CAS: 518-94-5; (11R,51R)-16,17,56,57-Tetramethoxy-12,52-Dimethyl-11,12,13,14,51,52,53,54-Octahydro-2,6-Dioxa-1(8,1),5(1,8)-Diisoquinolina-3,7(1,4)-Dibenzenacyclooctaphane

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CAS号186581-53-3 重氮甲烷 | CAS号477-62-3 Is°Chondrodendrine | CAS号524-20-9 杏黄罂粟碱

合成工艺路线路线简述

    📜Cycleanine α-N-Oxide置于亚硫酸体系中,用 水 作为反应溶剂,化学反应 8.0H,反应生成 轮环藤碱
    参考文献:Synthesis Of Cycleanine Mono-N-Oxides
    标题:Synthesis Of Cycleanine Mono-N-Oxides
    摘要:Oxidation Of Cycleanine (3) With M-Chloroperbenzoic Acid Gave Two Diastereomeric N-Oxides (1 And 2),And Their Stereochemistry Was Unambiguously Determined On The Basis Of Spectroscopic Evidence. The NMR Spectra Of Synthetic Cycleanine Mono-N-Oxides 1 And 2 Were Significantly Different From Those Of The Natural Product Previously Reported To Be Cycleanine N-Oxide.
    DOI:10.1021/np970362T

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    专利信息


    专利号:CN-104892534-A
    优先权日:2015-05-18
    标 题 :The Synthesis Process of Gadolinium Contrast Agent Intermediate Trigonine

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Uche FI, McCullagh J, Claridge TWD, Richardson A, Li WW. Synthesis of (aminoalkyl)cycleanine analogues: cytotoxicity, cellular uptake, and apoptosis induction in ovarian cancer cells. Bioorg Med Chem Lett. 2018 May 15;28(9):1652-1656. doi: 10.1016/j.bmcl.2018.03.038. Epub 2018 Mar 16. 65(2):e01995-20. doi: 10.1128/AAC.01995-20.
    3: Uche FI, Drijfhout FP, McCullagh J, Richardson A, Li WW. Cytotoxicity Effects and Apoptosis Induction by Bisbenzylisoquinoline Alkaloids from Triclisia subcordata. Phytother Res. 2016 Sep;30(9):1533-9. doi: 10.1002/ptr.5660. Epub 2016 Jun 8. 66(3):379-85. doi: 10.1016/s0006-2952(03)00210-7. 12(2):182-7. doi: 10.1111/j.1472-8206.1998.tb00939.x. 33(5):622-627. doi: 10.1080/14786419.2017.1402319. Epub 2017 Nov 10. 154(3):537-63. doi: 10.1016/j.jep.2014.04.024. Epub 2014 Apr 25. 93(2-3):331-5. doi: 10.1016/j.jep.2004.04.006. 102(1):89-94. doi: 10.1016/j.jep.2005.05.021. 1(1):23-7. Chinese.

    合成参考文献


    参考文献:10.1016/0006-2952(93)90628-a
    摘要:Kondo Y, Takano F, Hojo H. Inhibitory effect of bisbenzylisoquinoline alkaloids on nitric oxide production in activated macrophages. Biochem Pharmacol. 1993 Dec 03;46(11):1887–92. doi: 10.1016/0006-2952(93)90628-a.
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