CAS: 55854-46-1; 5-Bromo-2-Thiophenesulfonyl Chloride

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CAS号53595-65-6 5-溴噻吩-2-磺酰胺 | CAS号68848-50-0 5-溴-N,N-二甲基噻吩-2-磺酰胺 | CAS号81597-52-6 5-Bromo-thiophe... | CAS号81597-64-0 4-(5-Bromo-thio...

2-溴噻吩置于氯磺酸体系中,化学反应生成 5-溴噻吩-2-磺酰氯
参考文献:噻吩-2-磺酰基自由基的结构和构象研究
标题:噻吩-2-磺酰基自由基的结构和构象研究
摘要:描述了各种光化学产生的噻吩-2-磺酰基的esr光谱.它们的自旋分布是σ自由基的典型特征.在所有可及的温度下,位置3处没有取代基的自由基均表现出相对较快的绕c-s键旋转,而3-溴取代的自由基则表现出显着的构象偏好,这是根据π型共轭结构来解释的.这些发现也被对具有so 2和杂芳族部分的不同相对排列的未取代的噻吩-2-磺酰基基团进行的indo计算结果所证实.
DOI:10.1039/p29860001179

专利信息

专利号:US-2007275968-A1
优先权日:2004-09-07
标 题 :Substituted Biphenyl Derivative
发明人：KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
权利人:KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
摘要:The present invention relates to a biaryl derivative or a pharmacologically acceptable salt thereof having an excellent collagen-synthesis inhibition activity. A biaryl derivative having a structure represented by the following General Formula (I) or a pharmacologically acceptable salt thereof: n nwherein n R 1 represents a C 6 -C 10 aryl group which is substituted with one to three group(s) each independently selected from the group consisting of a group defined by formula R-L-, a di-(C 1 -C 6 alkyl)amino group, a di-(C 1 -C 6 alkyl)aminosulfonyl group, a hydroxyaminocarbonyl group, and a halogen atom, and so on; R represents a C 1 -C 6 alkyl group, and so on; L represents a sulfonyl group, an aminosulfonyl group, or a sulfonylamino group, and so on; R 2 represents a hydrogen atom, and so on; A represents a group defined by formula (II), (III), or (IV); R 3 represents a C 1 -C 6 alkyl group, and so on; and R 4 represents a C 1 -C 6 alkyl group, and so on.