CAS: 6900-87-4; Hypaconitine
该化合物是一种来自植物基因突变的强力藻类,通常被称为僧侣或狼巴因,其特点是复杂的分子结构,包括多环和氮原子,有助于其药理特性.Hypaconitine因其...
- 英文名称Hypaconitine
- 中文名称次乌头碱
- IUPAC名称(3S,6S,7R,7aR,8R,9R,10S,11S,11aR,13R,14R)-11a-acetoxy-9,11-dihydroxy-6,10,13-trimethoxy-3-(methoxymethyl)-1-methyltetradecahydro-2H-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocin-8-yl benzoate
- 其它别名Hypaconitine(6CI,7CI,8CI); 2H-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]az°Cine,aconitane-8,13,14,15-tetrol deriv.
- CAS编号6900-87-4
- MFCD编号:MFCD00221744
- EINECS号:683-141-6
- FDA UNII编号:5207313N6E
- 分子式:C33H45NO10分子量:615.71
- 产品CID: 1684818
- 产品分类生物化工 → 中草药成分
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号121236-31-5 3-O-(imidazolyl... | CAS号3327-35-3 N-desethylaconitine | CAS号2752-64-9 新乌头碱； 中乌头碱 | CAS号302-27-2 乌头碱 | CAS号139617-07-5 3-O-(S-methyl)t... | CAS号64-19-7 冰醋酸 | CAS号65-85-0 苯甲酸合成工艺路线路线简述
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Xie S, Jia Y, Liu A, Dai R, Huang L. Hypaconitine-induced QT prolongation mediated through inhibition of KCNH2 (hERG) potassium channels in conscious dogs. J Ethnopharmacol. 2015 May 26;166:375-9. doi: 10.1016/j.jep.2015.03.023. Epub 2015 Mar 20. doi: 10.1002/bmc.2825. Epub 2012 Oct 2. doi: 10.1111/j.2042-7158.2012.01532.x. Epub 2012 May 11. Chinese. Chinese. doi: 10.3390/molecules20011560. doi: 10.1016/j.toxlet.2012.11.011. Epub 2012 Nov 28. doi: 10.1002/bmc.3102. Epub 2013 Dec 17. Chinese. Chinese. doi: 10.3109/00498254.2011.641608. Epub 2011 Dec 22. doi: 10.1016/j.ejphar.2010.10.030. Epub 2010 Oct 20. doi: 10.1016/j.toxlet.2011.04.015. Epub 2011 Apr 27. doi: 10.1177/1535370216685433. Epub 2017 Jan 5.
15: Kimura M, Muroi M, Kimura I, Sakai S, Kitagawa I. Hypaconitine, the dominant constituent responsible for the neuromuscular blocking action of the Japanese-sino medicine "bushi" (aconite root). Jpn J Pharmacol. 1988 Oct;48(2):290-3. doi: 10.1107/S1600536810039887.
18: Yu B, Cao Y, Xiong YK. Pharmacokinetics of aconitine-type alkaloids after oral administration of Fuzi (Aconiti Lateralis Radix Praeparata) in rats with chronic heart failure by microdialysis and ultra-high performance liquid chromatography-tandem mass spectrometry. J Ethnopharmacol. 2015 May 13;165:173-9. doi: 10.1016/j.jep.2015.01.057. Epub 2015 Feb 20. doi: 10.1016/j.jchromb.2010.08.032. Epub 2010 Sep 16.
合成参考文献
参考文献:10.1002/jms.1038
摘要:Kaneko R, Hattori S, Furuta S, Hamajima M, Hirata Y, Watanabe K, Seno H, Ishii A. Sensitive analysis of aconitine, hypaconitine, mesaconitine and jesaconitine in human body fluids and Aconitum tubers by LC/ESI-TOF-MS. J Mass Spectrom. 2006 Jun;41(6):810–4. doi: 10.1002/jms.1038.
参考文献:10.1107/s1600536810039887
摘要:Zheng LL, Li Y, Zi TY, Yuan MY. 8β-Acet-oxy-14α-benzo-yloxy-N-methyl-13β,15α-dihy-droxy-1α,6α,16β-trimeth-oxy-4β-(meth-oxy-meth-yl)aconitane: hypaconitine isolated from 'fuzi'. Acta Crystallogr Sect E Struct Rep Online. 2010 Oct 09;66(Pt 11):o2787–8.
参考文献:10.1002/pca.861
摘要:Jiang ZH, Xie Y, Zhou H, Wang JR, Liu ZQ, Wong YF, Cai X, Xu HX, Liu L. Quantification of Aconitum alkaloids in aconite roots by a modified RP-HPLC method. Phytochem Anal. 2005 Nov;16(6):415–21. doi: 10.1002/pca.861.
📝 需求与反馈
尽可能描述清楚需求与问题信息
