CAS: 68892-42-2; N-(9-((2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)-6-Oxo-6,9-Dihydro-1H-Purin-2-yl)Isobutyramide

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CAS号97-72-3 异丁酸酐 | CAS号961-07-9 2'-脱氧鸟苷 | CAS号68892-41-1 5'-O-(4,4'-二甲氧基... | CAS号1468-39-9 异戊酸酐 | CAS号82921-42-4 2'-deoxy-N2-iso... | CAS号440327-43-5 N-isobutyryl-3'... | CAS号82921-54-8 N-(9-((2R,4S,5R... | CAS号167872-08-4 N-isobutyroylde... | CAS号79-30-1 异丁酰氯 | CAS号961-07-9 2'-脱氧鸟苷 | CAS号68892-41-1 5'-O-(4,4'-二甲氧基... | CAS号16174-59-7 2'-deoxyguanosi... | CAS号82921-57-1 Guanosine,2'-de...

📜异丁酰氯,2'-脱氧鸟苷置于吡啶,Tea体系中,化学反应 3.0H,反应生成 N2-异丁酰基-2'-脱氧鸟苷
参考文献:Synthesis Of 5'-O-Amino-2'-Deoxypyrimidine And Purine Nucleosides: Building-Blocks For Antisense Oligonucleotides
标题:Synthesis Of 5'-O-Amino-2'-Deoxypyrimidine And Purine Nucleosides: Building-Blocks For Antisense Oligonucleotides
摘要:An Efficient Synthesis Of 5'-O-Amino-2'-Deoxy Analogs Of Uridine 1,Thymidine 2,Cytidine 3,5-Methylcytidine 3A,Adenosine 4,And Guanosine 5 Was Accomplished. The Key Step Of 5'-O-N-Bond Formation In 2'-Deoxynucleosides 1-5 Was Achieved Via A Mitsunobu Reaction In Excellent Yields. The 5'-O-Amino Nucleosides 1-5 Are Useful Building-Blocks For The Synthesis Of Nucleoside Dimers Linked By A Methylene(Methylimino) (Mmi) Bridge. Mmi Is A Novel Phosphate Surrogate For Antisense Oligonucleosides.
DOI:10.1021/jo00121A037

专利信息

专利号:WO-2024082545-A1
优先权日:2022-10-21
标 题:Method for enzymatic synthesis of nucleoside containing protecting group, and composition
发明人：HONG HAO; JAMES GAGE; XIAO YI; ZHANG NA; JIAO XUECHENG; LI MINGJI; LI RUI; DING SHIMAO
权利人:ASYMCHEM LIFE SCIENCE TIANJIN CO LTD
摘要:The present invention provides a method for enzymatic synthesis of a nucleoside containing a protecting group, and a composition. The method comprises: using pyrimidine nucleoside phosphorylase or uracil nucleoside phosphorylase and purine nucleoside phosphorylase to catalyze a substrate to synthesize a nucleoside containing a protecting group, wherein the substrate comprises a substrate nucleoside, a substrate base and a substrate phosphate, and the substrate base contains a protecting group; the pyrimidine nucleoside phosphorylase comprises a protein which has more than 80% homology with a protein PyNP shown in SEQ ID NO: 1; the uracil nucleoside phosphorylase comprises a protein which has more than 80% homology with a protein UP shown in SEQ ID NO: 2; and the purine nucleoside phosphorylase comprises a protein which has more than 80% homology with a protein PNP shown in SEQ ID NO: 3, 7 or 8. The present invention can solve the problem in the prior art that there is no biosynthesis method to produce a nucleoside containing a protecting group, and is suitable for the field of enzyme catalysis.

