CAS: 7149-42-0; (1-Methylpiperidin-4-yl)Methanamine

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1187582-53-1 144222-22-0 157023-34-2

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CAS号62718-28-9 1-甲基哌啶-4-羧酰胺 | CAS号39546-32-2 4-哌啶甲酰胺 | CAS号20691-92-3 1-甲基哌啶-4-腈 | CAS号1025065-69-3 SGI-1776

📜哌啶-4-甲酰胺置于lithium Aluminium Tetrahydride,Nabh(Oac)2体系中,用 四氢呋喃,乙腈 作为反应溶剂,化学反应生成 (1-甲基-4-哌啶-)甲胺
参考文献:Discovery Of 5-[5-Fluoro-2-Oxo-1,2-Dihydroindol-(3Z)-Ylidenemethyl]-2,4-Dimethyl-1H-Pyrrole-3-Carboxylic Acid (2-Diethylaminoethyl)Amide,A Novel Tyrosine Kinase Inhibitor Targeting Vascular Endothelial And Platelet-Derived Growth Factor Receptor Tyrosine Kinase
标题:Discovery Of 5-[5-Fluoro-2-Oxo-1,2-Dihydroindol-(3Z)-Ylidenemethyl]-2,4-Dimethyl-1H-Pyrrole-3-Carboxylic Acid (2-Diethylaminoethyl)Amide,A Novel Tyrosine Kinase Inhibitor Targeting Vascular Endothelial And Platelet-Derived Growth Factor Receptor Tyrosine Kinase
摘要:To Improve The Antitumor Properties And Optimize The Pharmaceutical Properties Including Solubility And Protein Binding Of Indolin-2-Ones,A Number Of Different Basic And Weakly Basic Analogues Were Designed And Synthesized. 5-[5-Fluoro-2-Oxo-1,2-Dihydroindol-(3Z)-Ylidenemethyl]-2,4-Dimethyl-1H-Pyrrole-3-Carboxylic Acid (2-Diethylaminoethyl)Amide (12B Or Su11248) Has Been Found To Show The Best Overall Profile In Terms Of Potency For The Vegf-R2 And Pdgf-Rbeta Tyrosine Kinase At Biochemical And Cellular Levels,Solubility,Protein Binding,And Bioavailability. 12B Is Currently In Phase I Clinical Trials For The Treatment Of Cancers.
DOI:10.1021/jm0204183

专利信息

专利号:US-6608196-B2
优先权日:2001-05-03
标题 :Process for solid supported synthesis of pyruvate-derived compounds
发明人：WANG BING; JANAGANI SATYANARAYANA; CALLAWAY WYETH B; SESSLER JONATHAN L
权利人:GALILEO PHARMACEUTICALS INC
摘要:Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.

专利号:US-8933227-B2
优先权日:2009-08-14
标题 :Selective synthesis of functionalized pyrimidines
发明人：LINZ GUENTER; KRAEMER GERD; KUSSEROW SABRINA; SCHNAUBELT JUERGEN
权利人:LINZ GUENTER; KRAEMER GERD; KUSSEROW SABRINA; SCHNAUBELT JUERGEN; BOEHRINGER INGELHEIM INT
摘要:The present invention relates to a process for making 2,4-differentiated 5-trifluoromethyl pyrimidines and 2-amino-5-trifluoromethyl-pyrimidine derivatives, which compounds are useful in the preparation of pharmacologically active compounds.

专利号:US-2002048774-A1
优先权日:1996-11-29
标题 :Liquid phase parallel synthesis of chemical libraries

专利号:US-9982006-B2
优先权日:2014-08-21
标题:2′-chloro aminopyrimidinone and pyrimidine dione nucleosides
发明人：CLARKE MICHAEL O'NEIL HANRAHAN; MACKMAN RICHARD L; SIEGEL DUSTIN
权利人:GILEAD SCIENCES INC
摘要:Provided herein are formulations, methods and substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds.

专利号:US-2011190499-A1
优先权日:2009-08-14
标题 :Selective synthesis of functionalized pyrimidines

专利号:US-9828388-B2
优先权日:2014-07-28
标题:Thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-D]pyrimidines useful for treating respiratory syncitial virus infections
发明人：CLARKE MICHAEL O'NEIL HANRAHAN; MACKMAN RICHARD L; SIEGEL DUSTIN
权利人:GILEAD SCIENCES INC
摘要:Provided herein are formulations, methods and substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds.