CAS: 865245-32-5; Tert-Butyl 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)-3,4-Dihydropyridine-1(2H)-Carboxylate

该化合物是化学化合物,其结构复杂,包括二核和含有的混合物,其特点是一个异丁基酯组,这加强了其脂质和稳定性,二氧新郎环的存在表明有机合成和药用化学中的潜在应用,特别是在开发可参与多种化学反应的含有化合物,例如铃木结合;二结构因其生物活动而闻名,通常与钙渠道调节有关;此外,该化合物可能具有有趣的特性,如有机溶剂溶解性以及特定条件下的潜在再活动;其化学文摘社编号865245-325-5,便于识别和检索有关其安全,处理和监管状况的信息;总体而言,该复合物是合成有机化学和药物开发领域的宝贵实体.

结构式图片

相似化合物

731852-88-3 2760488-37-5 3030057-90-7

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MSDS等安全信息

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CAS号25015-63-8 频那醇硼烷 | CAS号171288-01-0 6-trifluorometh... | CAS号85908-96-9 1-B°C-2-哌啶酮 | CAS号154874-91-6 N-叔丁氧羰基天麻

合成工艺路线路线简述

  • 85908-96-9 + 37595-74-7 = 865245-32-5
    反应条件:1.1 Reagents: Potassium Bis(Trimethylsilyl)Amide Solvents: Toluene,Tetrahydrofuran; Rt -> -78 °C1.2 Solvents: Tetrahydrofuran; 1.5 H,-78 °C1.3 Solvents: Tetrahydrofuran; -78 °C; 1 H,-78 °C; 1 H,-78 °C -> Rt2.1 Reagents: Potassium Carbonate Catalysts: Triphenylphosphine,Dichlorobis(Triphenylphosphine)Palladium Solvents: 1,4-Dioxane; 7 H,Rt -> 90 °C
    标题:Preparation And Suzuki-Miyaura Coupling Reactions Of Tetrahydropyridine-2-Boronic Acid Pinacol Esters
    作者:Occhiato,Ernesto G.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(18) 页码:7324-7330]

    171288-01-0 + 73183-34-3 = 865245-32-5
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Triphenylphosphine,Dichlorobis(Triphenylphosphine)Palladium Solvents: 1,4-Dioxane; 7 H,Rt -> 90 °C
    标题:Preparation And Suzuki-Miyaura Coupling Reactions Of Tetrahydropyridine-2-Boronic Acid Pinacol Esters
    作者:Occhiato,Ernesto G.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(18) 页码:7324-7330]

    131667-57-7 + 73183-34-3 = 865245-32-5
    反应条件:1.1 Reagents: Sodium Tert-Butoxide Catalysts: Cuprous Chloride,1,1′-(9,9-Dimethyl-9H-Xanthene-4,5-Diyl)Bis[1,1-Diphenylphosphine] Solvents: Methanol,Toluene; Rt; Rt
    标题:Catalytic Asymmetric Hydrogenation Of (Z)-α-Dehydroamido Boronate Esters: Direct Route To Alkyl-Substituted α-Amidoboronic Esters
    作者:Lou,Yazhou; Et Al
    参考文献:Chemical Science 日期:2020 卷标:11(3) 页码:851-855]

    171288-01-0 + 25015-63-8 = 865245-32-5 + 131667-57-7
    反应条件:1.1 Reagents: Triethylamine Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane; 2 H,Rt -> 50 °C
    标题:Preparation And Suzuki-Miyaura Coupling Reactions Of Tetrahydropyridine-2-Boronic Acid Pinacol Esters
    作者:Occhiato,Ernesto G.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(18) 页码:7324-7330]

    85908-96-9 + 37595-74-7 = 865245-32-5 + 131667-57-7
    反应条件:1.1 Reagents: Potassium Bis(Trimethylsilyl)Amide Solvents: Toluene,Tetrahydrofuran; Rt -> -78 °C1.2 Solvents: Tetrahydrofuran; 1.5 H,-78 °C1.3 Solvents: Tetrahydrofuran; -78 °C; 1 H,-78 °C; 1 H,-78 °C -> Rt2.1 Reagents: Triethylamine Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane; 2 H,Rt -> 50 °C
    标题:Preparation And Suzuki-Miyaura Coupling Reactions Of Tetrahydropyridine-2-Boronic Acid Pinacol Esters
    作者:Occhiato,Ernesto G.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(18) 页码:7324-7330
📜1-Boc-2-哌啶酮置于(1,1'-Bis(Diphenylphosphino)Ferrocene)Palladium(II) Dichloride,双(三甲基硅烷基)氨基钾,三乙胺体系中,用 四氢呋喃,1,4-二氧六环,甲苯 作为反应溶剂,化学反应 5.5H,反应生成 N-叔丁氧羰基-3,4-二氢吡啶-6-硼酸频哪醇酯
参考文献:四氢吡啶-2-硼酸频哪醇酯的制备及suzuki-Miyaura偶联反应
标题:四氢吡啶-2-硼酸频哪醇酯的制备及suzuki-Miyaura偶联反应
摘要:进行了将内酰胺衍生的乙烯基三氟甲磺酸酯和磷酸盐转化为相应的硼酸乙烯基酯的研究.δ-戊内酰胺衍生的乙烯基三氟甲磺酸酯可通过pd与双(频哪醇)二硼烷和频哪醇硼烷,吡咯烷酮和ε-己内酰胺偶合的pd催化成功地转化为1,4,5,6-四氢吡啶-2-硼酸频哪醇酯衍生物衍生物不反应或容易还原.衍生自δ-戊内酰胺的硼酸乙烯基酯是热稳定的化合物,在pd催化下可与结构多样的芳基和杂芳基溴化物和三氟甲磺酸酯,乙烯基碘化物和溴化物以及芳族酰氯有效偶联,从而形成相应的2-取代哌啶达到优异的产量.
DOI:10.1021/jo050995+

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专利信息


专利号:WO-2025125811-A1
优先权日:2023-12-12
标题:Heterocyclic compounds and their use for the treatment of neurological disorders
发明人：PLOWRIGHT ALLEYN THOMAS; PFEIFFER THOMAS; MÄRCHER-RØRSTED EMIL; DUCKWORTH EDWARD JOSEPH
权利人:ONTRACK THERAPEUTICS LTD
摘要:The present invention relates to novel synthetic compounds of Formula (I) and (II) related to naturally occurring flavonoids such as 7,8-dihydroxyflavone (7,8-DHF). The invention further relates to the method of synthesis, the use of these compounds as research tools and their use as pharmaceuticals.

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合成方法参考DOI号:10.1021/jo050995+
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