CAS: 50632-57-0; 2-Methoxy-2,4-Diphenylfuran-3-One

该化合物是一种有机化合物,其特征为呋喃结构,包括一个与碳基组结合的松木环,该化合物有两种苯基组和一个甲基氧替代体,有助于其独特的化学特性,在室温下一般是固体,可能根据纯度和具体配制表现出多种颜色;甲基氧组的存在,增强了其在有机溶剂中的溶解性,而苯基组则可以影响其再活动性和稳定性;该化合物可能在不同领域,包括有机合成和材料科学领域,具有兴趣,因为它在制药,农用化学品或作为有机反应的建筑构件中具有潜在应用性,其特定的回作用和相互作用将取决于现有功能组和使用时的条件;处理和储存任何化学物质时,都应参考安全数据.

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38183-12-9 192451-60-8

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CAS号60792-81-6 4-(diethylamino...

合成工艺路线路线简述

    📜1,3-二苯基丙烷-1,2-二酮 以 甲醇,乙醇,氯仿,N,N-二甲基甲酰胺二甲基缩醛,Petroleum Ether 作为反应溶剂,化学反应生成 2-甲氧基-2,4-二苯基-3(2H)-呋喃酮
    参考文献:Fluorogenic 2-Oxy-3(2H)-Furanone Materials
    标题:Fluorogenic 2-Oxy-3(2H)-Furanone Materials
    摘要:分子式为##spc1##的化合物,其中r.Sub.1是较低的烷基或苯较低的烷基;r.Sub.2是苯或取代苯;r.Sub.3是取代或未取代的苯基,萘基或吲哚基.这些化合物是荧光试剂,可与一级氨基团反应形成荧光物质.上述化合物可用于生物重要物质的荧光标记.

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    专利信息


    专利号:US-6624144-B1
    优先权日:1998-03-18
    标 题:Matrix metalloproteinase inhibitors and down-regulators
    发明人：KOIVUNEN ERKKI; SORSA TIMO; SALO TUULA
    权利人:CTT CANCER TARGETING TECH OY
    摘要:The present invention relates to novel matrix metalloproteinase (MMP) inhibitors and down-regulators, to a process for the preparation of these inhibitors, to pharmaceutical compositions comprising these inhibitors/down-regulators, to the use of the novel MMP inhibitors for the manufacture of pharmaceutical and research preparations, to a method for inhibiting and down-regulating MMP-dependent conditions either in vivo or in vitro, to a method for inhibiting formation, synthesis, expression activations, and/or functions as well as actions of matrix metalloproteinases, and to the use of the novel MMP inhibitors and down-regulators in biochemical isolation and purification procedures of matrix metalloproteinases.

    专利号:US-6911318-B2
    优先权日:1999-03-03
    标 题:Bacterial transglycosylases: assays for monitoring the activity using Lipid II substrate analogs and methods for discovering new antibiotics
    发明人：KAHNE SUZANNE WALKER
    权利人:UNIV PRINCETON
    摘要:This invention provides a direct method for monitoring bacterial transglycosylase activity using labeled substrates produced by chemo-enzymatic synthesis wherein the labels are selected to permit the detection of both polymeric and non-polymeric products simultaneously, either directly or following the separation of product from starting material. The invention promotes the discovery of new antibiotics with activity against bacterial transglycosylases by a) laying the groundwork for structural analysis of purified, active transglycosylase (which permits structure-based design); and b) providing an assay that can be used to screen for inhibitors.

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    主要参考文献

    [参考文献]: Danqing Min, Et Al. 2-Methoxy-2,4-Diphenyl-3(2H)-Furanone-Labeled Gelatin Zymography And Reverse Zymography: A Rapid Real-Time Method For Quantification Of Matrix Metalloproteinases-2 And -9 And Tissue Inhibitors Of Metalloproteinases. Electrophoresis. 20
    [参考文献]: Peter Jackson. Detection Of Phosphoproteins. Wo2006070180.
    [参考文献]: Ali Nawaz, Et Al. Proteolytic Activity And Cytokine Up-Regulation By Non-Albicans Candida Albicans. Arch Microbiol. 2015 May;197(4):533-7.
    [参考文献]: J C Stockert, Et Al. Fluorescence Of Eosinophil Leukocyte Granules Induced By The Fluorogenic Reagent 2-Methoxy-2,4-Diphenyl-3 (2H)-Furanone. Blood Cells. 1993;19(2):423-30; Discussion 431-3.
    [参考文献]: J R Daban, Et Al. Fluorescent Labeling Of Proteins With Nile Red And 2-Methoxy-2,4-Diphenyl-3(2H)-Furanone: Physicochemical Basis And Application To The Rapid Staining Of Sodium Dodecyl Sulfate Polyacrylamide Gels And Western Blots. Electrophoresis. 2001 Mar;22(5):874-80.

    合成参考文献


    参考文献:10.1007/bf01119628
    摘要:Stevenson GA, Lyons JG, Cameron DA, O'Grady RL. Rat carcinoma cells in long-term, serum-free culture provide a continuing supply of collagenase. Biosci Rep. 1985 Dec;5(12):1071–7. doi: 10.1007/bf01119628.
    参考文献:10.1023/b:clin.0000006819.21361.03
    摘要:Mathisen B, Lindstad RI, Hansen J, El-Gewely SA, Maelandsmo GM, Hovig E, Fodstad Ø, Loennechen T, Winberg J. S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells. Clinical & Experimental Metastasis. 2003 Dec;20(8):701–11. doi: 10.1023/b:clin.0000006819.21361.03.
    参考文献:10.1002/elps.200406003
    摘要:Castro-Hartmann P, Daban JR. Flow and evaporation cells for the detection of proteins on membranes with the peroxyoxalate chemiluminescent reaction in organic media. Electrophoresis. 2004 Aug;25(15):2501–5. doi: 10.1002/elps.200406003.
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