CAS: 42454-06-8; 5-Hydroxy-2-Nitrobenzaldehyde

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CAS号100-83-4 间羟基苯甲醛 | CAS号454466-61-6 3-formyl-4-nitr... | CAS号454466-57-0 3-formylphenyl ... | CAS号59342-81-3 ethyl (3-formyl... | CAS号68423-35-8 3-ethoxycarbony... | CAS号7697-37-2 硝酸 | CAS号105728-11-8 N-cyclohexyl-5-... | CAS号105728-02-7 (3-甲酰基-4-硝基苯氧基)乙酸乙酯 | CAS号38469-84-0 2-硝基-5-甲氧基苯腈 | CAS号26831-52-7 Benzaldehyde,2-... | CAS号850424-11-2 2-氯-6-甲氧基喹唑啉 | CAS号1882-69-5 5-甲氧基-2-硝基苯甲酸 | CAS号610-37-7 5-羟基-2-硝基苯甲酸 | CAS号54197-64-7 6-甲氧基-3,4-二氢-2(... | CAS号1027818-09-2 Carbonic acid t... | CAS号60463-12-9 5-羟基-2-硝基苯甲醇

Ethyl (3-Formylphenyl) Carbonate置于硫酸,硝酸,Sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应 6.5H,反应生成 5-羟基-2-硝基苯甲醛
参考文献:轻触发的硫代马来酰亚胺环水解稳定快速地合成巯基
标题:轻触发的硫代马来酰亚胺环水解稳定快速地合成巯基
摘要:马来酰亚胺介导的生物分子巯基特异性衍生化是目前可用的最有效的生物缀合方法之一.然而,令人震惊的是,最近的研究表明,所得的硫代马来酰亚胺共轭物易于通过硫醇交换反应分解.在此,我们报道了一种新的马来酰亚胺,即o-Ch 2 Nh Ipr苯基马来酰亚胺,在巯基结合后会经历前所未有的快速环水解,形成稳定的耐巯基交换抗性的偶联物.此外,我们通过开发抗环水解的光笼型支架,克服了由于马来酰亚胺试剂在生物缀合之前易于发生环水解的问题,从而克服了马来酰亚胺试剂保质期低的问题.用这种光笼封的马来酰亚胺形成的硫醇生物共轭物的紫外线照射可在温和,冰冷的条件下1小时内迅速释放出硫代马来酰亚胺环,从而产生所需的稳定共轭物.
DOI:10.1002/anie.201609733

专利信息

专利号:US-5679864-A
优先权日:1995-11-03
标题:Process for the synthesis of curcumin-related compounds
发明人：KRACKOV MARK HARRY; BELLIS HAROLD EDWARD
权利人:GENE PRINT INC
摘要:The invention is directed to a process for the synthesis of curcumin and curcumin-related compounds by reacting the enol form of a 2,4-diketone with a monocarbocyclic aldehyde in the presence of an organic amine catalyst. The reactants are dissolved in a highly polar, aprotic organic solvent. The curcumin-related product is recovered in crystalline form by precipitation from the reaction mass and solvent recrystallization.

专利号:US-7608740-B2
优先权日:2005-08-03
标 题 :Method of synthesizing key intermediates for the production of camptothecin derivatives
发明人：RAO RAMAKRISHNA; RAO ALLA VENKATA RAMA
权利人:AVRA LAB PVT LTD
摘要:The present invention discloses a process for efficient production of 2-amino-5-hydroxypropiophenone corresponding to the AB ring part of camptothecin (CPT) skeleton, which is a key intermediate useful for the total synthesis of camptothecin analogs including 7-Ethyl-10-hydroxy camptothecin and novel intermediates thereof.

专利号:US-11434196-B2
优先权日:2019-01-15
标 题 :Process for preparation of 2-Amino-5-hydroxy propiophenone
发明人：VASIREDDI UMA MAHESWER RAO; KINTALI VENKATA RAMANA; DADI JAGADEESWARA RAO; KATKURI RAJ KOTI; TUMMU SRIDHAR
权利人:LAURUS LABS LTD
摘要:The present invention relates to a process for preparation of 2-Amino-5-hydroxy propiophenone, a key intermediate for the synthesis of camptothecin analogs including 7-Ethyl-10-hydroxycamptothecin (SN-38).

专利号:US-11173212-B2
优先权日:2017-09-28
标 题 :Supramolecular protein assemblies with advanced functions and synthesis thereof
发明人：BRITTO Sandanaraj Selvaraj; BHANDARI PAVANKUMAR JANARDHAN; REDDY Mullapudi Mohan
权利人:INDIAN INSTITUTE OF SCIENCE EDUCATION AND RES
摘要:The present invention discloses stimuli-sensitive protein conjugate which can make supramolecular protein assemblies and methods for using the same. The present invention provides simple and rational process for construction of said stimuli-sensitive spherical protein assemblies through supramolecular chemical strategy.

专利号:US-6642417-B2
优先权日:1998-07-23
标题:Photocleavable and acid cleavable linkers for combinatorial chemistry
发明人：TRAN VINH D; MA VU VAN; LIU RUIYAN
权利人:PHARMACOPEIA DRUG DISCOVERY
摘要:A substrate for solid phase synthesis comprising a solid phase-linker combination of the formula I is disclosed. Also disclosed are processes for preparing the substrate and chemical intermediates useful therein. Among the novel intermediates are compounds of the formula II wherein R<1 >is -NO2 or -CHO; R<2 >is -OCH3, -CHO or -H; R<3 >is chosen from the group consisting of hydroxyl, the residue of a solid support having a plurality of amino groups, and the residue of an ester, and n=1 or 3-12.A substrate of solid phase synthesis of the formula III is also disclosed.

专利号:US-7378555-B2
优先权日:2001-02-21
标 题 :Method of synthesizing camptothecin-relating compounds
发明人：OGAWA TAKANORI; NISHIYAMA HIROYUKI; UCHIDA MIYUKI; SAWADA SEIGO
权利人:YAKULT HONSHA KK
摘要:The present invention is to prepare efficiently 2′-amino-5′-hydroxypropiophenone corresponding to the AB-ring part of camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE-ring part in order to provide efficiently CPT by the total synthesis, which is a starting material for irinotecan hydrochloride and various kinds of camptothecin derivatives, and to provide stably CPT and its derivatives.