CAS: 5796-98-5; Bis-Trimethylsilanyl Peroxide

上下游产品

1,1,2,2-tetraphenyl-1,2-bis(trimethylsilyloxy)ethaneIsopropylbenzene 1-styrenyloxytrimethylsilane pentamethyl(phenyl)disiloxane bis(trimethylsilyl)sulphate

📜2,3,5,6-Tetramethyl-1,4-Bis(Trimethylsilyl)-1,4-Diaza-2,5-Cyclohexadiene置于氧气体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 双(三甲基硅基)过氧化物
参考文献:有机硅试剂对o2的活化产生了有效o转移反应的h2O2或(me3Si)2O2定量
标题:有机硅试剂对o2的活化产生了有效o转移反应的h2O2或(me3Si)2O2定量
摘要:分子氧是动力学惰性的,很少用作低温选择性氧化反应的主要氧化剂.在这里,我们表明,直径:2被转化成h 2 ö 2在环境温度和大气压下几乎定量的产率(98%)中的双(三甲基硅烷基)存在下-1,4-环己二烯1.同样,O 2与二氢双(三甲基甲硅烷基)紫精2和吡嗪3的反应在低温下可产生优异的双(三甲基甲硅烷基)过氧化物(btsp)(最高可达99%).两种方法都证明,现成的有机硅试剂能够实现单加氧酶辅酶(如fadh)通常观测到的化学反应2和fmnh 2,在生物系统中,或通过工业蒽醌工艺在较高压力下使用.直接从o 2高效合成H2O 2和btsp对于制备相应的o-17和o-18标记的试剂而无需大量过量的o 2尤其有吸引力.这些通过两步一锅法在o原子与各种有机或无机底物的o原子转移反应中得以展示,从而使按o标记的大型化合物文库的快速和按需合成成为可能.
DOI:10.1002/hlca.201800156

专利信息

专利号:US-8138330-B2
优先权日:2006-09-11
标 题 :Process for the synthesis of oligonucleotides
发明人：LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED
权利人:LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED; SIGMA ALDRICH CO LLC
摘要:The present invention discloses novel methods for the synthesis of oligonucleotides with nucleoside phosphoramidites on solid supports. The methods comprise the stepwise chain assembly of oligonucleotides on supports with 5′-acyl phosphoramidites. The synthesis cycles consist of a front end deprotection step which is conducted with a solution of a primary amine or a phenolate, a phosphoramidite coupling step with a 5′-acyl nucleoside phosphoramidite in the presence of an activator, a phosphite oxidation step and an optional capping step. The novel methods improve the quality of synthetic oligonucleotides due to the irreversibility of the front end deprotection step, which prevents the formation of deletion sequences, and due to the avoidance of acidic reagents in the synthesis cycles, which prevent the formation of depurination side products. The invention further discloses novel nucleoside phosphoramidite compositions wherein the phosphoramidites carry acyl front end protective groups which are cleavable with primary amines or phenolates. The invention is applicable to the synthesis of oligodeoxyribonucleotides, oligoribonucleotides and oligonucleotides with modifications in their sugar or phosphate groups.

专利号:US-10253153-B2
优先权日:2015-04-24
标题 :Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support
发明人：MAETA ERI; MORI KENJIRO; HORIE SHOHEI; ITO TAKAHIKO; SAITO SHOICHIRO; NAGAO RYUHEI
权利人:NITTO DENKO CORP
摘要:The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: n nwherein each symbol is as defined in the SPECIFICATION.

专利号:US-10730904-B2
优先权日:2012-11-14
标 题:Method for liquid-phase synthesis of nucleic acid
发明人：NONOGAWA MITSURU; NAGATA TOSHIAKI; SAITO HIDEKI; YASUMA TSUNEO
权利人:TAKEDA PHARMACEUTICALS CO
摘要:In this method, an oligonucleotide represented by formula (II) [wherein Y 1 , Q, Base, r and r′ are each as defined in claim 1 ] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3 and n are each as defined in claim 1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

专利号:US-7504524-B2
优先权日:2004-07-26
标题:Method for synthesis of 2,5-dioxane-1,4-diones
发明人：BOURISSOU DIDIER; MARTIN-VACA BLANCA; BEN FREDERIC; GRAULLIER MAGALIE; CHERIF-CHEIKH ROLAND; MONTES MARTIN
权利人:SOD CONSEILS RECH APPLIC
摘要:The invention relates to a novel method for the synthesis of 2,5-dioxane-1,4-diones having formula (I), comprising the oxidation of the ketone function of a cyclic compound having formula (II), wherein R 1 , R 2 , R 3 and R 4 independently represent the hydrogen atom, halo, (C 2 -C 6 ) alkenyl, (C 3 -C 7 )cycloalkyl, cyclohexenyl and a radical having formula —(CH 2 ) m —V—W.

专利号:US-5324831-A
优先权日:1988-04-06
标题:Phosphoramidite reagent for chemical synthesis of modified DNA
发明人：MARQUEZ VICTOR E; GODDARD AMANDA J
权利人:US HEALTH
摘要:5,6-dihydro-5-azacytidine phosphoramidite is useful in the synthesis of oligonucleotides and DNA containing dihydro-5-aza- and 5-azacytosine bases. The modified oligonucleotides which contain 5-azacytosine residues at specific sites can be used to determine the mechanism of selective gene activation and the relationship existing between the presence of the triazine base and inhibition of DNA methylation.

专利号:WO-2022191172-A1
优先权日:2021-03-09
标题:Linker and carrier for nucleic acid solid phase synthesis
发明人：HARI YOSHIYUKI; FUCHI YASUFUMI; YAMAMOTO KAZUKI; ITO YUTA
权利人:LIID PHARMACEUTICALS INC
摘要:The present invention provides: a universal linker for synthesis of a nucleic acid solid phase, represented by formula (I), which makes it possible to suppress the occurrence of byproducts and which makes it possible to synthesize DNA and RNA of high purity with greater efficiency; and a carrier for nucleic acid solid phase synthesis which carries the linker. [In the formula, each symbol is as defined in the description.]