CAS: 56074-20-5; Boc-Dl-Ida-Oh

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tert-butyl dicarbonatedi-tert-butyl dicarbonate iminodiacetic acid 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile rac-tert-butyl (3R,4S)-3,4-dihydroxypyrrolidine-1-carboxylateN-((tert-butyloxy)carbonyl)-N'-cyclohexyliminodiacetic acid monoamide ({[Benzyl-(2-{benzyl-[2-(tert-butoxycarbonyl-carboxymethyl-amino)-acetyl]-amino}-ethyl)-carbamoyl]-methyl}-tert-butoxycarbonyl-amino)-acetic acid N,N'-bis(N-(2-(4-fluorophenyl)ethyl)carboxamidomethyl)-N,N'-bis(N,N-di(2-methoxyethyl)carboxamidomethyl)-N''-((tert-butoxy)carbonyl)iminodiacetic acid diamide N,N'-bis(N-(2-(4-methoxyphenyl)ethyl)carboxamidomethyl)-N,N'-bis(N,N-di(2-methoxyethyl)carboxamidomethyl)-N''-((tert-butoxy)carbonyl)iminodiacetic acid diamide

📜二碳酸二叔丁酯置于甲烷磺酸,水,Lithium Hydroxide体系中,用 2-甲基四氢呋喃 作为反应溶剂,化学反应生成 N-Boc-亚氨基二乙酸
参考文献:一种托法替布的有关物质及其制备方法和应 用
标题:一种托法替布的有关物质及其制备方法和应 用
摘要:本发明公开了一种托法替布的有关物质及其制备方法和应用,该物质的系统命名为:N,N'‑二乙酰{(3R,4R)‑4‑甲基‑3‑[甲基(7H‑吡咯并[2,3‑d]嘧啶‑4‑基)氨基]哌啶‑1‑基}亚胺.该杂质在缩合反应过程中反应生成水平较低,但由于该杂质与托法替布的主要官能基团一致,在后续成盐,精制过程中的清除效果有限,对托法替布原料药及制剂成品的质量影响较大.通过检测该杂质的存在,可以有效确定托法替布原料及制剂的质量.

专利信息

专利号:US-6653087-B1
优先权日:1997-02-07
标 题 :Convergent synthesis of combinatorial library
发明人：BOGER DALE L
权利人:SCRIPPS RESEARCH INST
摘要:Targeted C2-symmetric and unsymmetric chemical libraries for use in protein and receptor homodimerization and heterodimerization are constructed by solution phase methodologies. Exemplary libraries are prepared in a 60 to 10 sub-library format by symmetrical coupling of the constructed fragments with a mixture of tethering dicarboxylic acids. In each step of the 3-step reaction sequence, the reactants, unreacted starting material, reagents and their byproducts were removed by simple liquid-liquid or liquid-solid extractions providing the desired intermediates and final libraries in multi-milligram quantities in high purities (≧90-100%) independent of the reaction yields and without deliberate reaction optimization. The synthesis of a second prototypical library employed the olefin metathesis reaction to join and combinatorially randomize the length of linker tether. This approach provides a unique opportunity to rapidly generate a statistically controlled mixture of homo and heterodimers of remarkable diversity.

专利号:US-6245937-B1
优先权日:1996-11-29
标题 :Liquid phase parallel synthesis of chemical libraries
发明人：CHENG SOAN; SAUNDERS JOHN
权利人:DUPONT PHARMACEUTICALS RES LAB
摘要:This invention features methods of biphasic synthesis for synthesizing combinatorial libraries and combinatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this invention.

专利号:US-6194612-B1
优先权日:1995-10-17
标 题:Template for solution phase synthesis of combination libraries
发明人：BOGER DALE L; CHENG SOAN; MYERS PETER L
权利人:SCRIPPS RESEARCH INST; COMBICHEM INC
摘要:This invention features a template for synthesizing combinatorial libraries, methods of synthesizing combiatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this invention.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-5635598-A
优先权日:1993-06-21
标 题:Selectively cleavabe linners based on iminodiacetic acid esters for solid phase peptide synthesis
发明人：LEBL MICHAL; KRCHNAK VIKTOR; KOCIS PETR; LAM KIT S
权利人:SELECTIDE CORP
摘要:The present invention is directed to linkers based on ester bond linkages, especially iminodiacetic acid ester bond linkages, for use in solid phase peptide synthesis. In particular, the invention is directed to cleavable linkers that can release peptide from the solid phase support under relatively mild conditions by formation of a diketopiperazine or other cyclic structure, such that the cyclic structure remains on the solid phase support, and, in a second cleavage, under more stringent conditions of high pH. The invention is further directed to solid phase supports prepared with multiple cleavable linkers, including a linker that is cleaved by formation of a cyclic product. One such second linker is an ester of hydroxymethylbenzoic acid, or esters formed by carboxy groups of aspartic or glutamic acid.

专利号:US-2002048774-A1
优先权日:1996-11-29
标题 :Liquid phase parallel synthesis of chemical libraries