专利号:US-5021550-A
优先权日:1986-10-07
标 题 :Method for preventing deletion sequences in solid phase synthesis
发明人：ZEIGER ALLEN R
权利人:UNIV JEFFERSON
摘要:Improved methods for solid-state synthesis of polymers, especially polypeptides and polynucleotides, are provided. In accordance with a preferred embodiment, selectively activatable and reactive bonding moieties are covalently bonded to solid supports for polynucleotide and polypeptide syntheses. Products of failed reactions and some side products are caused to react with the selectively activatable and reactive bonding moiety to cause divalent bonding of unwanted products to the solid support. Upon cleavage of the initial situs of covalent bonding to the solid support, desired products are free to be collected while unwanted products remain covalently bonded to the support. Ease of purification of such polymers is a principal object of the present invention. The methods of the invention are amenable to automation and digital control and novel solid supports, activatable, reactive bonding moieties and other compositions are presented. The expression of polynucleotides prepared in accordance with preferred embodiments produces novel polypeptides.

专利号:US-5096825-A
优先权日:1983-01-12
标 题:Gene for human epidermal growth factor and synthesis and expression thereof
发明人：BARR PHILIP J; MERRYWEATHER JAMES P; MULLENBACH GUY T; URDEA MICKEY S; VALENZUELA PABLO
权利人:CHIRON CORP
摘要:A DNA having a base sequence coding for human epidermal growth factor has been synthesized in blocks, and cloned. Novel recombinant DNA transfer vectors containing said cloned DNA have been constructed. The codon usage of the sequence reflects the codon bias of yeast. The DNA sequence is useful for the large scale synthesis of human epidermal growth factor in yeast cells or microorganisms transformed by said recombinant DNA transfer vectors.

专利号:WO-0018778-A9
优先权日:1998-09-29
标题:Synthesis of codon randomized nucleic acids
发明人：LOHSE PETER; KUIMELIS ROBERT G
权利人:PHYLOS INC
摘要:A method for generating a selected set of codons is disclosed; the method includes the steps of: (a) providing a first set of mononucleosides, mononucleotides, dinucleotides, or mixture thereof, where a subset A of the first set is protected with a protecting group A', and a subset B of the first set is protected with a protecting group B', where A' and B' are orthogonal protecting groups; (b) selectively removing the protecting group A' from subset A; (c) coupling the products of step (b) with a second set of mononucleosides, mononucleotides, dinucleotides, or a mixture thereof, where the second set is protected with protecting group A'; (d) optionally removing protecting group A' from the products of step (c); (e) optionally coupling the products of step (d) with a third set of mononucleosides, where the third set is protected with protecting group A'; (f) selectively removing the protecting group B' from subset B; (g) coupling the products of step (f) with a fourth set of mononucleosides, mononucleotides, dinucleotides, or a mixture thereof, where the fourth set is protected with protecting group A' or protecting group B'; (h) optionally selectively removing protecting group B' from the products of step (g); and (i) optionally coupling the products of step (h) with a fifth set of mononucleosides, to yield a selected set of codons.

专利号:US-4500707-A
优先权日:1980-02-29
标题:Nucleosides useful in the preparation of polynucleotides
发明人：CARUTHERS MARVIN H; MATTEUCCI MARK D
权利人:UNIVERSITY PATENTS INC
摘要:New and useful intermediate nucleotides bound to an inorganic polymer support, including the preparation thereof, and processes for the conversion to oligonucleotides which are especially useful for the synthesis of polynucleotides, particularly ribonucleic (RNA) and deoxyribonucleic acids (DNA).

专利号:WO-2024044792-A1
优先权日:2022-08-26
标 题 :Universal solid supports and phosphoramidite building blocks for oligonucleotide synthesis
发明人：GUZAEV ANDREI PAVEL; GOGOI KHIRUD; SHENG SUZIE; OSKARI HARRI
权利人:AM CHEMICALS LLC
摘要:Disclosed herein are chemical preparation of oligonucleotides, chemical entities useful in such preparation, processes for such preparation, and methods of use relating to the chemical preparation of oligonucleotides. Further disclosed herein are novel universal solid supports and phosphoramidite building blocks for oligonucleotide synthesis on solid phase that effect the removal of the 3'-phosphate moieties during the course of oligonucleotide deprotection.