- ⚠️危险化学品目录(2015年版) 急性毒性-经口,类别1
- 英文名称Tetramethylenedisulfotetramine
- 中文名称毒鼠强
- IUPAC名称2λ6,6λ6-dithia-1,3,5,7-tetrazatricyclo[3.3.1.13,7]decane 2,2,6,6-tetraoxide
- 其它别名2,6-Dithia-1,3,5,7-tetraazaadamantane,2,2,6,6-tetraoxide (6CI,7CI,8CI); 2,6-Dithia-1,3,5,7-tetrazatricyclo[3.3.1.13,7]decane2,2,6,6-tetroxide; Tetramethylenedisulfotetramine; Tetramethylenedisulphotetramine; Tetramine; Tetramine (adamantane derivative)
- CAS编号80-12-6
- MFCD编号:MFCD00221771
- EINECS号:804-552-0
- FDA UNII编号:F6TS3WME05
- 分子式:C4H8N4O4S2分子量:240.26
- 产品CID: 2771976
- 产品分类有机原料 → 有机酸及其衍生物 → 有机硫酸及其衍生物
物理性质
- 熔点242.5°C (粗估)
- 沸点498.1±45.0 °C(预测)
- 闪点2°C
- 密度1.574 (估算)
- pKa:-11.52±0.20(预测)
- 折射率1.6000 (估算)
- 外观形态固体
- 储存条件-20°C
- 产品应用毒鼠强(80-12-6)的用途:是烷基化剂,抗肿瘤药,杀虫剂,化学消毒剂.毒鼠强属惊厥性毒剂,杀鼠毒力大于毒鼠碱.适口性良好,作用非常快,在大剂量时,中毒动物在3分钟内即死亡.中毒症状主要是阵发性抽搐.药理尚不清楚.
- 性质描述毒鼠强(80-12-6)的性质:1.为轻质粉末,纯品呈正方形结晶,无臭无味.2.在255~260°C分解,不溶于水,乙醇,碱和酸,在丙酮,氯仿和冰醋酸中有一定溶解度,溶于二甲亚砜.3.化学性质稳定.毒性:用毒鼠强处理土壤,生长的冷杉4年后结的树籽,仍可毒杀野兔.对大多数哺乳动物有剧毒,对大鼠的急性口服LD50值为0.1~0.3mg/kg.没有选择性毒力,皮肤不吸收,无累积毒性.二次中毒危险性很大.尤其是对植物有内吸作用,可长期滞留在植物体内.
欧盟法规
C&L通报上下游产品
4,10-Dithia-1,3,5,7,9,11-Hexaaza-Tetracyclo[5.5.1.13,11.15,9]Pentadecane 4,4,10,10-Tetraoxide 54475-62-6
2-Thia-1,3,5,7-Tetraaza-Adamantane 2,2-Dioxide 7020-51-1
9-Thia-1,3,6,8-Tetraazatricyclo[4.3.1.1˜3,8˜]Undecane-9,9-Dioxide 37391-75-6📜聚合甲醛置于硫酸,磺酰胺体系中,化学反应生成 毒鼠强
参考文献:Hecht; Henecka,Angewandte Chemie,1949,Vol. 61,P. 365
标题:Hecht; Henecka,Angewandte Chemie,1949,Vol. 61,P. 365
专利信息
专利号:WO-0206209-A1
优先权日:2000-07-19
标 题 :Synthesis method for n1,n3-bis (2.aminoethyl) propane-1,3-diamine, synthesis intermediates, resulting products and use thereof in synthesis of cyclam
发明人:HANDEL HENRI; BERNARD HELENE; ANTOINE MARINE
权利人:UNIV BRETAGNE OCCIDENTALE; HANDEL HENRI; BERNARD HELENE; ANTOINE MARINE
摘要:The invention concerns a method of synthesis of a linear polynitrogen-containing derivative, namely N1,N3-bis (2-aminoethyl) propane-1,3-diamine of general formula (I) using as synthesis intermediates compounds (II) and (III). The invention also concerns the resulting products and their use in the synthesis of cyclic polynitrogen-containing derivatives such as cyclam.
专利号:US-3994972-A
优先权日:1975-06-30
标题:Synthesis of N,N',N',N''-tetra-salicylidene pentaerythrityl tetramine
发明人:SEELY MICHAEL J; PETERSON THOMAS C
权利人:HORIZONS INC
摘要:An improved synthesis of N,N',N',N''-tetra-salicylidene pentaerythrityl tetramine via pentaerythrityl benzene or toluene sulfonates.
专利号:US-2008312430-A1
优先权日:2004-10-20
标题:Method of Preparing or Synthesizing Polyazamacrocycle Derivatives
发明人:CIHELNIK SIMON; DROZ LADISLAV; SRAMEK MARTIN
权利人:THERAPHARM GMBH
摘要:The present invention relates to novel processes for the synthesis of polyazamacrocycle derivatives. Furthermore, the present invention relates to novel polyazamacrocycle derivatives as well as novel intermediates for the synthesis of said polyazamacrocycle derivatives.
专利号:EP-0201761-B1
优先权日:1985-04-30
标题 :Use of basic amides for increasing the porosity in paper or paper-like materials
摘要:1. Use of basic amides from amine mixtures which are obtained as tetramine bottom product in the industrial synthesis of dialkylenetriamines, in particular, dipropylenetriamine and more particularly diethylenetriamine from dihalogenoalkanes and ammonia after the triamine fraction has been distilled off or which are obtained in the industrial synthesis of diethylenetriamine and ethylenediamine from 1,2-dichloroethane and ammonia and long-chain fatty acids or fatty acid mixtures which have a melting point below 30 degrees C, for enhancing the porosity of paper or paperlike materials.
专利号:US-6881847-B2
优先权日:2001-02-01
标题:Process for the synthesis and recovery of nitramines
发明人:HIGHSMITH THOMAS K; HANKS JAMI M; VELARDE STEPHEN P; BOTTARO JEFFREY
权利人:ALLIANT TECHSYSTEMS INC
摘要:A method is provided for the synthesis of nitramines and the recovery of the nitramines from a clathrate.
专利号:US-2002173644-A1
优先权日:1997-03-07
标题:Methods of making cross-bridged macropolycycles
发明人:HILER GEORGE DOUGLAS; PERKINS CHRISTOPHER MARK
摘要:Improved synthesis of a macropolycycle, more particularly, of a cross-bridged tetraazamacrocycle.