(hdf)催化.化合物[2 A] 2+被证明对于通过路易斯酸介导的从硅烷中提取氢化物反应生成具有催化活性的甲硅烷阳离子非常有效.这使得在温和条件下能够形成一系列芳基和烷基取代的 Sp 3 (Cf) 键的 Hdf .该方案还适用于实现顺式-2,4,6-(Cf 3) 3 C 6 H 9 的氘代脱氟. 显示出作为氢化物受体,分离中性物质
DOI:10.1002/chem.202101534

专利信息

专利号:US-11873305-B2
优先权日:2020-06-30
标题 :Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds
发明人：ZHANG HAIMING; XU JIE; WUITSCHIK GEORG; ANGELAUD REMY; HEROLD SEBASTIAN; STUTZ ALFRED; BRUETSCH TOBIAS; BURKHARD JOHANNES
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are processes for the preparation of indolyl intermediates using Wenker Synthesis for the total synthesis of SERD compounds useful in the treatment of cancer.

专利号:US-5817751-A
优先权日:1994-06-23
标 题 :Method for synthesis of diketopiperazine and diketomorpholine derivatives
发明人：SZARDENINGS ANNA KATRIN; CAMPBELL DAVID
权利人:AFFYMAX TECH NV
摘要:The present invention relates to the areas of organic and medicinal chemistry. More specifically, the present invention is concerned with combinatorial and solid phase methods for the synthesis of diverse diketopiperazine derivatives, and the use of such methods to create libraries of diverse diketopiperazine derivatives. The present invention has application in the areas of chemical synthesis, the screening for new diketopiperazine derivatives having beneficial medical properties and the use of such screening to provide compositions and methods including diketopiperazine derivatives for treating disease.

专利号:US-6376649-B1
优先权日:1998-12-18
标题 :Methods for the synthesis of α- hydroxy-β-amino acid and amide derivatives
发明人：SEMPLE JOSEPH E; LEVY ODILE E
权利人:CORVAS INT INC
摘要:Methods for the synthesis of alpha-hydroxy-beta-amino acid and amide derivatives and alpha-ketoamide derivatives and novel derivatives made by these methods are provided. These methods involve reacting a N-terminally blocked (protected) aminoaldehyde with an isonitrile and a carboxylic acid to give an amino-alpha-acyloxy carboxamide. The acyloxy group may be removed to give the derivative. Alternatively the protecting group is removed and acyl shift occurs to give the derivative. These derivatives are useful in the synthesis of compounds such as peptidyl alpha-ketoamides and alpha-hydroxy-beta-carboxylic acid and amide derivatives. Certain of these compounds have been reported to have activity as inhibitors of proteases, such as serine proteases and cysteine proteases.

专利号:US-7102023-B2
优先权日:1999-11-24
标 题:Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries
发明人：BUCHWALD STEPHEN L; PLANTE OBADIAH J; SEEBERGER PETER H
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention relates to use of said protecting groups in an orthogonal protecting group strategy for the synthesis of complex molecules that comprise a number of suitable functional groups. Another aspect of the present invention relates to saccharides bearing various arrays of protecting groups of the present invention. Another aspect of the present invention relates to a method of synthesizing an oligosaccharide or glycoconjugate, comprising the steps of: using a saccharide bearing at least one protecting group of the present invention to glycosylate a second molecule to give a product comprising said saccharide; and removing a protecting group of the present invention from said product.

专利号:US-6133409-A
优先权日:1996-12-19
标 题:Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds
发明人：SALVINO JOSEPH M; MORTON GEORGE C; MASON HELEN J; LABAUDINIERE RICHARD F
权利人:AVENTIS PHARM PROD INC
摘要:This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and alpha , beta -unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.

专利号:WO-2020185105-A1
优先权日:2019-03-14
标题:Improved method for the synthesis of pyrrolo[3,2-b]pyrroles
发明人：GRYKO DANIEL; TASIOR MARIUSZ; KOSZARNA BEATA; YOUNG DAVID C
权利人:INST CHEMII ORGANICZNEJ PAN
摘要:An improved method for the synthesis of pyrrolo[3,2- b ] pyrroles using iron (III) salts as a catalyst is disclosed.