CAS: 56632-86-1; (R)-2-Amino-3-(6-Chloro-1H-Indol-3-yl)Propanoic Acid

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CAS号57233-87-1 (2S)-3-(6-chlor... | CAS号56777-76-5 N-乙酰基-6-氯-D-色氨酸 | CAS号50517-10-7 N-乙酰基6-氯色氨酸

📜6-氯-Dl-色氨酸置于ivoa Acetyltransferase,5'-三磷酸腺苷,Magnesium Chloride体系中,用 Aq. Phosphate Buffer 作为反应溶剂,化学反应 12.0H,以98%的收率获得产物
参考文献:Complete Stereoinversion Of L-Tryptophan By A Fungal Single-Module Nonribosomal Peptide Synthetase
标题:Complete Stereoinversion Of L-Tryptophan By A Fungal Single-Module Nonribosomal Peptide Synthetase
摘要:Single-Module Nonribosomal Peptide Synthetases (Nrpss) And Nrps-Like Enzymes Activate And Transform Carboxylic Acids In Both Primary And Secondary Metabolism And Are Of Great Interest Due To Their Biocatalytic Potentials. The Single-Module Nrps Ivoa Is Essential For Fungal Pigment Biosynthesis. Here,We Show That Ivoa Catalyzes Atp-Dependent Unidirectional Stereo Inversion Of L-Tryptophan To D-Tryptophan With Complete Conversion. While The Stereoinversion Is Catalyzed By The Epimerization (E) Domain,The Terminal Condensation (C) Domain Stereoselectively Hydrolyzes D-Tryptophanyl-S-Phosphopantetheine Thioester And Thus Represents A Noncanonical C Domain Function. Using Ivoa,We Demonstrate A Biocatalytic Stereoinversion/deracemization Route To Access A Variety Of Substituted D-Tryptophan Analogs In High Enantiomeric Excess.
DOI:10.1021/jacs.9B08898

专利信息

专利号:US-2022243244-A1
优先权日:2019-10-10
标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
发明人：ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-8975046-B2
优先权日:2005-04-26
标 题 :Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
发明人：BRAZEAU BRIAN J; DE SOUZA MERVYN L; GORT STEVEN J; HICKS PAULA M; KOLLMANN SHERRY R; LAPLAZA JOSE M; MCFARLAN SARA C; SANCHEZ-RIERA FERNANDO A; SOLHEID CHRISTOPHER
权利人:BRAZEAU BRIAN J; DE SOUZA MERVYN L; GORT STEVEN J; HICKS PAULA M; KOLLMANN SHERRY R; LAPLAZA JOSE M; MCFARLAN SARA C; SANCHEZ-RIERA FERNANDO A; SOLHEID CHRISTOPHER; CARGILL INC
摘要:Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.

专利号:WO-2021072167-A1
优先权日:2019-10-10
标 题:Compositions and methods for in vivo synthesis of unnatural polypeptides