CAS: 7619-08-1; 9,12-Octadecadienoic Acid, Ethyl Ester

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    (Z,Z)-9,12-十八烷二烯酸二聚物 Linoleic Acid 60-33-3

    合成工艺路线路线简述

    • 合成目标产物 Ethyl Linoleate 主要起始原料 Ethanol And Linoleic Acid
    • (文献来源)合成步骤主要原料 Ethanol 和 Linoleic Acid
    📜乙醇,(Z,Z)-9,12-十八烷二烯酸二聚物置于盐酸体系中,化学反应生成 亚油酸乙酯
    参考文献:Reformatski,Journal Fur Praktische Chemie (Leipzig 1954),1890,Vol. <2>41,P. 534
    标题:Reformatski,Journal Fur Praktische Chemie (Leipzig 1954),1890,Vol. <2>41,P. 534

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    专利信息


    专利号:US-2005233427-A1
    优先权日:2004-03-31
    标题 :Processes for the production of triglycerides of unsaturated fatty acids in the presence of enzymes
    发明人:SCHOERKEN ULRICH; MEYER CAROLIN; BOTH SABINE; HORLACHER PETER
    权利人:SCHOERKEN ULRICH; MEYER CAROLIN; BOTH SABINE; HORLACHER PETER
    摘要:Processes for the enzyme-catalyzed synthesis of triglycerides containing polyunsaturated fatty acids in which the synthesis is preceded by a pre-hydrolysis in which (a) C 1-4 alkyl esters of polyunsaturated fatty acids are completely or partly hydrolyzed in vacuo with continuous addition of water or are partly hydrolyzed in several stages without vacuum, (b) after the hydrolysis, the water is removed by separation or distillation and (c) the synthesis of the polyunsaturated fatty acids with glycerol in vacuo in the presence of an enzyme to form their triglycerides is carried out under low-water conditions, (d) the enzymes are removed from the triglyceride by separation or filtration and (e) the remaining fatty acids and/or possible residues of C 1-4 alkyl esters are removed from the triglyceride by distillation or refining; the pre-hydrolysis and the subsequent synthesis preferably being carried out as a one-pot process in the same reactor and in the presence of the same enzyme.

    专利号:US-7344868-B2
    优先权日:2003-06-03
    标题:Method for synthesizing ceramide-type compounds
    发明人:LASSALLE LAURENT; YVERGNAUX FLORENT
    权利人:LASSALLE LAURENT; YVERGNAUX FLORENT
    摘要:The invention relates to the fields of fatty substance chemistry, specifically of the ceramide-type compound synthesis. The invention resides substantially in the synthesis of ceramide-type compounds. Specifically, the aim of the invention is a new enzymatic synthesis method, comprising at least one amidification step and one esterification step, achieved through lipases, among fatty acids and/or esters thereof and amino alcohols. The resulting ceramide-type compounds can be used as cosmetic and/or pharmaceutical compositions, in particular as dermatological compositions in conjunction or in admixture with one or more suitable cosmetic and/or pharmaceutical excipients or carriers. The method has an interest particularly in the synthesis of active compounds useful in the fields of cosmetology and/or pharmacology and specifically of dermatology.

    专利号:US-2013303495-A1
    优先权日:2009-12-31
    标题:Emulsion formulations
    发明人:DHINGRA OM; BERNSTEIN JAMES S
    权利人:SOV THERAPEUTICS; DIFFERENTIAL DRUG DEV ASSOCIATES LLC
    摘要:A SEDDS or SMEDDS or SNEDDS formulation for drug delivery of a lipophilic therapeutic agent, providing enhanced modulation of solubility, stability, absorption, metabolism, and/or pharmacokinetic profile of the therapeutic agent by formulation with a lipophilic surfactant, a hydrophilic surfactant, one or more solubilizers and, optionally, digestible oils, resulting in higher bioavailability of the therapeutic agent administered to a subject in need of such therapeutic agent. Also described are pharmaceutical compositions containing the formulations and methods of making and methods of using the formulations and pharmaceutical compositions. Formulations of the disclosure can be constituted to minimize the synthesis of dihydrotestosterone when the therapeutic agent includes testosterone or testosterone esters.

    专利号:CN-104910009-A
    优先权日:2015-06-25
    标题 :A kind of method of ionic liquid catalyzed synthesis of pletil alcohol ester

    专利号:CN-109731607-B
    优先权日:2019-02-18
    标 题:Preparation method of propyl sulfonic group modified SBA-15 and application of propyl sulfonic group modified SBA-15 in synthesis of structured phospholipid

    专利号:US-6949553-B2
    优先权日:2001-06-18
    标题 :Aliphatic compounds, their synthesis method, and utilization of the same
    发明人:TAMAI TADAKAZU; YOSHIKAI KAZUYOSHI; NISHIKAWA MASAZUMI; OGASAWARA KUNIO; MUROTA ITSUKI
    权利人:MARUHA CORP
    摘要:The present invention relates to aliphatic compounds of the formula I, or stereoisomers thereof, or their pharmaceutically acceptable salts: n n nwherein A represents an optionally substituted CH 3 C n H (2n-2m) — (wherein n denotes an integer of 4 to 22, and m represents an unsaturation number which is an integer of 0 to 7), l represents an integer of 0 to 10, s represents 0 or 1, provided that when s is 0, p+q=4 or 5, but when s is 1, p+q=3 or 4, and in each case, either p or q is an integer of 1 or more, R represents an alkyl group having 1 to 10 carbon atoms which may be straight-chain or branched-chain, and R A represents hydrogen or an alkyl group having 1 to 10 carbon atoms which may be straight-chain or branched-chain, and their use in suppression of platelet aggregation, in suppression of inflammation, and in prevention and treatment of circulatory diseases.

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    合成参考文献


    参考文献:10.1021/jf011601s
    摘要:Masuda T, Toi Y, Bando H, Maekawa T, Takeda Y, Yamaguchi H. Structural identification of new curcumin dimers and their contribution to the antioxidant mechanism of curcumin. J Agric Food Chem. 2002 Apr 24;50(9):2524–30. doi: 10.1021/jf011601s.
    参考文献:10.1097/ftd.0b013e318167cfe5
    摘要:Gareri J, Lynn H, Handley M, Rao C, Koren G. Prevalence of fetal ethanol exposure in a regional population-based sample by meconium analysis of fatty acid ethyl esters. Ther Drug Monit. 2008 Apr;30(2):239–45. doi: 10.1097/ftd.0b013e318167cfe5.
    参考文献:10.1002/ptr.1770
    摘要:Kissling J, Ioset JR, Marston A, Hostettmann K. Bio-guided isolation of cholinesterase inhibitors from the bulbs of Crinum x powellii. Phytother Res. 2005 Nov;19(11):984–7. doi: 10.1002/ptr.1770.
    参考文献:10.1007/s00216-010-3474-5
    摘要:Bakdash A, Burger P, Goecke TW, Fasching PA, Reulbach U, Bleich S, Hastedt M, Rothe M, Beckmann MW, Pragst F, Kornhuber J. Quantification of fatty acid ethyl esters (FAEE) and ethyl glucuronide (EtG) in meconium from newborns for detection of alcohol abuse in a maternal health evaluation study. Analytical and Bioanalytical Chemistry. 2010 Feb 10;396(7):2469–77. doi: 10.1007/s00216-010-3474-5.
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