CAS: 6012-97-1; Perchlorothiophene

该化合物是一种硫苯的氯化衍生物,其特点是硫苯的碳原子中含有4个氯原子,该化合物通常呈现黄色至褐色的灰色,以其独特的芳香气味闻名.这是一种杂交化合物,其含环结构至少包含一个原子,而在此情况下,该原子不是碳欧元,硫.多种氯替代成分的存在对其化学特性产生重大影响,使其反应性更大,而且可能比非氯化对应物更具毒性.2,3,4,5-四氯二苯经常用于各种工业用途,包括作为农用化学品和药物合成的中间体.其环境持久性和潜在生物累积性引起了对生态影响的担忧.在处理该化合物时,应采取安全措施,因为吸入或皮肤接触可能会对健康造成危害.适当的储存和处置做法对于减轻与使用该化合物相关的任何潜在危害至关重要.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

thiophene 2-bromothiophene 2,5-dibromothiophen 2,2,3,4,5,5-hexachloro-tetrahydro-thiophene2,3,4-trichlorothiophene hexachloro-2,5-dihydro-thiophene 3,4,5-trichlorothiophene-2-carboxylic acid 2-chloro-heptafluoro-2-butene

合成工艺路线路线简述

    📜四氯乙烯置于硫化氢体系中,化学反应 15.5H,以74%的收率获得产物四氯噻吩
    参考文献:合成四氯噻吩的新方法
    标题:合成四氯噻吩的新方法
    摘要:
    DOI:10.1007/bf02401713

    专利信息


    专利号:WO-2025019747-A1
    优先权日:2023-07-20
    标题:Processes for the production of z-1,1,1,4,4,4-hexafluoro-2-butene intermediates and compositions thereof
    发明人:PENG SHENG
    权利人:CHEMOURS CO FC LLC
    摘要:Methods of synthesis of intermediates, such as 2-chloro-1,1,1,4,4,4-hexafluoro-2-butene and 2,3-dichloro-1,1,1,4,4,4-hexafluoro-2-butene, which can be used in the production fluorinated olefins, such as 1,1,1,4,4,4-hexafluoro-2-butene, from hexafluorobutadiene, are provided.

    专利号:WO-2021074309-A1
    优先权日:2019-10-16
    标 题:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives as fungicides for combating specific phytopathogens
    发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; SEN INDIRA; BIERI STEPHANE; DIGGELMANN MARTIN
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)

    专利号:WO-2021074311-A1
    优先权日:2019-10-16
    标题:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives as fungicides for combating specific phytopathogens
    发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; BIERI STEPHANE; DIGGELMANN MARTIN
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola, Monographella nivalis, Fusarium culmorum and/or Gibberella zeae when spayed on plants) (e.g. pages 47 to 55; examples A1 and A2; compounds E.01 to E.17; table E). An exemplary compounds is e.g.: 3-(5-bromo-3,3-dimethyl-2,4-dihydro-1 H-isoquinolin-1-yl)-8-fluoro- quinoline (example A1)

    专利号:US-12404296-B2
    优先权日:2018-02-22
    标 题 :Poly(A)-ClickSeq click-chemistry for next generation 3-end sequencing without RNA enrichment or fragmentation
    发明人:ROUTH ANDREW; WAGNER ERIC J; JI PING; JAWORSKI ELIZABETH
    权利人:UNIV TEXAS
    摘要:The present invention includes a method and kit for cDNA synthesis of a 3′UTR/poly(A) tail junction of cellular RNA comprising: obtaining RNA comprising a 3′UTR/poly(A) junction and a poly(a) tail; combining the RNA with three terminating nucleotides of modified-deoxyGTP, modified-deoxyCTP and modified-deoxyATP, dNTPs, and adaptor sequence-oligo-dT; performing reverse transcription of the RNA with a reverse transcriptase primed with the adaptor sequence-oligo-dT to form terminated cDNA fragments that are stochastically terminated upstream of the 3′UTR/poly(A) junction, but not within the poly(A) tail; isolating the terminated cDNA fragments; chemically ligating a functionalized 5′ adaptor to the terminated cDNA; and amplifying the chemically-ligated cDNA into an amplification product, wherein the cDNA is enriched for sequences at the 3′UTR/poly(A) tail junction without fragmentation or enzymatic ligation.

    专利号:US-11162134-B2
    优先权日:2016-04-01
    标 题 :Methods of whole transcriptome amplification
    发明人:ZONG CHENGHANG
    权利人:BAYLOR COLLEGE MEDICINE
    摘要:Embodiments of the disclosure encompass highly sensitive and quantitative methods for single-cell sequencing of total RNA. In particular cases, methods utilize annealing of multiple primers to RNA, polytailing of single stranded DNA reverse transcribed therefrom, and utilization of bar codes in primers for amplification of amplicons produced from second strand synthesis.

    专利号:US-2017191094-A1
    优先权日:2015-12-31
    标题 :Expression of type i fatty acid synthase genes in eukaryotic algae
    发明人:MOELLERING ERIC; XU WEIDONG; VERRUTO JOHN H; ROESSLER PAUL GORDON
    权利人:SYNTHETIC GENOMICS INC
    摘要:The present invention provides recombinant algae expressing exogenous Type I fatty acid synthase (FAS) genes and demonstrating higher rates of fatty acid synthesis with respect to control microorgansims. The recombinant algae are able to produce greater amounts of FAME lipids under nitrogen replete conditions.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: John W Hull Jr, Et Al. Development Of Potential Manufacturing Routes For Substituted Thiophenes--Preparation Of Halogenated 2-Thiophenecarboxylic Acid Derivatives As Building Blocks For A New Family Of 2,6-Dihaloaryl 1,2,4-Triazole Insecticides. Beilstein J Org Chem. 2007 Sep 4:3:23.

    合成参考文献


    摘要:Schatz, J.; Seler, M., Science of Synthesis Knowledge Updates, (2011) 2, 435.
    摘要:World Review of Pest Control., 9(119), 1970
    摘要:U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals., NX#00063
    摘要:Pesticide Index, Frear, E.H., ed., State College, PA, College Science Pub., 1969, 5(219), 1976
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