CAS: 66762-68-3; Ethyl 4-Methoxy-3-Oxobutanoate

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CAS号638-07-3 4-氯乙酰乙酸乙酯 | CAS号38870-89-2 甲氧基乙酰氯 | CAS号105-36-2 溴乙酸乙酯 | CAS号13176-46-0 4-溴乙酰乙酸乙酯 | CAS号124-41-4 甲醇钠 | CAS号3122-78-9 6-(甲氧基甲基)嘧啶-4-醇 | CAS号79534-96-6 2-Butenoic acid... | CAS号89966-94-9 6-(methoxymethy... | CAS号406169-91-3 4-(methoxymethy...

4-氯乙酰乙酸乙酯置于sodium Hydride体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 2.0H,反应生成 4-甲氧基乙酰乙酸乙酯
参考文献:Diphenylpyridine Derivatives,Preparation And Therapeutic Application Thereof
标题:Diphenylpyridine Derivatives,Preparation And Therapeutic Application Thereof
摘要:该发明涉及一般式(I)的5,6-二苯基吡啶-3-羧酰胺衍生物,其中:R1代表氢或(C1-C4)烷基;r2代表:一个含有5至7个原子的单氮饱和杂环,氮原子被(C1-C4)烷酰基取代;nr10R11;一个非芳香性的(C3-C10)碳环,三个以上的位置被(C1-C4)烷基取代;一个非芳香性的(C11-C12)碳环,未被取代或被单烷基或多烷基取代;一个含有5至7个原子的单氧饱和杂环,三个以上的位置被(C1-C4)烷基取代;或者r1和r2与上述连接的氮原子一起形成4-二取代哌啶-1-基团;以及其盐,溶剂合物和水合物.该发明还涉及其生产方法和治疗应用.

专利信息

专利号:US-5767131-A
优先权日:1993-04-05
标 题 :Dihydropyridines and new uses thereof
发明人：GLUCHOWSKI CHARLES; WETZEL JOHN M; CHIU GEORGE; MARZABADI MOHAMMED R; WONG WAI C; NAGARATHNAM DHANAPALAN
权利人:SYNAPTIC PHARMA CORP
摘要:The invention provides a method of treating benign prostatic hyperplasia in a subject which comprises administering to the subject a therapeutically effective amount of a compound having the structure: ##STR1## wherein Y is --(CH 2 ) n --, where n is 1, 2, 3, 4 or 5; --(CH 2 ) h --O--(CH 2 ) k --, where h and k are independently the same or different and are 2, 3 or 4; --(CH 2 ) h --CHâ•?CH--(CH 2 ) k --; or --(CH 2 ) h --C.tbd.C--(CH 2 ) k --, where h and k are independently the same or different and are 1, 2, 3 or 4; wherein Z is O, NH, or CH 2 ; wherein R 1 is a linear or branched chain alkyl, alkoxyalkyl or arylalkyl group; wherein R 2 and R 4 are independently the same or different and are H, or a linear or branched chain alkyl group; wherein R 3 is H, a linear or branched chain alkyl, alkoxy, alkoxyalkyl or acyl group; and wherein R 5 and R 6 are independently the same or different and are H, OH, Cl, Br, F, NO 2 , CN, CF 3 , or NH 2 , or a linear or branched chain alkyl, alkoxy, alkoxycarbonyl, acyl, alkylsulfoxide, alkylsulfone, or mono- or dialkylamino group. Other active compounds containing one, two or three rings are also disclosed as well as pharmaceutical compositions prepared therefrom and methods of use in the treatment of BPH, inhibition of cholesterol synthesis, and reduction of intraocular pressue.

专利号:US-6608086-B2
优先权日:1993-04-05
标 题:Dihydropyridines and new uses thereof
发明人：GLUCHOWSKI CHARLES; WETZEL JOHN M; CHIU GEORGE; MARZABADI MOHAMMED R; WONG WAI C; NAGARATHNAM DHANAPALAN
权利人:SYNAPTIC PHARMA CORP
摘要:This invention provides dihydropyridines useful for treatment of prostatic hyperplasia, inhibition of cholesterol synthesis, and/or reduction of intraocular pressure.