CAS: 91188-13-5; Tert-Butyl Azetidin-3-Ylcarbamate

相似化合物

217806-26-3 218430-15-0 1521828-13-6

📜1-二苯甲基氮杂环丁烷-3-氨基甲酸叔丁酯置于palladium Dihydroxide 盐酸,氢气体系中,用 1,4-二氧六环,甲醇 作为反应溶剂,化学反应生成 3-N-叔丁氧羰基胺基环丁胺
参考文献: Guanidino-Substituted Quinazolinone Compounds As Mc4-R Agonists[fr] Composes De Quinazoline Substitues Par Guanidino Constituant Des Agonistes De Mc4-R
标题: Guanidino-Substituted Quinazolinone Compounds As Mc4-R Agonists[fr] Composes De Quinazoline Substitues Par Guanidino Constituant Des Agonistes De Mc4-R
摘要:提供了一系列含有胍基的小分子化合物,能够作为mc4-R激动剂.当这些化合物被给予受试者时,它们对治疗mc4-R介导的疾病是有用的.这些化合物具有结构ia,Ib和ic,其中变量的值在此定义.

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-9868746-B2
优先权日:2012-02-23
标题:Substituted 5-aminothieno[2,3-C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; MELANCON BRUCE J; TARR JAMES C; SALOVICH JAMES M; POSLUSNEY MICHAEL S
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted 5-aminothieno[2,3-c]pyridazine-6-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 4 (mAChR M 4 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-4870169-A
优先权日:1985-07-17
标 题:Intermediates for beta-lactam antibiotics
发明人：EVANS DAVID A; SJOGREN ERIC B
权利人:HARVARD COLLEGE
摘要:1-Benzyl(or substituted benzyl)-3β-[4(S)-aryloxazolidin-2-one-3-yl]-4β-(2-arylvinyl)azetidin-2-ones are provided via cycloaddition of a 4(S)-aryloxazolidin-2-one-3-ylacetyl halide and an imine formed with a benzylamine and a 3-arylacrolein, e.g. cinnamaldehyde. The azetidinones are useful chiral intermediates in an asymmetric synthesis of 1-carba(1-dethia)-3-hydroxy-3-cephem-4-carboxylic acids and esters and to monocyclic β-lactam antibiotics.

专利号:US-2013060019-A1
优先权日:2011-09-07
标 题 :Compounds for Use in Treating Neurodegenerative Disorders, Synthesis Thereof, and Intermediates Thereto
发明人：BRONK BRIAN SCOTT; AUSTIN WESLEY FRANCIS; CREASER STEFFEN PHILLIP; FULLER NATHAN OLIVER; HUBBS JED LEE; SHEN RUICHAO
权利人:BRONK BRIAN SCOTT; AUSTIN WESLEY FRANCIS; CREASER STEFFEN PHILLIP; FULLER NATHAN OLIVER; HUBBS JED LEE; SHEN RUICHAO; SATORI PHARMACEUTICALS INC
摘要:The present invention provides methods of making a compound of formula II: n n n n n n n n n n or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , and L are as defined and described herein.

专利号:US-4665171-A
优先权日:1985-07-17
标 题:Process and intermediates for β-lactam antibiotics
发明人：EVANS DAVID A; SJOGREN ERIC B
权利人:UNIV HARVARD
摘要:1-Benzyl (or substituted benzyl)-3β-[4(S)-aryloxazolidin-2-one-3-yl]-4β-(2-arylvinyl)azetidin-2-ones are provided via cycloaddition of a 4(S)-aryloxazolidin-2-one-3-ylacetyl halide and an imine formed with a benzylamine and a 3-arylacrolein, e.g. cinnamaldehyde. The azetidinones are useful chiral intermediates in an asymmetric synthesis of 1-carba(1-dethia)-3-hydroxy-3-cephem-4-carboxylic acids and esters and to monocyclic β-lactam antibiotics.

专利号:US-2023090060-A1
优先权日:2020-01-22
标题:Synthesis and application of class of respiratory syncytial virus inhibitors