CAS: 930303-26-7; (3-Methylpyridin-2-yl)Boronic Acid

该化合物是一种多用途的boronic 酸衍生物,通常在铃木-宫浦交叉相交反应中用作关键中间体.它的片片在三方形中被一个甲基组替代,增强了其在催化变异变的稳定性和再活动性,使其对建造双子体和异丙醇结构具有价值. 苯丙酸功能允许选择性地与丙烯或乙烯卤化物结合,从而能够有效地合成复杂的有机分子,特别是在制药和农用化学应用中. 这种复合物展示了共同有机溶剂的溶性,便利了其在合成工作流程中的处理. 它的一贯性能和兼容性使得它成为药用化学和材料科学研究的可靠选择.

结构式图片

上下游产品

2-bromo-3-picoline Triisopropyl borate

合成工艺路线路线简述

  • 3430-17-9 = 930303-26-7
    反应条件:1.1 Reagents: Chloro(1-Methylethyl)Magnesium Solvents: Diethyl Ether,Tetrahydrofuran; 0 °C; 3 H,0 °C1.2 Reagents: Triisopropyl Borate; 1 H,Rt1.3 Reagents: Ammonium Chloride Solvents: Water
    标题:Tetrahydroquinoline Compositions As Bet Bromodomain Inhibitors And Their Preparation
    参考文献:United States]

    3430-17-9 = 930303-26-7
    反应条件:1.1 Reagents: Butyllithium Solvents: Diethyl Ether,Hexane; 10 Min,-78 °C; 90 Min,-78 °C1.2 Reagents: Triisopropyl Borate; -78 °C; -78 °C -> Rt; 90 Min,Rt1.3 Reagents: Sodium Hydroxide Solvents: Water; 0 °C1.4 Reagents: Hydrochloric Acid Solvents: Water; Ph 7
    标题:Preparation Of Bi-Aryl Aminotetralines As Crth2 Receptor Antagonists
    参考文献:World Intellectual Property Organization
📜2-溴-3-甲基吡啶,硼酸三异丙酯置于异丙基氯化镁体系中,用 四氢呋喃,乙醚,甲醚 作为反应溶剂,化学反应 4.0H,以92%的收率获得产物3-甲基吡啶-2-硼酸
参考文献: Tetrahydroquinoline Compositions As Bet Bromodomain Inhibitors[fr] Compositions De Tétrahydroquinoline Utilisées Comme Inhibiteurs De Protéines à Bromodomaine Et Domaine Extraterminal (Bet)
标题: Tetrahydroquinoline Compositions As Bet Bromodomain Inhibitors[fr] Compositions De Tétrahydroquinoline Utilisées Comme Inhibiteurs De Protéines à Bromodomaine Et Domaine Extraterminal (Bet)

海关参考信息

专利信息


专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

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